RT Journal Article
A1 Glynne, Sarah
T1 Estrogen-Only Hormone Therapy and Dementia
JF JAMA
JO JAMA
YR 2024
DO 10.1001/jama.2024.4071
VO 331
IS 18
SP 1594
OP 1594
SN 0098-7484
AB To the Editor A recent study reported an increased dementia risk in women using estrogen-only menopausal hormone therapy, which mirrors findings of an earlier study by these authors that demonstrated an increased dementia risk associated with combined menopausal hormone therapy. These studies have many similar limitations, including confounding by indication, multiple sources of bias, and failure to adjust for factors known to influence dementia risk. In a similar study that adjusted for multiple confounding factors, estrogen-only hormone therapy was associated with a 1.1% decrease in dementia risk per year when used for more than 10 years (hazard ratio, 0.85; 95% CI, 0.76-0.94; P = .003).
RD 5/20/2024
UL https://doi.org/10.1001/jama.2024.4071