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  • Serious Bleeding in Patients With Atrial Fibrillation Using Diltiazem With Apixaban or Rivaroxaban

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    JAMA. 2024; 331(18):1565-1575. 10.1001/jama.2024.3867

    This cohort study assesses the association of diltiazem with risk of serious bleeding compared with metoprolol in older adults with atrial fibrillation receiving apixaban or rivaroxaban.

  • APOL1 Risk Variants, Acute Kidney Injury, and Death in Participants With African Ancestry Hospitalized With COVID-19 From the Million Veteran Program

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    JAMA Intern Med. 2022; 182(4):386-395. 10.1001/jamainternmed.2021.8538

    This cohort study of US veterans hospitalized with COVID-19 with genetic information and with African ancestry through the VA Million Veteran Program to evaluates the association of APOL1 variations with.acute kidney injury

  • Association of Rivaroxaban vs Apixaban With Major Ischemic or Hemorrhagic Events in Patients With Atrial Fibrillation

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    JAMA. 2021; 326(23):2395-2404. 10.1001/jama.2021.21222

    This cohort study assesses major ischemic and hemorrhagic outcomes in Medicare beneficiaries with atrial fibrillation who were treated with rivaroxaban compared with apixaban.

  • A Genetic Approach to the Association Between PCSK9 and Sepsis

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    ÁñÁ«ÊÓƵ Netw Open. 2019; 2(9):e1911130. 10.1001/jamanetworkopen.2019.11130

    This cohort study tests the associations between PCSK9 genetic variants, a PCSK9 genetic risk score, or genetically estimated PCSK9 expression levels and the risk of sepsis among patients admitted to a hospital with infection.

  • Association Between Low-Density Lipoprotein Cholesterol Levels and Risk for Sepsis Among Patients Admitted to the Hospital With Infection

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    ÁñÁ«ÊÓƵ Netw Open. 2019; 2(1):e187223. 10.1001/jamanetworkopen.2018.7223

    This cohort study of medical records assesses whether low-density lipoprotein cholesterol (LDL-C) levels are associated with an increased risk of sepsis among patients admitted to the hospital with infection.

  • Association of Oral Anticoagulants and Proton Pump Inhibitor Cotherapy With Hospitalization for Upper Gastrointestinal Tract Bleeding

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    JAMA. 2018; 320(21):2221-2230. 10.1001/jama.2018.17242

    This pharmacoepidemiology study examines the association between oral anticoagulants (warfarin, apixaban, dabigatran, and rivaroxaban), cotherapy with proton pump inhibitors (PPIs), and upper gastrointestinal (UGI) tract bleeding in Medicare beneficiaries.

  • Prescription of Long-Acting Opioids and Mortality in Patients With Chronic Noncancer Pain

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    JAMA. 2016; 315(22):2415-2423. 10.1001/jama.2016.7789

    This retrospective study compared risk of death among Medicaid patients in Tennessee initiating long-acting opioid therapy for chronic noncancer pain with patients taking anticonvulsants or cyclic antidepressants.

  • Out-of-Hospital Mortality Among Patients Receiving Methadone for Noncancer Pain

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    JAMA Intern Med. 2015; 175(3):420-427. 10.1001/jamainternmed.2014.6294

    This retrospective cohort study determines that the increased risk of death associated with methadone use outside the hospital supports recommendations that it should not be a drug of first choice for treatment of noncancer pain.