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  • A Dynamical Systems View of Psychiatric Disorders—Practical Implications: A Review

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    JAMA Psychiatry. 2024; 10.1001/jamapsychiatry.2024.0228

    This narrative review, the second of 2 parts about a new approach to the diagnosis and treatment of psychiatric disorders that is based on dynamical systems theory, describes the implications of evidence for the practical applicability of this theory and its quantitative tools.

  • A Dynamical Systems View of Psychiatric Disorders—Theory: A Review

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    JAMA Psychiatry. 2024; 10.1001/jamapsychiatry.2024.0215

    This narrative review describes a new approach to the diagnosis and treatment of psychiatric disorders that is based on dynamical systems theory, which addresses the concepts of tipping points, cycles, and chaos in complex systems.

  • Network-Based Spreading of Gray Matter Changes Across Different Stages of Psychosis

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    JAMA Psychiatry. 2023; 80(12):1246-1257. 10.1001/jamapsychiatry.2023.3293

    This case-control study models the processes that explain spatial patterns of gray matter volume loss in different stages of psychotic illness and assesses whether certain brain regions act as putative epicenters from which volume loss spreads.

  • Bipolar At-Risk Criteria and Risk of Bipolar Disorder Over 10 or More Years

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    Ƶ Netw Open. 2023; 6(9):e2334078. 10.1001/jamanetworkopen.2023.34078

    This cohort study assesses whether patients meeting bipolar at-risk criteria have greater risk of developing bipolar disorder at 10 to 13 years of follow-up than patients not meeting the criteria.

  • A Sequential Adaptive Intervention Strategy Targeting Remission and Functional Recovery in Young People at Ultrahigh Risk of Psychosis: The Staged Treatment in Early Psychosis (STEP) Sequential Multiple Assignment Randomized Trial

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    JAMA Psychiatry. 2023; 80(9):875-885. 10.1001/jamapsychiatry.2023.1947

    This sequential multiple assignment randomized trial evaluates the efficacy of an intervention strategy for individuals at ultrahigh risk of psychosis.

  • Functional Connectivity in Antipsychotic-Treated and Antipsychotic-Naive Patients With First-Episode Psychosis and Low Risk of Self-harm or Aggression: A Secondary Analysis of a Randomized Clinical Trial

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    JAMA Psychiatry. 2021; 78(9):994-1004. 10.1001/jamapsychiatry.2021.1422

    This secondary analysis of a randomized clinical trial investigates differential patterns of brain connectivity in antipsychotic-treated and antipsychotic-naive patients with psychosis and how these patterns change over time.

  • Development of Proteomic Prediction Models for Transition to Psychotic Disorder in the Clinical High-Risk State and Psychotic Experiences in Adolescence

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    JAMA Psychiatry. 2020; 78(1):77-90. 10.1001/jamapsychiatry.2020.2459

    This diagnostic study investigates whether proteomic biomarkers may aid the prediction of transition to psychotic disorder in the clinical high-risk state and adolescent psychotic experiences in the general population.

  • Clinical High Risk for Psychosis—Not Seeing the Trees for the Wood

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    JAMA Psychiatry. 2020; 77(7):559-560. 10.1001/jamapsychiatry.2019.4635
  • Association of Adverse Outcomes With Emotion Processing and Its Neural Substrate in Individuals at Clinical High Risk for Psychosis

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    JAMA Psychiatry. 2019; 77(2):190-200. 10.1001/jamapsychiatry.2019.3501

    This case-control study analyzes emotion recognition and neuroimaging data as well as clinical and functional outcomes for individuals at risk for transition to psychosis and those without psychiatric or neurological disorders.

  • Importance of Variable Selection in Multimodal Prediction Models in Patients at Clinical High Risk for Psychosis and Recent-Onset Depression

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    JAMA Psychiatry. 2019; 76(3):339-339. 10.1001/jamapsychiatry.2018.4234
  • Negative Psychosis Prevention Trials—Reply

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    JAMA Psychiatry. 2017; 74(6):652-653. 10.1001/jamapsychiatry.2017.0184
  • Moving From Static to Dynamic Models of the Onset of Mental Disorder: A Review

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    JAMA Psychiatry. 2017; 74(5):528-534. 10.1001/jamapsychiatry.2017.0001

    This review presents several cross-disciplinary models of system change (dynamical systems theory, network theory, instability mechanisms, chaos theory, and catastrophe theory) and suggests how they may be conceptually and empirically applied to psychopathological prediction research.

  • Effect of ω-3 Polyunsaturated Fatty Acids in Young People at Ultrahigh Risk for Psychotic Disorders: The NEURAPRO Randomized Clinical Trial

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    JAMA Psychiatry. 2017; 74(1):19-27. 10.1001/jamapsychiatry.2016.2902

    This randomized clinical trial assesses the effect of ω-3 polyunsaturated fatty acids vs placebo on the transition to psychosis in persons at ultrahigh risk for psychotic disorders.

  • Why We Need a Transdiagnostic Staging Approach to Emerging Psychopathology, Early Diagnosis, and Treatment

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    JAMA Psychiatry. 2016; 73(3):191-192. 10.1001/jamapsychiatry.2015.2868
  • Heterogeneity of Psychosis Risk Within Individuals at Clinical High Risk: A Meta-analytical Stratification

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    JAMA Psychiatry. 2016; 73(2):113-120. 10.1001/jamapsychiatry.2015.2324

    This meta-analysis compares the risk of psychosis among clinical high-risk individuals with at least 1 of the major inclusion criteria for psychosis.

  • Long-term Follow-up of a Group at Ultra High Risk (“Prodromal”) for Psychosis: The PACE 400 Study

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    JAMA Psychiatry. 2013; 70(8):793-802. 10.1001/jamapsychiatry.2013.1270

    Nelson et al assess the rate and baseline predictors of transition in 416 patients at ultra high risk for development of schizophrenia and other psychotic disorders up to 15 years after study entry.