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  • JAMA Original Investigation
    February 7, 2024

    Time to Treatment With Intravenous Thrombolysis Before Thrombectomy and Functional Outcomes in Acute Ischemic Stroke: A Meta-Analysis

    Johannes听Kaesmacher,听MD, PhD; Fabiano听Cavalcante,听MD; Manon听Kappelhof,听MD, PhD; Kilian M.听Treurniet,听MD, PhD; Leon听Rinkel,听MD; Jianmin听Liu,听MD; Bernard听Yan,听DMedSci; Wenjie听Zi,听MD; Kazumi听Kimura,听MD, PhD; Omer F.听Eker,听MD, PhD; Yongwei听Zhang,听MD; Eike I.听Piechowiak,听MD; Wim听van Zwam,听MD, PhD; Sheng听Liu,听MD; Daniel听Strbian,听MD, MSc, PhD; Maarten听Uyttenboogaart,听MD, PhD; Tomas听Dobrocky,听MD; Zhongrong听Miao,听MD; Kentaro听Suzuki,听MD, PhD; Lei听Zhang,听MD; Robert听van Oostenbrugge,听MD, PhD; Thomas R.听Meinel,听MD, PhD; Changwei听Guo,听MD; David听Seiffge,听MD; Congguo听Yin,听MD; Lukas听B眉tikofer,听PhD; Hester听Lingsma,听PhD; Daan听Nieboer,听PhD; Pengfei听Yang,听MD; Peter听Mitchell,听MMed; Charles听Majoie,听MD, PhD; Urs听Fischer,听MD, MSc; Yvo听Roos,听MD, PhD; Jan听Gralla,听MD, MSc; IRIS Collaborators
    Abstract Full Text
    JAMA. 2024; 331(9):764-777. 10.1001/jama.2024.0589

    This individual participant data meta-analysis assesses treatment time from stroke symptom onset and disability level after treatment with intravenous thrombolysis plus thrombectomy vs thrombectomy alone among patients who presented directly at thrombectomy-capable stroke centers.

  • 榴莲视频 Network Open Original Investigation Neurology
    May 1, 2023

    Association Between Intravenous Thrombolysis and Clinical Outcomes Among Patients With Ischemic Stroke and Unsuccessful Mechanical Reperfusion

    Tobias D.听Faizy,听MD; Gabriel听Broocks,听MD; Jeremy J.听Heit,听MD, PhD; Helge听Kniep,听MD; Fabian听Flottmann,听MD; Lukas听Meyer,听MD; Peter听Sporns,听MD; Uta听Hanning,听MD; Johannes听Kaesmacher,听MD; Milani听Deb-Chatterji,听MD; Philipp听Vollmuth,听MD; Maarten G.听Lansberg,听MD, PhD; Gregory W.听Albers,听MD; Urs听Fischer,听MD; Max听Wintermark,听MD; G枚tz听Thomalla,听MD; Jens听Fiehler,听MD; Laurens听Winkelmeier,听MD; German Stroke Registry鈥揈ndovascular Treatment Investigators
    Abstract Full Text
    open access
    榴莲视频 Netw Open. 2023; 6(5):e2310213. 10.1001/jamanetworkopen.2023.10213

    This cohort study investigates the potential treatment benefit of intravenous thrombolysis in patients with acute ischemic stroke due to large-vessel occlusion in whom successful mechanical reperfusion was not achieved.

  • 榴莲视频 Neurology Original Investigation
    January 3, 2023

    Intravenous Thrombolysis in Patients With Ischemic Stroke and Recent Ingestion of Direct Oral Anticoagulants

    Thomas R.听Meinel,听MD; Duncan听Wilson,听PhD; Henrik听Gensicke,听MD; Jan F.听Scheitz,听MD; Peter听Ringleb,听MD; Ioana听Goganau,听MD; Johannes听Kaesmacher,听MD; Hee-Joon听Bae,听MD; Do Yeon听Kim,听MD; Pawel听Kermer,听MD; Kentaro听Suzuki,听MD; Kazumi听Kimura,听MD; Kosmas听Macha,听MD; Masatoshi听Koga,听MD; Shinichi听Wada,听MD; Valerian听Altersberger,听MD; Alexander听Salerno,听MD; Logesh听Palanikumar,听MD; Andrea听Zini,听MD; Stefano听Forlivesi,听MD; Lars听Kellert,听MD; Johannes听Wischmann,听MD; Espen S.听Kristoffersen,听MD, PhD; James听Beharry,听MD; P. Alan听Barber,听PhD; Jae Beom听Hong,听MD; Carlo听Cereda,听MD; Eckhard听Schlemm,听MBBS, PhD; Yusuke听Yakushiji,听MD; Sven听Poli,听MD, MSc; Ronen听Leker,听MD; Michele听Romoli,听MD; Marialuisa听Zedde,听MD; Sami听Curtze,听MD; Benno听Ikenberg,听MD; Timo听Uphaus,听MD; David听Giannandrea,听MD; Pere Cardona听Portela,听MD; Roland听Veltkamp,听MD; Annemarei听Ranta,听PhD; Marcel听Arnold,听MD; Urs听Fischer,听MD; Jae-Kwan听Cha,听MD; Teddy Y.听Wu,听PhD; Jan C.听Purrucker,听MD, MSc; David J.听Seiffge,听MD; International DOAC-IVT, TRISP, and CRCS-K-NIH Collaboration; DOAC-IVT Writing Group
    Abstract Full Text
    open access
    榴莲视频 Neurol. 2023; 80(3):233-243. 10.1001/jamaneurol.2022.4782

    This cohort study evaluates the risk of symptomatic intracranial hemorrhage associated with use of intravenous thrombolysis in patients with recent direct oral anticoagulant ingestion.

  • 榴莲视频 Neurology Original Investigation
    November 8, 2021

    Noncontrast Computed Tomography vs Computed Tomography Perfusion or Magnetic Resonance Imaging Selection in Late Presentation of Stroke With Large-Vessel Occlusion

    Thanh N.听Nguyen,听MD; Mohamad听Abdalkader,听MD; Simon听Nagel,听MD; Muhammad M.听Qureshi,听MPH; Marc听Ribo,听MD, PhD; Francois听Caparros,听MD; Diogo C.听Haussen,听MD; Mahmoud H.听Mohammaden,听MD, MSc; Sunil A.听Sheth,听MD; Santiago听Ortega-Gutierrez,听MD, MSc; James E.听Siegler,听MD; Syed听Zaidi,听MD; Marta听Olive-Gadea,听MD; Hilde听Henon,听MD, PhD; Markus A.听M枚hlenbruch,听MD; Alicia C.听Castonguay,听PhD; Stefania听Nannoni,听MD; Johannes听Kaesmacher,听MD; Ajit S.听Puri,听MD; Fatih听Seker,听MD; Mudassir听Farooqui,听MD, MPH; Sergio听Salazar-Marioni,听MD; Anna L.听Kuhn,听MD; Artem听Kaliaev,听MD; Behzad听Farzin,听MD; William听Boisseau,听MD; Hesham E.听Masoud,听MD; Carlos Ynigo听Lopez,听MD; Ameena听Rana,听MD; Samer Abdul听Kareem,听MD; Anvitha听Sathya; Piers听Klein; Mohammad W.听Kassem,听MD, MBA; Peter A.听Ringleb,听MD; Charlotte听Cordonnier,听MD, PhD; Jan听Gralla,听MD; Urs听Fischer,听MD, MSc; Patrik听Michel,听MD; Tudor G.听Jovin,听MD; Jean听Raymond,听MD; Osama O.听Zaidat,听MD, MS; Raul G.听Nogueira,听MD
    Abstract Full Text
    open access is active quiz
    榴莲视频 Neurol. 2021; 79(1):22-31. 10.1001/jamaneurol.2021.4082

    This cohort study compares the clinical outcomes of patients with stroke who presented 6 to 24 hours after symptom onset and were selected for mechanical thrombectomy by noncontrast computed tomography vs those selected by computed tomography perfusion or magnetic resonance imaging.

  • 榴莲视频 Neurology Original Investigation
    February 22, 2021

    Thrombectomy for Primary Distal Posterior Cerebral Artery Occlusion Stroke: The TOPMOST Study

    Lukas听Meyer,听MD; Christian Paul听Stracke,听MD; No毛l听Jungi,听MD; Marta听Wallocha,听MD; Gabriel听Broocks,听MD; Peter B.听Sporns,听PD, MD, MHBA; Christian听Maegerlein,听MD; Franziska听Dorn,听MD; Hanna听Zimmermann,听MD; Weis听Naziri,听MD; Nuran听Abdullayev,听MD; Christoph听Kabbasch,听MD; Daniel听Behme,听MD; Ala听Jamous,听MD; Volker听Maus,听MD; Sebastian听Fischer,听MD; Markus听M枚hlenbruch,听MD; Charlotte Sabine听Weyland,听MD; S枚nke听Langner,听MD; Dan听Meila,听MD; Milena听Miszczuk,听MD; Eberhard听Siebert,听MD; Stephan听Lowens,听MD; Lars Udo听Krause,听MD; Leonard L. L.听Yeo,听MBBS; Benjamin Yong-Qiang听Tan,听MD, PhD; Gopinathan听Anil,听MD; Benjamin听Gory,听MD, PhD; Jorge听Galv谩n,听MD; Miguel Sch眉ller听Arteaga,听MD; Pedro听Navia,听MD; Eytan听Raz,听MD; Maksim听Shapiro,听MD; Fabian听Arnberg,听MD, PhD; Kamil听Zele艌谩k,听MD, PhD; Mario听Martinez-Galdamez,听MD; Urs听Fischer,听MD; Andreas听Kastrup,听MD; Christian听Roth,听MD; Panagiotis听Papanagiotou,听MD; Andr茅听Kemmling,听MD; Jan听Gralla,听MD; Marios-Nikos听Psychogios,听MD; Tommy听Andersson,听MD; Rene听Chapot,听MD; Jens听Fiehler,听MD; Johannes听Kaesmacher,听MD; Uta听Hanning,听MD
    Abstract Full Text
    free access
    榴莲视频 Neurol. 2021; 78(4):434-444. 10.1001/jamaneurol.2021.0001

    This case-control study analyzes the clinical, functional, and safety outcomes associated with endovascular therapy for patients with posterior circulation distal, medium vessel occlusion.

  • 榴莲视频 Neurology Original Investigation
    December 9, 2019

    Safety and Efficacy of Intra-arterial Urokinase After Failed, Unsuccessful, or Incomplete Mechanical Thrombectomy in Anterior Circulation Large-Vessel Occlusion Stroke

    Johannes听Kaesmacher,听MD; Sebastian听Bellwald,听MD; Tomas听Dobrocky,听MD; Thomas R.听Meinel,听MD; Eike I.听Piechowiak,听MD; Martina听Goeldlin,听MD; Christoph C.听Kurmann,听MD; Mirjam R.听Heldner,听MD; Simon听Jung,听MD; Pasquale听Mordasini,听MD; Marcel听Arnold,听MD; Pascal J.听Mosimann,听MD; Gerhard听Schroth,听MD; Heinrich P.听Mattle,听MD; Jan听Gralla,听MD, MSc; Urs听Fischer,听MD, MSc
    Abstract Full Text
    free access
    榴莲视频 Neurol. 2019; 77(3):318-326. 10.1001/jamaneurol.2019.4192

    This cohort study assesses whether administration of intra-arterial urokinase is safe and improves reperfusion among patients who have undergone failed or incomplete mechanical thrombectomy.