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This narrative review, the second of 2 parts about a new approach to the diagnosis and treatment of psychiatric disorders that is based on dynamical systems theory, describes the implications of evidence for the practical applicability of this theory and its quantitative tools.

This narrative review describes a new approach to the diagnosis and treatment of psychiatric disorders that is based on dynamical systems theory, which addresses the concepts of tipping points, cycles, and chaos in complex systems.

This Viewpoint discusses whether psychiatric disorders are diseases of the brain.

This population register–based study examines data for offspring born in Sweden from 1960 to 1995 to evaluate the sources of parent-offspring transmission of OCD and its familial cross-generational association with more typical anxiety disorders.

This cohort study assesses the interrelationships of family genetic risk score with diagnostic stability or diagnostic change in major depression, bipolar disorder, other nonaffective psychosis, and schizophrenia in a Swedish national sample.

This cohort study examines data from Swedish population registries to determine the relationship between genetic risk factors for major depression and bipolar disorder.

This Viewpoint seeks to examine current psychiatric nosology through the lens of modern philosophy of science.

This genetic association study investigates the genetics of depression across multiple data sets of individuals of East Asian and European descent living in different countries and within different nongenetic cultural contexts.

This national cohort study assesses whether family genetic risk scores, calculated for the entire Swedish population, can elucidate the genetic association between major affective and psychotic disorders and clarify the effect of genetic risk on important clinical features of disease.

This Viewpoint discusses the importance of in-depth phenotyping, biological assessment, and causal inferences in studying the etiology of psychiatric disorders.

This Viewpoint reviews reports that relied on 4 genetic methods capable of addressing the nature of the cannabis-schizophrenia association.

This narrative review chronicles the development by Kraepelin of the concept and clinical forms of dementia praecox.

This cohort study examines the transmission of bipolar disorder to bipolar disorder, schizophrenia, and major depression across family generations.

This narrative review chronicles the evolution of the concept of melancholia to depression over 100 years from 1780 to 1880.

This review examines approaches to causal inference in psychiatric epidemiology.

This Special Communication describes the history of the psychiatric field to discover a single cause or many causes of specific psychiatric disorders and discusses whether doing so will legitimate the discipline of psychiatry.

This article describes the development of categories of mental illness by Emil Kraepelin in the second through sixth editions of his textbook Psychiatrie: Ein Lehrbuch für Studierende und Ärzte.

To clarify the nature of the association between adolescent academic achievement and drug abuse into middle adulthood, this study uses 2 methods for assessing associations in observational studies, instrumental variable (with month of birth as the instrument) and co-relative analyses, and long-term follow-up to assess data from 934 462 individuals born in Sweden between 1971 and 1982.

This population-based study examines the association, among first marriages, of alcohol use disorder in one person with the risk of registration in his or her spouse, and changes in the risk for the disorder among those with multiple marriages as they transition from a spouse with the disorder to one without or vice versa.