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  • Cardiac Function Before Sepsis and Clinical Outcomes

    Abstract Full Text
    JAMA. 2024; 331(17):1496-1499. 10.1001/jama.2024.3917

    This cohort study characterizes heterogeneity in cardiac function prior to sepsis and describes associations with hospitalization outcomes and mortality.

  • Association Between Preexisting Heart Failure With Reduced Ejection Fraction and Fluid Administration Among Patients With Sepsis

    Abstract Full Text
    open access
    ÁñÁ«ÊÓƵ Netw Open. 2022; 5(10):e2235331. 10.1001/jamanetworkopen.2022.35331

    This cohort study evaluates the association between preexisting heart failure with reduced ejection fraction, guideline-recommended intravenous fluid resuscitation, and mortality among patients with community-acquired sepsis and septic shock.

  • Effectiveness of Casirivimab-Imdevimab and Sotrovimab During a SARS-CoV-2 Delta Variant Surge: A Cohort Study and Randomized Comparative Effectiveness Trial

    Abstract Full Text
    open access is active quiz
    ÁñÁ«ÊÓƵ Netw Open. 2022; 5(7):e2220957. 10.1001/jamanetworkopen.2022.20957

    This combined cohort study and randomized comparative effectiveness trial examines the hospitalization and mortality outcomes among outpatients receiving monoclonal antibodies to treat COVID-19 caused by the SARS-CoV-2 Delta variant.

  • Feasibility of Embedding a Scalable, Virtually Enabled Biorepository in the Electronic Health Record for Precision Medicine

    Abstract Full Text
    open access
    ÁñÁ«ÊÓƵ Netw Open. 2021; 4(2):e2037739. 10.1001/jamanetworkopen.2020.37739

    This cohort study examines a virtually enabled biorepository and electronic health record (EHR)–embedded tool for use in precision medicine in patients with sepsis.

  • Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis

    Abstract Full Text
    free access
    JAMA. 2019; 321(20):2003-2017. 10.1001/jama.2019.5791

    In this study, Sepsis-3 investigators use electronic health record and trial data from patients with sepsis within 6 hours of hospital presentation to define clinical phenotypes that correlate with host-response patterns, sepsis biomarkers, mortality, and treatment effects.

  • Association of the Quick Sequential (Sepsis-Related) Organ Failure Assessment (qSOFA) Score With Excess Hospital Mortality in Adults With Suspected Infection in Low- and Middle-Income Countries

    Abstract Full Text
    free access
    JAMA. 2018; 319(21):2202-2211. 10.1001/jama.2018.6229

    This pooled cohort analysis assesses the association of quick Sequential (Sepsis-Related Organ Failure Assessment (qSOFA) score with excess hospital death among patients with suspected infection in low- to middle-income countries and compares the mortality association using qSOFA vs systemic inflammatory response syndrome (SIRS) criteria.