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This secondary analysis of a randomized clinical trial assesses whether screening for prostate-specific antigen reduces prostate cancer mortality at 15-year follow-up.

This cohort study explores whether pregnancy-related predisposing factors for offspring neurodevelopmental conditions are associated with maternal genetic liability for attention-deficit/hyperactivity disorder (ADHD), autism, and schizophrenia

This Special Communication describes the development of the STROBE-MR Statement and includes the checklist of recommended items for inclusion in reports of mendelian randomization studies.

This mendelian randomization analysis investigates the potential bidirectional associations between the genetic liability for prescription opioid and other nonopioid pain medications and both major depressive disorder and anxiety and stress-related disorders using genetically based methods

This study uses mendelian randomization to estimate the associations between genetic variants related to reduced HMG-CoA reductase activity and epithelial ovarian cancer in the general population and in BRCA1/2 mutation carriers.

This genetic epidemiology study uses UK Biobank database data to estimate the association between genetic variants associated with lower low-density lipoprotein cholesterol (LDL-C), lower systolic blood pressure (SBP), or both and cardiovascular disease (CVD), defined as coronary death, nonfatal, myocardial infarction, or coronary revascularization.

This population-based cohort study assesses whether maternal polygenic risk scores for neurodevelopmental disorders are associated with early-life exposures previously linked to the disorders in women with available genotype data.

This population-based cohort study uses mendelian randomization to examine the association of body mass index (BMI) and alcohol consumption with levels of liver injury biomarkers and incident liver disease in adults in Denmark.

This cluster randomized trial evaluates the effect of a single prostate-specific antigen (PSA) screening test on 10-year prostate cancer–specific mortality among men aged 50 to 69 years treated at UK primary care practices.

This study uses mendelian randomization of candidate gene or genome-wide association studies to evaluate the association between inflammatory biomarkers and the risk of schizophrenia.

This mendelian randomization analysis of individual-participant data estimated the association between changes in levels of low-density lipoprotein cholesterol (and other lipoproteins) and risk of cardiovascular events due to CETP variants, alone and in combination with HMGCR variants.

This population-based cohort study examines whether genetic risk for attention-deficit/hyperactivity disorder is associated with symptom trajectories across childhood and adolescence, and whether higher genetic liability for attention-deficit/hyperactivity disorder is correlated with childhood multimorbidity.

This cohort study compares estimates of association between parental acetaminophen use and child conduct disorders for maternal prenatal, maternal postnatal, and partner use to understand the degree to which unmeasured behavioral variables might account for observed associations.

This genetic epidemiology study uses mendelian randomization to investigate associations between maternal body mass index and glucose and lipid levels and offspring birth weight between 1929 and 2013.