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JAMA Cardiology
Brief Report
May 29, 2024
John W.ÌýOstrominski,ÌýMD; Stephen J.ÌýGreene,ÌýMD; Ravi B.ÌýPatel,ÌýMD, MSc; Nicole C.ÌýSolomon,ÌýPhD; KarenÌýChiswell,ÌýPhD; Adam D.ÌýDeVore,ÌýMD, MHS; JavedÌýButler,ÌýMD, MPH, MBA; Paul A.ÌýHeidenreich,ÌýMD; Joanna C.ÌýHuang,ÌýPharmD; Michelle M.ÌýKittleson,ÌýMD, PhD; Karen E.ÌýJoynt Maddox,ÌýMD, MPH; Karthik K.ÌýLinganathan,ÌýMD; James J.ÌýMcDermott,ÌýPhD; Anjali TikuÌýOwens,ÌýMD; Pamela N.ÌýPeterson,ÌýMD, MSPH; Scott D.ÌýSolomon,ÌýMD; OrlyÌýVardeny,ÌýPharmD, MS; Clyde W.ÌýYancy,ÌýMD, MSc; Gregg C.ÌýFonarow,ÌýMD; MuthiahÌýVaduganathan,ÌýMD, MPH
online first
JAMA Cardiol. 2024; 10.1001/jamacardio.2024.1108
This cohort study examines the incidence of dialysis and acute kidney injury among Medicare beneficiaries after hospitalization for heart failure.
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JAMA Cardiology
Research Letter
April 24, 2024
AhmedÌýSayed,ÌýMBBS; DmitryÌýAbramov,ÌýMD; Gregg C.ÌýFonarow,ÌýMD; Mamas A.ÌýMamas,ÌýMD, PhD; OferÌýKobo,ÌýMD; JavedÌýButler,ÌýMD, MPH, MBA; MaratÌýFudim,ÌýMD, MHS
online first
JAMA Cardiol. 2024; 10.1001/jamacardio.2024.0615
This cohort study evaluates recent reversals in declines in cardiovascular mortality and whether they vary across sociodemographic categories.
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JAMA Cardiology
Original Investigation
September 27, 2023
John W.ÌýOstrominski,ÌýMD; Suzanne V.ÌýArnold,ÌýMD, MHA; JavedÌýButler,ÌýMD, MPH, MBA; Gregg C.ÌýFonarow,ÌýMD; Jamie S.ÌýHirsch,ÌýMD; Swetha R.ÌýPalli,ÌýMS; Bonnie M. K.ÌýDonato,ÌýPhD; Christina M.ÌýParrinello,ÌýPhD, MPH; ThomasÌýO’Connell,ÌýMA; Eric B.ÌýCollins,ÌýMPH; Jonathan J.ÌýWoolley,ÌýMS; Mikhail N.ÌýKosiborod,ÌýMD; MuthiahÌýVaduganathan,ÌýMD, MPH
JAMA Cardiol. 2023; 8(11):1050-1060. 10.1001/jamacardio.2023.3241
This cohort study investigates the prevalence and overlap of cardiac, renal, and metabolic conditions in US adults, using data from the National Health and Nutrition Examination Survey.
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JAMA Cardiology
Original Investigation
May 24, 2023
JavedÌýButler,ÌýMD, MPH, MBA; Muhammad ShariqÌýUsman,ÌýMD; GerasimosÌýFilippatos,ÌýMD, PhD; João PedroÌýFerreira,ÌýMD, PhD; MichaelÌýBöhm,ÌýMD; MartinaÌýBrueckmann,ÌýMD; James L.ÌýJanuzzi,ÌýMD; SanjayÌýKaul,ÌýMD; Ileana L.ÌýPiña,ÌýMD, MPH; PiotrÌýPonikowski,ÌýMD, PhD; MicheleÌýSenni,ÌýMD; MikhailÌýSumin,ÌýMD, PhD; SubodhÌýVerma,ÌýMD, PhD; LilianaÌýZaremba-Pechmann,ÌýPhD; Stuart J.ÌýPocock,ÌýPhD; MiltonÌýPacker,ÌýMD; StefanÌýAnker,ÌýMD, PhD
open access
JAMA Cardiol. 2023; 8(7):640-649. 10.1001/jamacardio.2023.1090
This post hoc analysis of a randomized clinical trial evaluates the safety and efficacy of empagliflozin in patients with heart failure and preserved ejection fraction who are taking diuretics.
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JAMA Cardiology
Original Investigation
May 22, 2023
Jacob B.ÌýPierce,ÌýMD, MPH; MuthiahÌýVaduganathan,ÌýMD, MPH; Gregg C.ÌýFonarow,ÌýMD; UchechukwuÌýIkeaba,ÌýMS; KarenÌýChiswell,ÌýPhD; JavedÌýButler,ÌýMD, MPH, MBA; Adam D.ÌýDeVore,ÌýMD, MHS; Paul A.ÌýHeidenreich,ÌýMD, MS; Joanna C.ÌýHuang,ÌýPharmD; Michelle M.ÌýKittleson,ÌýMD, PhD; Karen E.ÌýJoynt Maddox,ÌýMD, MPH; Karthik K.ÌýLinganathan,ÌýMD; James J.ÌýMcDermott,ÌýPhD; Anjali TikuÌýOwens,ÌýMD; Pamela N.ÌýPeterson,ÌýMD, MSPH; Scott D.ÌýSolomon,ÌýMD; OrlyÌýVardeny,ÌýPharmD; Clyde W.ÌýYancy,ÌýMD, MSc; Stephen J.ÌýGreene,ÌýMD
free access
JAMA Cardiol. 2023; 8(7):652-661. 10.1001/jamacardio.2023.1266
This cohort study characterizes patterns of sodium-glucose cotransporter-2 inhibitor use among eligible patients hospitalized for heart failure with reduced ejection fraction (HFrEF).
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JAMA Cardiology
Original Investigation
November 5, 2022
Khawaja M.ÌýTalha,ÌýMBBS; JavedÌýButler,ÌýMD, MPH, MBA; Stephen J.ÌýGreene,ÌýMD; RahulÌýAggarwal,ÌýMD; Stefan D.ÌýAnker,ÌýMD, PhD; Brian L.ÌýClaggett,ÌýPhD; Scott D.ÌýSolomon,ÌýMD; John J. V.ÌýMcMurray,ÌýMD; MuthiahÌýVaduganathan,ÌýMD, MPH; Gregg C.ÌýFonarow,ÌýMD
free access
JAMA Cardiol. 2022; 8(1):66-73. 10.1001/jamacardio.2022.4348
This decision analytical model study quantifies the estimated US population-level impact of reducing heart failure events with sodium-glucose cotransporter-2 inhibitors in left ventricular ejection fraction more than 40%.
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JAMA Cardiology
Original Investigation
September 21, 2022
João PedroÌýFerreira,ÌýMD, PhD; FaiezÌýZannad,ÌýMD, PhD; JavedÌýButler,ÌýMD, MPH; GerasimosÌýFilippatos,ÌýMD, PhD; Stuart J.ÌýPocock,ÌýPhD; MartinaÌýBrueckmann,ÌýMD; DominikÌýSteubl,ÌýMD; ElkeÌýSchueler,ÌýMSc, Dipl-Math; Stefan D.ÌýAnker,ÌýMD, PhD; MiltonÌýPacker,ÌýMD
open access
JAMA Cardiol. 2022; 7(11):1148-1159. 10.1001/jamacardio.2022.2924
This post hoc analysis of a randomized clinical trial of patients with heart failure evaluates the association of empagliflozin with albuminuria levels in study participants.
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JAMA Cardiology
Review
August 31, 2022
JosephineÌýHarrington,ÌýMD; Mark C.ÌýPetrie,ÌýMD; Stefan D.ÌýAnker,ÌýMD, PhD; Deepak L.ÌýBhatt,ÌýMD, MPH; W. SchuylerÌýJones,ÌýMD; Jacob A.ÌýUdell,ÌýMD; Adrian F.ÌýHernandez,ÌýMD, MHS; JavedÌýButler,ÌýMD, MPH, MBA
is active quiz
JAMA Cardiol. 2022; 7(10):1067-1075. 10.1001/jamacardio.2022.2847
This narrative review discusses trials evaluating the use of existing chronic heart failure therapies in individuals with recent myocardial infarction and the development of new treatments targeting this population.
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JAMA
Viewpoint
August 18, 2022
Muhammad ShahzebÌýKhan,ÌýMD, MSc; JavedÌýButler,ÌýMD, MPH, MBA
JAMA. 2022; 328(10):923-924. 10.1001/jama.2022.13551
This Viewpoint explores how patient-reported response to treatment informs understanding of clinically meaningful outcomes to help establish patient expectations, inform clinical decision-making, and ensure treatment is sound.
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JAMA Cardiology
Original Investigation
July 27, 2022
VardhmanÌýJain,ÌýMD; Abdul Mannan KhanÌýMinhas,ÌýMD; Alanna A.ÌýMorris,ÌýMD, MSc; Stephen J.ÌýGreene,ÌýMD; AmbarishÌýPandey,ÌýMD, MSCS; Sadiya S.ÌýKhan,ÌýMD; Gregg C.ÌýFonarow,ÌýMD; Robert J.ÌýMentz,ÌýMD; JavedÌýButler,ÌýMD, MPH, MBA; Muhammad ShahzebÌýKhan,ÌýMD, MSc
free access
JAMA Cardiol. 2022; 7(9):900-904. 10.1001/jamacardio.2022.2213
This cohort study assesses trends in heart failure–related mortality in Black, Hispanic, and White young adults.
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JAMA Cardiology
Review
January 5, 2022
Muhammad ShahzebÌýKhan,ÌýMD, MSc; George L.ÌýBakris,ÌýMD; IzzaÌýShahid,ÌýMBBS; Matthew R.ÌýWeir,ÌýMD; JavedÌýButler,ÌýMD, MPH, MBA
is active quiz
JAMA Cardiol. 2022; 7(5):549-555. 10.1001/jamacardio.2021.5151
This narrative review explores the use of eGFR slope in clinical trials, its strengths and limitations, and the implications of adopting it as a viable outcome in cardiovascular outcome trials.
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JAMA
Viewpoint
November 15, 2021
Stephen J.ÌýGreene,ÌýMD; JavedÌýButler,ÌýMD, MPH, MBA; Gregg C.ÌýFonarow,ÌýMD
JAMA. 2021; 326(22):2261-2262. 10.1001/jama.2021.20739
This Viewpoint frames the clinical event risk for heart failure in the context of the approach used in the 2018 ACC/AHA cholesterol guidelines.
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JAMA
Original Investigation
July 27, 2021
Adam D.ÌýDeVore,ÌýMD, MHS; Bradi B.ÌýGranger,ÌýPhD, RN; Gregg C.ÌýFonarow,ÌýMD; Hussein R.ÌýAl-Khalidi,ÌýPhD; Nancy M.ÌýAlbert,ÌýPhD; Eldrin F.ÌýLewis,ÌýMD, MPH; JavedÌýButler,ÌýMD, MPH, MBA; Ileana L.ÌýPiña,ÌýMD, MPH; Larry A.ÌýAllen,ÌýMD, MHS; Clyde W.ÌýYancy,ÌýMD; Lauren B.ÌýCooper,ÌýMD, MHS; G. MichaelÌýFelker,ÌýMD, MHS; Lisa A.ÌýKaltenbach,ÌýMS; A. ThomasÌýMcRae,ÌýMD; David E.ÌýLanfear,ÌýMD, MS; Robert W.ÌýHarrison,ÌýMD; MagheeÌýDisch,ÌýMSN, RN; DanÌýAriely,ÌýPhD; Julie M.ÌýMiller,ÌýPhD, MSPH; Christopher B.ÌýGranger,ÌýMD; Adrian F.ÌýHernandez,ÌýMD, MHS
free access
is active quiz
JAMA. 2021; 326(4):314-323. 10.1001/jama.2021.8844
This cluster randomized trial evaluates the effect of a hospital and postdischarge quality improvement intervention vs usual care on time to heart failure rehospitalization or death, and quality of care, among patients with heart failure and reduced ejection fraction in the US.
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JAMA Cardiology
Viewpoint
March 31, 2021
Stephen J.ÌýGreene,ÌýMD; JavedÌýButler,ÌýMD, MPH, MBA; Gregg C.ÌýFonarow,ÌýMD
JAMA Cardiol. 2021; 6(7):743-744. 10.1001/jamacardio.2021.0496
This Viewpoint advocates for expanded use of quadruple therapy in patients with heart failure with reduced ejection fraction.
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JAMA Cardiology
Original Investigation
March 24, 2021
Stephen J.ÌýGreene,ÌýMD; JavedÌýButler,ÌýMD, MPH, MBA; John A.ÌýSpertus,ÌýMD, MPH; Anne S.ÌýHellkamp,ÌýMS; MuthiahÌýVaduganathan,ÌýMD, MPH; Adam D.ÌýDeVore,ÌýMD, MHS; Nancy M.ÌýAlbert,ÌýPhD; Carol I.ÌýDuffy,ÌýDO; J. HerbertÌýPatterson,ÌýPharmD; LaineÌýThomas,ÌýPhD; Fredonia B.ÌýWilliams,ÌýEdD; Adrian F.ÌýHernandez,ÌýMD, MHS; Gregg C.ÌýFonarow,ÌýMD
free access
has multimedia
JAMA Cardiol. 2021; 6(5):522-531. 10.1001/jamacardio.2021.0372
This registry-based cohort study compares the capture of clinically meaningful health status changes between physician-assigned New York Heart Association functional class and patient-reported outcome in Kansas City Cardiomyopathy Questionnaire Overall Summary Score for patients with chronic heart failure with reduced ejection fraction.
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JAMA Cardiology
Research Letter
November 25, 2020
Michael C.ÌýHonigberg,ÌýMD, MPP; Ravi B.ÌýPatel,ÌýMD; AmbarishÌýPandey,ÌýMD; Gregg C.ÌýFonarow,ÌýMD; JavedÌýButler,ÌýMD, MPH, MBA; Darren K.ÌýMcGuire,ÌýMD, MHSc; MuthiahÌýVaduganathan,ÌýMD, MPH
free access
JAMA Cardiol. 2020; 6(3):354-357. 10.1001/jamacardio.2020.5921
This cohort study evaluates the association of heart failure and ischemic heart disease with diabetes complications.
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JAMA Cardiology
Original Investigation
November 18, 2020
Sean P.ÌýCollins,ÌýMD, MSc; DandanÌýLiu,ÌýPhD; Cathy A.ÌýJenkins,ÌýMSc; Alan B.ÌýStorrow,ÌýMD; Phillip D.ÌýLevy,ÌýMD, MPH; Peter S.ÌýPang,ÌýMD; Anna MarieÌýChang,ÌýMD; DouglasÌýChar,ÌýMD; Deborah J.ÌýDiercks,ÌýMD; Gregory J.ÌýFermann,ÌýMD; Jin H.ÌýHan,ÌýMD; BrianÌýHiestand,ÌýMD, MPH; ChristopherÌýHogan,ÌýMD; Christina J.ÌýKampe,ÌýMAcc; YosefÌýKhan,ÌýMD, PhD, MPH; SangilÌýLee,ÌýMD; JoAnnÌýLindenfeld,ÌýMD; JenniferÌýMartindale,ÌýMD; Candace D.ÌýMcNaughton,ÌýMD, PhD; Karen F.ÌýMiller,ÌýRN, BSN; CarolynÌýMiller-Reilly,ÌýPhD, RN; KellyÌýMoser,ÌýBA; W. FrankÌýPeacock,ÌýMD; ChadÌýRobichaux,ÌýMPH; RussellÌýRothman,ÌýMD, MPH; JonÌýSchrock,ÌýMD; Wesley H.ÌýSelf,ÌýMD, MPH; Adam J.ÌýSinger,ÌýMD; Sarah A.ÌýSterling,ÌýMD; Michael J.ÌýWard,ÌýMD, PhD; CherylÌýWalsh; JavedÌýButler,ÌýMD, MPH, MBA
free access
JAMA Cardiol. 2020; 6(2):200-208. 10.1001/jamacardio.2020.5763
This randomized clinical trial examines intervention to promote self-care in patients with acute heart failure who are discharged from the emergency department.
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JAMA Cardiology
Original Investigation
November 13, 2020
MuthiahÌýVaduganathan,ÌýMD, MPH; Stephen J.ÌýGreene,ÌýMD; ShuaiqiÌýZhang,ÌýMS; MariaÌýGrau-Sepulveda,ÌýMD; Adam D.ÌýDeVore,ÌýMD, MHS; JavedÌýButler,ÌýMD, MPH, MBA; Paul A.ÌýHeidenreich,ÌýMD; Joanna C.ÌýHuang,ÌýPharmD; Michelle M.ÌýKittleson,ÌýMD, PhD; Karen E.ÌýJoynt Maddox,ÌýMD, MPH; James J.ÌýMcDermott,ÌýPhD; Anjali TikuÌýOwens,ÌýMD; Pamela N.ÌýPeterson,ÌýMD, MPH, MSPH; Scott D.ÌýSolomon,ÌýMD; OrlyÌýVardeny,ÌýPharmD; Clyde W.ÌýYancy,ÌýMD, MSc; Gregg C.ÌýFonarow,ÌýMD
free access
JAMA Cardiol. 2020; 6(3):267-275. 10.1001/jamacardio.2020.5864
This cohort study evaluates candidacy for initiation of dapagliflozin based on the US Food and Drug Administration label among contemporary US patients with heart failure with reduced ejection fraction and describes potential barriers to therapeutic optimizations.
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JAMA
Original Investigation
October 20, 2020
Paul W.ÌýArmstrong,ÌýMD; Carolyn S. P.ÌýLam,ÌýMBBS, PhD; Kevin J.ÌýAnstrom,ÌýPhD; JustinÌýEzekowitz,ÌýMBBCh, MSc; Adrian F.ÌýHernandez,ÌýMD, MHS; Christopher M.ÌýO’Connor,ÌýMD; BurkertÌýPieske,ÌýMD; PiotrÌýPonikowski,ÌýMD, PhD; Sanjiv J.ÌýShah,ÌýMD; Scott D.ÌýSolomon,ÌýMD; Adriaan A.ÌýVoors,ÌýMD; LilinÌýShe,ÌýPhD; VanjaÌýVlajnic,ÌýMS, MAS; FrancineÌýCarvalho,ÌýMD, PhD; LukeÌýBamber,ÌýMSc; Robert O.ÌýBlaustein,ÌýMD, PhD; LotharÌýRoessig,ÌýMD; JavedÌýButler,ÌýMD, MPH, MBA; VITALITY-HFpEF Study Group
free access
JAMA. 2020; 324(15):1512-1521. 10.1001/jama.2020.15922
This randomized trial compares the effect of the oral soluble guanylate cyclase stimulator vericiguat (15 vs 10 mg/d) vs placebo on change in disease-specific physical function at 24 weeks among patients with HFpEF.
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ÁñÁ«ÊÓƵ Network Open
Original Investigation
Statistics and Research Methods
August 5, 2020
Muhammad ShahzebÌýKhan,ÌýMD, MSc; Gregg C.ÌýFonarow,ÌýMD; TimÌýFriede,ÌýPhD; NomanÌýLateef,ÌýMD; Safi U.ÌýKhan,ÌýMD; Stefan D.ÌýAnker,ÌýMD, PhD; Frank E.ÌýHarrellÌýJr,ÌýPhD; JavedÌýButler,ÌýMD, MPH, MBA
open access
ÁñÁ«ÊÓƵ Netw Open. 2020; 3(8):e2012469. 10.1001/jamanetworkopen.2020.12469
This cross-sectional study describes application of the reverse fragility index in establishing the clinical relevance of published clinical trials with null results.