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JAMA
Research Letter
April 8, 2024
³§³Ù³Ü³Ù³ó¾±Ìý±õ²â±ð°ù,Ìý²Ñ±Ê±á; Jason N.ÌýKennedy, MS; Jacob C.ÌýJentzer, MD; Mourad H.ÌýSenussi, MD, MS; Christopher W.ÌýSeymour, MD, MSc
JAMA. 2024; 331(17):1496-1499. 10.1001/jama.2024.3917
This cohort study characterizes heterogeneity in cardiac function prior to sepsis and describes associations with hospitalization outcomes and mortality.
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ÁñÁ«ÊÓƵ Network Open
Original Investigation
Critical Care Medicine
October 7, 2022
Rachel E.ÌýPowell, MD; Jason N.ÌýKennedy, MS; Mourad H.ÌýSenussi, MD, MS; Ian J.ÌýBarbash, MD, MS; Christopher W.ÌýSeymour, MD, MSc
open access
ÁñÁ«ÊÓƵ Netw Open. 2022; 5(10):e2235331. 10.1001/jamanetworkopen.2022.35331
This cohort study evaluates the association between preexisting heart failure with reduced ejection fraction, guideline-recommended intravenous fluid resuscitation, and mortality among patients with community-acquired sepsis and septic shock.
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ÁñÁ«ÊÓƵ Network Open
Original Investigation
Infectious Diseases
July 14, 2022
David T.ÌýHuang, MD, MPH; Erin K.ÌýMcCreary, PharmD; J. Ryan Bariola, MD; Tami E.ÌýMinnier, MS; Richard J.ÌýWadas, MD; Judith A.ÌýShovel, BSN; Debbie Albin, BS; Oscar C.ÌýMarroquin, MD; Kevin E.ÌýKip, PhD; Kevin Collins, MBA; Mark Schmidhofer, MD; Mary Kay Wisniewski, MA; David A.ÌýNace, MD; Colleen Sullivan, MHA; Meredith Axe, BS; Russell Meyers, MBA; Alexandra Weissman, MD; William Garrard, PhD; Octavia M.ÌýPeck-Palmer, PhD; Alan Wells, MD, DMSc; Robert D.ÌýBart, MD; Anne Yang, MD; Lindsay R.ÌýBerry, PhD; Scott Berry, PhD; Amy M.ÌýCrawford, PhD; Anna McGlothlin, PhD; Tina Khadem, PharmD; Kelsey Linstrum, MS; Stephanie K.ÌýMontgomery, MS; Daniel Ricketts, MET; Jason N.ÌýKennedy, MS; Caroline J.ÌýPidro, BS; Anna Nakayama, MS; Rachel L.ÌýZapf, PhD; Paula L.ÌýKip, PhD; Ghady Haidar, MD; Graham M.ÌýSnyder, MD; Bryan J.ÌýMcVerry, MD; Donald M.ÌýYealy, MD; Derek C.ÌýAngus, MD, MPH; Christopher W.ÌýSeymour, MD, MSc
open access
is active quiz
ÁñÁ«ÊÓƵ Netw Open. 2022; 5(7):e2220957. 10.1001/jamanetworkopen.2022.20957
This combined cohort study and randomized comparative effectiveness trial examines the hospitalization and mortality outcomes among outpatients receiving monoclonal antibodies to treat COVID-19 caused by the SARS-CoV-2 Delta variant.
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ÁñÁ«ÊÓƵ Network Open
Original Investigation
Statistics and Research Methods
February 22, 2021
Kimberley M.ÌýDeMerle, MD; Jason N.ÌýKennedy, MS; Octavia M.ÌýPeck Palmer, PhD; Emily Brant, MD; Chung-Chou H.ÌýChang, PhD; Robert P.ÌýDickson, MD; David T.ÌýHuang, MD, MPH; Derek C.ÌýAngus, MD, MPH; Christopher W.ÌýSeymour, MD, MSc
open access
ÁñÁ«ÊÓƵ Netw Open. 2021; 4(2):e2037739. 10.1001/jamanetworkopen.2020.37739
This cohort study examines a virtually enabled biorepository and electronic health record (EHR)–embedded tool for use in precision medicine in patients with sepsis.
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JAMA
Original Investigation
Caring for the Critically Ill Patient
May 19, 2019
Christopher W.ÌýSeymour, MD, MSc; Jason N.ÌýKennedy, MS; Shu Wang, MS; Chung-Chou H.ÌýChang, PhD; Corrine F.ÌýElliott, MS; Zhongying Xu, MS; Scott Berry, PhD; Gilles Clermont, MD, MSc; Gregory Cooper, MD, PhD; Hernando Gomez, MD, MPH; David T.ÌýHuang, MD, MPH; John A.ÌýKellum, MD, FACP, MCCM; Qi Mi, PhD; Steven M.ÌýOpal, MD; Victor Talisa, MS; Tom van der Poll, MD, PhD; Shyam Visweswaran, MD, PhD; Yoram Vodovotz, PhD; Jeremy C.ÌýWeiss, MD, PhD; Donald M.ÌýYealy, MD, FACEP; Sachin Yende, MD, MS; Derek C.ÌýAngus, MD, MPH
free access
JAMA. 2019; 321(20):2003-2017. 10.1001/jama.2019.5791
In this study, Sepsis-3 investigators use electronic health record and trial data from patients with sepsis within 6 hours of hospital presentation to define clinical phenotypes that correlate with host-response patterns, sepsis biomarkers, mortality, and treatment effects.
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JAMA
Original Investigation
June 5, 2018
Kristina E.ÌýRudd, MD, MPH; Christopher W.ÌýSeymour, MD, MSc; Adam R.ÌýAluisio, MD, MSc; Marc E.ÌýAugustin, MD; Danstan S.ÌýBagenda, PhD; Abi Beane, MSc; Jean Claude Byiringiro, MD; Chung-Chou H.ÌýChang, PhD; L. Nathalie Colas, MD; Nicholas P. J.ÌýDay, MD, PhD; A. Pubudu De Silva, MD; Arjen M.ÌýDondorp, MD, PhD; Martin W.ÌýDünser, MD; M. Abul Faiz, MBBS, PhD; Donald S.ÌýGrant, MBChB, MPH; Rashan Haniffa, MD; Nguyen Van Hao, PhD; Jason N.ÌýKennedy, MS; Adam C.ÌýLevine, MD, MPH; Direk Limmathurotsakul, MD, PhD; Sanjib Mohanty, MD; François Nosten, MD, PhD; Alfred Papali, MD; Andrew J.ÌýPatterson, MD, PhD; John S.ÌýSchieffelin, MD, MSPH; Jeffrey G.ÌýShaffer, PhD; Duong Bich Thuy, MD; C. Louise Thwaites, PhD; Olivier Urayeneza, MD; Nicholas J.ÌýWhite, MD, DSc; T. Eoin West, MD, MPH; Derek C.ÌýAngus, MD, MPH; for the Sepsis Assessment and Identification in Low Resource Settings (SAILORS) Collaboration
free access
JAMA. 2018; 319(21):2202-2211. 10.1001/jama.2018.6229
This pooled cohort analysis assesses the association of quick Sequential (Sepsis-Related Organ Failure Assessment (qSOFA) score with excess hospital death among patients with suspected infection in low- to middle-income countries and compares the mortality association using qSOFA vs systemic inflammatory response syndrome (SIRS) criteria.