%0 Journal Article
%A Glynne, Sarah
%T Estrogen-Only Hormone Therapy and Dementia
%B JAMA
%D 2024
%R 10.1001/jama.2024.4071
%J JAMA
%V 331
%N 18
%P 1594-1594
%@ 0098-7484
%X To the Editor A recent study reported an increased dementia risk in women using estrogen-only menopausal hormone therapy, which mirrors findings of an earlier study by these authors that demonstrated an increased dementia risk associated with combined menopausal hormone therapy. These studies have many similar limitations, including confounding by indication, multiple sources of bias, and failure to adjust for factors known to influence dementia risk. In a similar study that adjusted for multiple confounding factors, estrogen-only hormone therapy was associated with a 1.1% decrease in dementia risk per year when used for more than 10 years (hazard ratio, 0.85; 95% CI, 0.76-0.94; P = .003).
%[ 5/20/2024
%U https://doi.org/10.1001/jama.2024.4071