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  • Kidney Outcomes Among Medicare Beneficiaries After Hospitalization for Heart Failure

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    JAMA Cardiol. 2024; 10.1001/jamacardio.2024.1108

    This cohort study examines the incidence of dialysis and acute kidney injury among Medicare beneficiaries after hospitalization for heart failure.

  • Reversals in the Decline of Heart Failure Mortality in the US, 1999 to 2021

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    JAMA Cardiol. 2024; 10.1001/jamacardio.2024.0615

    This cohort study evaluates recent reversals in declines in cardiovascular mortality and whether they vary across sociodemographic categories.

  • Prevalence and Overlap of Cardiac, Renal, and Metabolic Conditions in US Adults, 1999-2020

    Abstract Full Text
    JAMA Cardiol. 2023; 8(11):1050-1060. 10.1001/jamacardio.2023.3241

    This cohort study investigates the prevalence and overlap of cardiac, renal, and metabolic conditions in US adults, using data from the National Health and Nutrition Examination Survey.

  • Safety and Efficacy of Empagliflozin and Diuretic Use in Patients with Heart Failure and Preserved Ejection Fraction: A Post Hoc Analysis of the EMPEROR-Preserved Trial

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    JAMA Cardiol. 2023; 8(7):640-649. 10.1001/jamacardio.2023.1090

    This post hoc analysis of a randomized clinical trial evaluates the safety and efficacy of empagliflozin in patients with heart failure and preserved ejection fraction who are taking diuretics.

  • Contemporary Use of Sodium-Glucose Cotransporter-2 Inhibitor Therapy Among Patients Hospitalized for Heart Failure With Reduced Ejection Fraction in the US: The Get With The Guidelines–Heart Failure Registry

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    JAMA Cardiol. 2023; 8(7):652-661. 10.1001/jamacardio.2023.1266

    This cohort study characterizes patterns of sodium-glucose cotransporter-2 inhibitor use among eligible patients hospitalized for heart failure with reduced ejection fraction (HFrEF).

  • Population-Level Implications of Sodium-Glucose Cotransporter-2 Inhibitors for Heart Failure With Preserved Ejection Fraction in the US

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    JAMA Cardiol. 2022; 8(1):66-73. 10.1001/jamacardio.2022.4348

    This decision analytical model study quantifies the estimated US population-level impact of reducing heart failure events with sodium-glucose cotransporter-2 inhibitors in left ventricular ejection fraction more than 40%.

  • Association of Empagliflozin Treatment With Albuminuria Levels in Patients With Heart Failure: A Secondary Analysis of EMPEROR-Pooled

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    JAMA Cardiol. 2022; 7(11):1148-1159. 10.1001/jamacardio.2022.2924

    This post hoc analysis of a randomized clinical trial of patients with heart failure evaluates the association of empagliflozin with albuminuria levels in study participants.

  • Evaluating the Application of Chronic Heart Failure Therapies and Developing Treatments in Individuals With Recent Myocardial Infarction: A Review

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    JAMA Cardiol. 2022; 7(10):1067-1075. 10.1001/jamacardio.2022.2847

    This narrative review discusses trials evaluating the use of existing chronic heart failure therapies in individuals with recent myocardial infarction and the development of new treatments targeting this population.

  • Stability of Changes in Health Status: Next Step in Comprehensively Assessing Patient-Reported Outcomes

    Abstract Full Text
    JAMA. 2022; 328(10):923-924. 10.1001/jama.2022.13551

    This Viewpoint explores how patient-reported response to treatment informs understanding of clinically meaningful outcomes to help establish patient expectations, inform clinical decision-making, and ensure treatment is sound.

  • Demographic and Regional Trends of Heart Failure–Related Mortality in Young Adults in the US, 1999-2019

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    JAMA Cardiol. 2022; 7(9):900-904. 10.1001/jamacardio.2022.2213

    This cohort study assesses trends in heart failure–related mortality in Black, Hispanic, and White young adults.

  • Potential Role and Limitations of Estimated Glomerular Filtration Rate Slope Assessment in Cardiovascular Trials: A Review

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    JAMA Cardiol. 2022; 7(5):549-555. 10.1001/jamacardio.2021.5151

    This narrative review explores the use of eGFR slope in clinical trials, its strengths and limitations, and the implications of adopting it as a viable outcome in cardiovascular outcome trials.

  • Contextualizing Risk Among Patients With Heart Failure

    Abstract Full Text
    JAMA. 2021; 326(22):2261-2262. 10.1001/jama.2021.20739

    This Viewpoint frames the clinical event risk for heart failure in the context of the approach used in the 2018 ACC/AHA cholesterol guidelines.

  • Effect of a Hospital and Postdischarge Quality Improvement Intervention on Clinical Outcomes and Quality of Care for Patients With Heart Failure With Reduced Ejection Fraction: The CONNECT-HF Randomized Clinical Trial

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    JAMA. 2021; 326(4):314-323. 10.1001/jama.2021.8844

    This cluster randomized trial evaluates the effect of a hospital and postdischarge quality improvement intervention vs usual care on time to heart failure rehospitalization or death, and quality of care, among patients with heart failure and reduced ejection fraction in the US.

  • Simultaneous or Rapid Sequence Initiation of Quadruple Medical Therapy for Heart Failure—Optimizing Therapy With the Need for Speed

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    JAMA Cardiol. 2021; 6(7):743-744. 10.1001/jamacardio.2021.0496

    This Viewpoint advocates for expanded use of quadruple therapy in patients with heart failure with reduced ejection fraction.

  • Comparison of New York Heart Association Class and Patient-Reported Outcomes for Heart Failure With Reduced Ejection Fraction

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    JAMA Cardiol. 2021; 6(5):522-531. 10.1001/jamacardio.2021.0372

    This registry-based cohort study compares the capture of clinically meaningful health status changes between physician-assigned New York Heart Association functional class and patient-reported outcome in Kansas City Cardiomyopathy Questionnaire Overall Summary Score for patients with chronic heart failure with reduced ejection fraction.

  • Trends in Hospitalizations for Heart Failure and Ischemic Heart Disease Among US Adults With Diabetes

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    JAMA Cardiol. 2020; 6(3):354-357. 10.1001/jamacardio.2020.5921

    This cohort study evaluates the association of heart failure and ischemic heart disease with diabetes complications.

  • Effect of a Self-care Intervention on 90-Day Outcomes in Patients With Acute Heart Failure Discharged From the Emergency Department: A Randomized Clinical Trial

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    JAMA Cardiol. 2020; 6(2):200-208. 10.1001/jamacardio.2020.5763

    This randomized clinical trial examines intervention to promote self-care in patients with acute heart failure who are discharged from the emergency department.

  • Applicability of US Food and Drug Administration Labeling for Dapagliflozin to Patients With Heart Failure With Reduced Ejection Fraction in US Clinical Practice: The Get With the Guidelines–Heart Failure (GWTG-HF) Registry

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    JAMA Cardiol. 2020; 6(3):267-275. 10.1001/jamacardio.2020.5864

    This cohort study evaluates candidacy for initiation of dapagliflozin based on the US Food and Drug Administration label among contemporary US patients with heart failure with reduced ejection fraction and describes potential barriers to therapeutic optimizations.

  • Effect of Vericiguat vs Placebo on Quality of Life in Patients With Heart Failure and Preserved Ejection Fraction: The VITALITY-HFpEF Randomized Clinical Trial

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    JAMA. 2020; 324(15):1512-1521. 10.1001/jama.2020.15922

    This randomized trial compares the effect of the oral soluble guanylate cyclase stimulator vericiguat (15 vs 10 mg/d) vs placebo on change in disease-specific physical function at 24 weeks among patients with HFpEF.

  • Application of the Reverse Fragility Index to Statistically Nonsignificant Randomized Clinical Trial Results

    Abstract Full Text
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    ÁñÁ«ÊÓƵ Netw Open. 2020; 3(8):e2012469. 10.1001/jamanetworkopen.2020.12469

    This cross-sectional study describes application of the reverse fragility index in establishing the clinical relevance of published clinical trials with null results.