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This cohort study characterizes heterogeneity in cardiac function prior to sepsis and describes associations with hospitalization outcomes and mortality.

This article summarizes the 2023 updated ARDS guidelines from the European Society of Intensive Care Medicine, including the guidelines鈥� methods, findings, and implications, along with reflections on next steps.

This cohort study evaluates the association between preexisting heart failure with reduced ejection fraction, guideline-recommended intravenous fluid resuscitation, and mortality among patients with community-acquired sepsis and septic shock.

This combined cohort study and randomized comparative effectiveness trial examines the hospitalization and mortality outcomes among outpatients receiving monoclonal antibodies to treat COVID-19 caused by the SARS-CoV-2 Delta variant.

This cohort study evaluates data from a 14-hospital integrated health care system to determine the association between time to source control and patient outcomes in community-acquired sepsis.

This cohort study evaluates the clinical outcomes of patients with COVID-19 receiving subcutaneous vs intravenous treatment with casirivimab and imdevimab.

This Viewpoint discusses the trend toward identifying 鈥渟ubtypes鈥� of various diseases (eg, asthma and COPD) and proposes criteria for justifying subclassifications of COVID-19, including biological plausibility, prompt identifiability, nonoverlap in cases, reproducibility, and treatment responsiveness

This cohort study examines a virtually enabled biorepository and electronic health record (EHR)鈥揺mbedded tool for use in precision medicine in patients with sepsis.

This Viewpoint discusses the tensions between rapid adoption of interventions for coronavirus disease 2019 (COVID-19) before adequate evidence justifies their use and therapeutic nihilism, and argues for sensible medicine between the 2, which favors usual care, disfavors unnecessary interventions, but embraces rapid scientific evaluation with clinical translation of options proven effective.

This cohort study describes the mortality and readmission outcomes of prescribing metformin beyond its use to control blood glucose levels in adults with type 2 diabetes.

In this study, Sepsis-3 investigators use electronic health record and trial data from patients with sepsis within 6 hours of hospital presentation to define clinical phenotypes that correlate with host-response patterns, sepsis biomarkers, mortality, and treatment effects.

This cohort study determines the risk-adjusted association between completing a 1-hour pediatric sepsis bundle and individual bundle elements with in-hospital mortality following statewide mandated care for pediatric sepsis in New York.