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This cohort study assesses the association of diltiazem with risk of serious bleeding compared with metoprolol in older adults with atrial fibrillation receiving apixaban or rivaroxaban.

This cohort study uses patient data from the Medicaid and Children’s Health Insurance Program to investigate if antipsychotic treatment of children and young adults without severe somatic illness or psychosis is associated with increased risk of death.

This cohort study assesses major ischemic and hemorrhagic outcomes in Medicare beneficiaries with atrial fibrillation who were treated with rivaroxaban compared with apixaban.

This cohort study uses a mendelian randomization approach with variants in the HMGCR gene to evaluate associations between statin therapy and noncardiovascular diseases.

This genetic association study examines whether the rs2814778-CC genotype is associated with an increased likelihood of receiving a bone marrow biopsy for an isolated low white blood cell count.

This cohort study tests the associations between PCSK9 genetic variants, a PCSK9 genetic risk score, or genetically estimated PCSK9 expression levels and the risk of sepsis among patients admitted to a hospital with infection.

This cohort study of medical records assesses whether low-density lipoprotein cholesterol (LDL-C) levels are associated with an increased risk of sepsis among patients admitted to the hospital with infection.

This cohort study of Tennessee Medicaid enrollees from 1999 through 2014 investigates the risk of unexpected death among children and youths aged 5 through 24 years without psychosis who are new users of antipsychotic medications compared with new users of control medications.

This pharmacoepidemiology study examines the association between oral anticoagulants (warfarin, apixaban, dabigatran, and rivaroxaban), cotherapy with proton pump inhibitors (PPIs), and upper gastrointestinal (UGI) tract bleeding in Medicare beneficiaries.

This retrospective study compared risk of death among Medicaid patients in Tennessee initiating long-acting opioid therapy for chronic noncancer pain with patients taking anticonvulsants or cyclic antidepressants.

This retrospective cohort study determines that the increased risk of death associated with methadone use outside the hospital supports recommendations that it should not be a drug of first choice for treatment of noncancer pain.

In a retrospective cohort study, Bobo and coauthors compare the risk of type 2 diabetes in children and youth 6 to 24 years of age for recent initiators of antipsychotic drugs vs propensity score–matched controls who had recently another psychotropic medication.