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This study of individual participant data from 6 pooled cohorts assesses whether resolution of elevated childhood non–high-density lipoprotein cholesterol (non–HDL-C) by adulthood is associated with reduced risk of clinical cardiovascular disease (CVD) events.

This cohort study investigates intensity-based physical activity (PA) trajectories from young to middle adulthood and examines the associations between PA trajectories and nonalcoholic fatty liver disease prevalence in midlife.

This cohort study evaluates whether cardiovascular fitness during the early periods of life is associated with morbidity and mortality outcomes and whether the outcomes vary by sex and race.

This cohort study of US adults using data from a longitudinal coronary study examines the association of trajectories of mean arterial pressure with brain health over 30 years of follow-up examination.

This study of pooled data from 9 US population-based cohorts assessed mortality risk and adverse cardiovascular and respiratory outcomes for chronic lung diseases among adults with normal spirometry vs preserved ratio impaired spirometry.

This cohort study evaluates the association between low-density lipoprotein cholesterol and development of cardiovascular disease later in life.

This cohort study aims to characterize age-related longitudinal low-density lipoprotein trajectories among US children.

This study used pooled cohort data to estimate the association between CT-assessed dysanapsis—a mismatch between airway tree caliber and lung size—and incident COPD in adults aged 60 years and older.

This cohort study assesses the association of chronic bronchitis with adverse respiratory health outcomes in adult ever smokers and never smokers.

This study used harmonized and pooled data from 4 US general population–based cohorts to determine the discriminative accuracy of various FEV₁:FVC fixed thresholds for predicting COPD-related hospitalization and mortality.

This 30-year prospective cohort study examines the association between lactation and progression to diabetes using biochemical testing both before and after pregnancy, accounting for prepregnancy cardiometabolic measures, gestational diabetes, and lifestyle behaviors.

This community-based cohort study examines whether coronary artery calcium in adults aged 32 to 46 years is associated with incident clinical coronary heart disease, cardiovascular disease, and all-cause mortality during 12.5 years of follow-up.

This community-based cohort study assesses which blood pressure components best determine incident cardiovascular disease events in young adults and determines whether these associations vary by race and age at blood pressure measurement.

This study of 2 population cohorts of African Americans compares hemoglobin A_1c values among those with vs without sickle cell trait to determine whether the trait interferes with identification of prediabetes or diabetes.

This study uses data from the Coronary Artery Risk Development in Young Adults (CARDIA) study to examine the association between cumulative lifetime exposure to marijuana and cognitive performance in middle age.

This observational study evaluates the effect of physical activity levels and television viewing habits of young adults over a 25-year period on cognitive function at midlife.

Naik and coauthors describe the relationship between sickle cell trait (SCT) and chronic kidney disease (CKD) and albuminuria in 2233 self-identified African Americans in the United States.

Allen and coauthors analyzed data from the prospective CARDIA cohort to identify common blood pressure (BP) trajectories throughout early adulthood and to determine their association with presence of subclinical atherosclerosis during middle age. Sarafidis and Bakris comment in an editorial.