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JAMA Psychiatry
Review
April 3, 2024
MartenScheffer,PhD; Claudi L.Bockting,PhD; DennyBorsboom,PhD; RoshanCools,PhD; ClaraDelecroix,MSc; Jessica A.Hartmann,PhD; Kenneth S.Kendler,MD; Ingridvan de Leemput,PhD; Han L. J.van der Maas,PhD; Egbertvan Nes,PhD; MarkMattson,PhD; Pat D.McGorry,PhD; BarnabyNelson,PhD
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online first
JAMA Psychiatry. 2024; 10.1001/jamapsychiatry.2024.0228
This narrative review, the second of 2 parts about a new approach to the diagnosis and treatment of psychiatric disorders that is based on dynamical systems theory, describes the implications of evidence for the practical applicability of this theory and its quantitative tools.
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JAMA Psychiatry
Review
April 3, 2024
MartenScheffer,PhD; Claudi L.Bockting,PhD; DennyBorsboom,PhD; RoshanCools,PhD; ClaraDelecroix,MSc; Jessica A.Hartmann,PhD; Kenneth S.Kendler,MD; Ingridvan de Leemput,PhD; Han L. J.van der Maas,PhD; Egbertvan Nes,PhD; MarkMattson,PhD; Pat D.McGorry,PhD; BarnabyNelson,PhD
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online first
JAMA Psychiatry. 2024; 10.1001/jamapsychiatry.2024.0215
This narrative review describes a new approach to the diagnosis and treatment of psychiatric disorders that is based on dynamical systems theory, which addresses the concepts of tipping points, cycles, and chaos in complex systems.
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JAMA Psychiatry
Original Investigation
September 20, 2023
SidhantChopra,PhD; AshleaSegal,PhD; StuartOldham,PhD; AlexanderHolmes,BSc; KristinaSabaroedin,PhD; Edwina R.Orchard,PhD; Shona M.Francey,PhD; BrianO’Donoghue,MD, PhD; VanessaCropley,PhD; BarnabyNelson,PhD; JessicaGraham,MClinPsych; LaraBaldwin,BSc; JegganTiego,PhD; Hok PanYuen,PhD; KellyAllott,DPsych; MarioAlvarez-Jimenez,PhD; SusyHarrigan,PhD; Ben D.Fulcher,PhD; KevinAquino,PhD; ChristosPantelis,MD, PhD; Stephen J.Wood,PhD; MarkBellgrove,PhD; Patrick D.McGorry,MD, PhD; AlexFornito,PhD
JAMA Psychiatry. 2023; 80(12):1246-1257. 10.1001/jamapsychiatry.2023.3293
This case-control study models the processes that explain spatial patterns of gray matter volume loss in different stages of psychotic illness and assesses whether certain brain regions act as putative epicenters from which volume loss spreads.
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Ƶ Network Open
Original Investigation
Psychiatry
September 15, 2023
AswinRatheesh,MD, PhD; DylanHammond,MPsych; MichaelWatson,MBBS; JenniferBetts,DPsych; EmmaSiegel,MPH; PatrickMcGorry,MD, PhD; MichaelBerk,MBBCh, PhD; SusanCotton,PhD; AndrewChanen,MBBS, PhD; BarnabyNelson,PhD; AndreasBechdolf,MSc
open access
Ƶ Netw Open. 2023; 6(9):e2334078. 10.1001/jamanetworkopen.2023.34078
This cohort study assesses whether patients meeting bipolar at-risk criteria have greater risk of developing bipolar disorder at 10 to 13 years of follow-up than patients not meeting the criteria.
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JAMA Psychiatry
Original Investigation
June 28, 2023
Patrick D.McGorry,MD, PhD; CristinaMei,PhD; G. PaulAmminger,MD, PhD, (Habil); Hok PanYuen,PhD; MelissaKerr,LLM; JessicaSpark,BPsych; NickyWallis,PhD; AndreaPolari,MD; ShelleyBaird,BPsych, BN; KateBuccilli,BPsych, MPPM; Sarah-Jane A.Dempsey,PhD; NatalieFerguson,MClinPsych; MelanieFormica,BA, (Psych), (Hons); MarijaKrcmar,BSci, (Hons); Amelia L.Quinn,BPsych, (Hons); YohannesMebrahtu,MLA; ArlanRuslins,BPsychSc, (Hons); RebekahStreet,LLB; CassandraWannan,PhD; LisaDixon,MD, MPH; CameronCarter,MD; RachelLoewy,PhD; Tara A.Niendam,PhD; MarthaShumway,PhD; BarnabyNelson,PhD
open access
has multimedia
JAMA Psychiatry. 2023; 80(9):875-885. 10.1001/jamapsychiatry.2023.1947
This sequential multiple assignment randomized trial evaluates the efficacy of an intervention strategy for individuals at ultrahigh risk of psychosis.
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JAMA Psychiatry
Original Investigation
June 23, 2021
SidhantChopra,BSc; Shona M.Francey,PhD; BrianO’Donoghue,MD, PhD; KristinaSabaroedin,BSc; AurinaArnatkeviciute,PhD; VanessaCropley,PhD; BarnabyNelson,PhD; JessicaGraham,MClinPsych; LaraBaldwin,BSc; StevenTahtalian,BSc; Hok PanYuen,PhD; KellyAllott,DPsych; MarioAlvarez-Jimenez,PhD; SusyHarrigan,PhD; ChristosPantelis,MD, PhD; Stephen J.Wood,PhD; PatrickMcGorry,MD, PhD; AlexFornito,PhD
open access
JAMA Psychiatry. 2021; 78(9):994-1004. 10.1001/jamapsychiatry.2021.1422
This secondary analysis of a randomized clinical trial investigates differential patterns of brain connectivity in antipsychotic-treated and antipsychotic-naive patients with psychosis and how these patterns change over time.
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JAMA Psychiatry
Original Investigation
August 26, 2020
DavidMongan,MB BCh, BAO; MelanieFöcking,PhD; ColmHealy,MSc; Subash RajSusai,MSc; MeikeHeurich,PhD; KieranWynne,MSc; BarnabyNelson,PhD; Patrick D.McGorry,PhD; G. PaulAmminger,PhD; MereteNordentoft,PhD; Marie-OdileKrebs,PhD; AnitaRiecher-Rössler,PhD; Rodrigo A.Bressan,PhD; NeusBarrantes-Vidal,PhD; StefanBorgwardt,MD; StephanRuhrmann,MD; GabrieleSachs,PhD; ChristosPantelis,MD; Markvan der Gaag,PhD; Lieuwede Haan,PhD; LuciaValmaggia,PhD; Thomas A.Pollak,PhD; Matthew J.Kempton,PhD; Bart P. F.Rutten,PhD; RobertWhelan,PhD; MaryCannon,PhD; StanZammit,PhD; GerardCagney,PhD; David R.Cotter,PhD; PhilipMcGuire,PhD; European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) High Risk Study Group
open access
JAMA Psychiatry. 2020; 78(1):77-90. 10.1001/jamapsychiatry.2020.2459
This diagnostic study investigates whether proteomic biomarkers may aid the prediction of transition to psychotic disorder in the clinical high-risk state and adolescent psychotic experiences in the general population.
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JAMA Psychiatry
Editorial
March 11, 2020
Patrick D.McGorry,MD, PhD; BarnabyNelson,PhD
JAMA Psychiatry. 2020; 77(7):559-560. 10.1001/jamapsychiatry.2019.4635
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JAMA Psychiatry
Original Investigation
November 13, 2019
GemmaModinos,PhD; Matthew J.Kempton,PhD; StefaniaTognin,PhD; MariaCalem,PhD; LillaPorffy,MSc; MathildeAntoniades,PhD; AvaMason,MSc; MatildaAzis,PhD; PaulAllen,PhD; BarnabyNelson,PhD; PatrickMcGorry,MD, PhD; ChristosPantelis,MD; AnitaRiecher-Rössler,MD; StefanBorgwardt,MD; RodrigoBressan,MD, PhD; NeusBarrantes-Vidal,PhD; Marie-OdileKrebs,MD, PhD; MereteNordentoft,MD, PhD; BirteGlenthøj,MD, DMSc; StephanRuhrmann,MD; GabrieleSachs,MD; BartRutten,MD, PhD; Jimvan Os,MD, PhD; Lieuwede Haan,MD, PhD; EvaVelthorst,PhD; Markvan der Gaag,PhD; Lucia R.Valmaggia,PhD; PhilipMcGuire,MD, PhD; for the EU-GEI High Risk Study Group
open access
JAMA Psychiatry. 2019; 77(2):190-200. 10.1001/jamapsychiatry.2019.3501
This case-control study analyzes emotion recognition and neuroimaging data as well as clinical and functional outcomes for individuals at risk for transition to psychosis and those without psychiatric or neurological disorders.
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JAMA Psychiatry
Comment & Response
February 6, 2019
BarnabyNelson,PhD; Alison R.Yung,MD, FRANZCP; Patrick D.McGorry,MD, PhD, FRCP, FRANZCP
JAMA Psychiatry. 2019; 76(3):339-339. 10.1001/jamapsychiatry.2018.4234
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JAMA Psychiatry
Comment & Response
June 1, 2017
Patrick D.McGorry,MD, PhD; BarnabyNelson,PhD; PaulAmminger,MD, PhD(Habil)
JAMA Psychiatry. 2017; 74(6):652-653. 10.1001/jamapsychiatry.2017.0184
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JAMA Psychiatry
Review
May 1, 2017
BarnabyNelson,PhD; Patrick D.McGorry,MD, PhD; MariekeWichers,PhD; Johanna T. W.Wigman,PhD; Jessica A.Hartmann,PhD
JAMA Psychiatry. 2017; 74(5):528-534. 10.1001/jamapsychiatry.2017.0001
This review presents several cross-disciplinary models of system change (dynamical systems theory, network theory, instability mechanisms, chaos theory, and catastrophe theory) and suggests how they may be conceptually and empirically applied to psychopathological prediction research.
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JAMA Psychiatry
Original Investigation
January 1, 2017
Patrick D.McGorry,MD, PhD; BarnabyNelson,PhD; ConnieMarkulev,M Psych Clin; Hok PanYuen,MSc; Miriam R.Schäfer,MD; NilufarMossaheb,MD; MonikaSchlögelhofer,Mag; StephanSmesny,MD, PhD; Ian B.Hickie,MD; Gregor EmanuelBerger,MD; Eric Y. H.Chen,MD; Lieuwede Haan,MD, PhD; Dorien H.Nieman,PhD; MereteNordentoft,MD, PhD; AnitaRiecher-Rössler,MD, PhD; SwapnaVerma,MBBS; AndrewThompson,MD, MBBS; Alison RuthYung,MD, FRANZCP; G. PaulAmminger,MD, PhD (Habil)
free access
JAMA Psychiatry. 2017; 74(1):19-27. 10.1001/jamapsychiatry.2016.2902
This randomized clinical trial assesses the effect of ω-3 polyunsaturated fatty acids vs placebo on the transition to psychosis in persons at ultrahigh risk for psychotic disorders.
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JAMA Psychiatry
Editorial
March 1, 2016
PatrickMcGorry,MD, PhD, FRCP, FRANZCP; BarnabyNelson,PhD
JAMA Psychiatry. 2016; 73(3):191-192. 10.1001/jamapsychiatry.2015.2868
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JAMA Psychiatry
Original Investigation
Meta-analysis
February 1, 2016
PaoloFusar-Poli,MD, PhD; MarcoCappucciati,MD; StefanBorgwardt,MD, PhD; Scott W.Woods,MD; JeanAddington,PhD; BarnabyNelson,PhD; Dorien H.Nieman,PhD; Daniel R.Stahl,PhD; GraziaRutigliano,MD; AnitaRiecher-Rössler,MD, PhD; Andor E.Simon,MD; MasafumiMizuno,MD, PhD; Tae YoungLee,MD; Jun SooKwon,MD, PhD; May M. L.Lam,MBBS; JesusPerez,PhD; SzabolcsKeri,MD, PhD; PaulAmminger,MD, PhD, FRANZCP; SibylleMetzler,PhD; WolframKawohl,MD; WulfRössler,MSc, MD; JimmyLee,MBBS, MMed(Psychiatry), MCI; JavierLabad,MD, PhD; TimZiermans,PhD; Suk KyoonAn,MD, PhD; Chen-ChungLiu,MD, PhD; Kristen A.Woodberry,MSW, PhD; AmelBraham,MD; CherylCorcoran,MD; PatrickMcGorry,MD, PhD, FRCP, FRANZCP; Alison R.Yung,MD; Philip K.McGuire,MD, PhD
free access
JAMA Psychiatry. 2016; 73(2):113-120. 10.1001/jamapsychiatry.2015.2324
This meta-analysis compares the risk of psychosis among clinical high-risk individuals with at least 1 of the major inclusion criteria for psychosis.
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JAMA Psychiatry
Original Investigation
August 1, 2013
Barnaby Nelson, PhD; Hok Pan Yuen, MSc; Stephen J. Wood, PhD; Ashleigh Lin, PhD; Daniela Spiliotacopoulos, MSc; Annie Bruxner, BA; Christina Broussard, BA; Magenta Simmons, PhD; Debra L. Foley, PhD; Warrick J. Brewer, PhD; Shona M. Francey, PhD; G. Paul Amminger, MD; Andrew Thompson, MD; Patrick D. McGorry, PhD; Alison R. Yung, MD
free access
JAMA Psychiatry. 2013; 70(8):793-802. 10.1001/jamapsychiatry.2013.1270
Nelson et al assess the rate and baseline predictors of transition in 416 patients at ultra high risk for development of schizophrenia and other psychotic disorders up to 15 years after study entry.