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  • Serious Bleeding in Patients With Atrial Fibrillation Using Diltiazem With Apixaban or Rivaroxaban

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    JAMA. 2024; 331(18):1565-1575. 10.1001/jama.2024.3867

    This cohort study assesses the association of diltiazem with risk of serious bleeding compared with metoprolol in older adults with atrial fibrillation receiving apixaban or rivaroxaban.

  • Mendelian Randomization Analysis of Genetic Proxies of Thiazide Diuretics and the Reduction of Kidney Stone Risk

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    ÁñÁ«ÊÓƵ Netw Open. 2023; 6(11):e2343290. 10.1001/jamanetworkopen.2023.43290

    This genetic association study including genome-wide association study summary statistics of US and European adults uses mendelian randomization analysis to examine the association of genetic proxies of thiazide diuretics with the risk of kidney stones.

  • Association of Kidney Comorbidities and Acute Kidney Failure With Unfavorable Outcomes After COVID-19 in Individuals With the Sickle Cell Trait

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    JAMA Intern Med. 2022; 182(8):796-804. 10.1001/jamainternmed.2022.2141

    This genetic association study assesses the association of sickle cell trait with prepandemic health conditions in Million Veteran Program participants and assesses the severity and sequelae of COVID-19.

  • APOL1 Risk Variants, Acute Kidney Injury, and Death in Participants With African Ancestry Hospitalized With COVID-19 From the Million Veteran Program

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    JAMA Intern Med. 2022; 182(4):386-395. 10.1001/jamainternmed.2021.8538

    This cohort study of US veterans hospitalized with COVID-19 with genetic information and with African ancestry through the VA Million Veteran Program to evaluates the association of APOL1 variations with.acute kidney injury

  • Association of Rivaroxaban vs Apixaban With Major Ischemic or Hemorrhagic Events in Patients With Atrial Fibrillation

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    JAMA. 2021; 326(23):2395-2404. 10.1001/jama.2021.21222

    This cohort study assesses major ischemic and hemorrhagic outcomes in Medicare beneficiaries with atrial fibrillation who were treated with rivaroxaban compared with apixaban.

  • Association of Treatment With Metformin vs Sulfonylurea With Major Adverse Cardiovascular Events Among Patients With Diabetes and Reduced Kidney Function

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    JAMA. 2019; 322(12):1167-1177. 10.1001/jama.2019.13206

    This cohort study uses data from the National Veterans Health Administration, Medicare, Medicaid, and National Death Index to compare major adverse cardiovascular events among patients with diabetes and reduced kidney function who continued treatment with metformin or sulfonylurea.

  • Association Between Intensification of Metformin Treatment With Insulin vs Sulfonylureas and Cardiovascular Events and All-Cause Mortality Among Patients With Diabetes

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    JAMA. 2014; 311(22):2288-2296. 10.1001/jama.2014.4312

    In a retrospective cohort study of veterans with diabetes initially treated with metformin, Roumie and coauthors compared time to acute myocardial infarction, stroke, or death in patients who added insulin or a sulfonylurea.