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Ƶ Neurology
Original Investigation
February 8, 2024
AmrouSarraj,MD; Michael D.Hill,MD; M. ShazamHussain,MD; Michael G.Abraham,MD; SantiagoOrtega-Gutierrez,MD; MichaelChen,MD; Scott E.Kasner,MD; LeonidChurilov,PhD; Deep K.Pujara,MBBS; HannahJohns,PhD; SpirosBlackburn,MD; SophiaSundararajan,MD; Yin C.Hu,MD; Nabeel A.Herial,MD; Ronald F.Budzik,MD; William J.Hicks,MD; Juan F.Arenillas,MD, PhD; Jenny P.Tsai,MD; OsmanKozak,MD; Dennis J.Cordato,PhD; Ricardo A.Hanel,MD; Teddy Y.Wu,PhD; Pere CardonaPortela,MD; Chirag D.Gandhi,MD; FawazAl-Mufti,MD; LaithMaali,MD; DanielGibson,MD; NataliaPérez de la Ossa,MD, PhD; Joanna D.Schaafsma,MD; JordiBlasco,MD, PhD; NavdeepSangha,MD; StevenWarach,MD; Timothy J.Kleinig,PhD; FarisShaker,MBChB; Clark W.Sitton,MD; ThanhNguyen,MD; Johanna T.Fifi,MD; PascalJabbour,MD; AnthonyFurlan,MD; Maarten G.Lansberg,MD; GeorgiosTsivgoulis,MD; CathySila,MD; NicholasBambakidis,MD; StephenDavis,MD; LawrenceWechsler,MD; Greg W.Albers,MD; James C.Grotta,MD; MarcRibo,MD; Bruce C.Campbell,MD; Ameer E.Hassan,MD; SELECT2 Investigators; SELECT2 Collaborators
Ƶ Neurol. 2024; 81(4):327-335. 10.1001/jamaneurol.2024.0206
This prespecified analysis of the SELECT2 trial assesses endovascular thrombectomy treatment effects in transferred vs directly presenting patients and evaluates the association between transfer times and neuroimaging changes with endovascular thrombectomy clinical outcomes.
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JAMA
Original Investigation
February 7, 2024
AmrouSarraj,MD; Ameer E.Hassan,DO; Michael G.Abraham,MD; SantiagoOrtega-Gutierrez,MD; Scott E.Kasner,MD; Muhammad ShazamHussain,MD; MichaelChen,MD; LeonidChurilov,PhD; HannahJohns,PhD; Clark W.Sitton,MD; VignanYogendrakumar,MD; Felix C.Ng,PhD; Deep K.Pujara,MBBS; SpirosBlackburn,MD; SophiaSundararajan,MD; Yin C.Hu,MD; Nabeel A.Herial,MD; Juan F.Arenillas,MD, PhD; Jenny P.Tsai,MD; Ronald F.Budzik,MD; William J.Hicks,MD; OsmanKozak,MD; BernardYan,MBBS; Dennis J.Cordato,PhD; Nathan W.Manning,MBBS; Mark W.Parsons,PhD; AndrewCheung,MBBS; Ricardo A.Hanel,MD; Amin N.Aghaebrahim,MD; Teddy Y.Wu,PhD; Pere CardonaPortela,MD; Chirag D.Gandhi,MD; FawazAl-Mufti,MD; NataliaPérez de la Ossa,MD, PhD; Joanna D.Schaafsma,MD, PhD; JordiBlasco,MD, PhD; NavdeepSangha,MD; StevenWarach,MD; Timothy J.Kleinig,PhD; FarisShaker,MBChB; FaisalAl Shaibi,MD; GaborToth,MD; Mohammad A.Abdulrazzak,MD; GaganSharma,MS; AbhishekRay,MD; JeffreySunshine,MD, PhD; AmandaOpaskar,MD; Kelsey R.Duncan,MD; WeiXiong,MD; Edgar A.Samaniego,MD; LaithMaali,MD; Colleen G.Lechtenberg,MD; ArturoRenú,MD; NiravVora,MD; ThanhNguyen,MD; Johanna T.Fifi,MD; Stavropoula I.Tjoumakaris,MD; PascalJabbour,MD; GeorgiosTsivgoulis,MD; Vitor MendesPereira,MD; Maarten G.Lansberg,MD; MichaelDeGeorgia,MD; Cathy A.Sila,MD; NicholasBambakidis,MD; Michael D.Hill,MD; Stephen M.Davis,MD; LawrenceWechsler,MD; James C.Grotta,MD; MarcRibo,MD; Greg W.Albers,MD; Bruce C.Campbell,PhD; SELECT2 Investigators
JAMA. 2024; 331(9):750-763. 10.1001/jama.2024.0572
This exploratory analysis of the SELECT2 trial assesses the relationship between imaging estimates of irreversibly injured brain (core) and at-risk regions (mismatch) and the association of mismatch with clinical outcomes and endovascular treatment effect in adult patients with acute ischemic stroke due to occlusion of the internal carotid or middle cerebral artery and large ischemic core in 31 global centers between October 2019 and September 2022.
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Ƶ Neurology
Original Investigation
August 21, 2023
AnnaRamos-Pachón,MD; DavidRodríguez-Luna,MD, PhD; JoanMartí-Fàbregas,MD, PhD; MònicaMillán,MD, PhD; AlejandroBustamante,MD, PhD; MarinaMartínez-Sánchez,MD; JoaquínSerena,MD, PhD; MikelTerceño,MD, PhD; CarlaVera-Cáceres,MD; PolCamps-Renom,MD, PhD; LuisPrats-Sánchez,MD, PhD; NoeliaRodríguez-Villatoro,MD, PhD; PereCardona-Portela,MD; XabierUrra,MD, PhD; SilviaSolà,MD; Mariadel Mar Escudero,RN; MercèSalvat-Plana,RN; Marc龱ó,MD, PhD; SòniaAbilleira,MD, PhD; NataliaPérez de la Ossa,MD, PhD; YolandaSilva,MD, PhD; RACECAT Trial Investigators
Ƶ Neurol. 2023; 80(10):1028-1036. 10.1001/jamaneurol.2023.2754
This prespecified secondary analysis of a randomized clinical trial conducted in Catalonia, Spain, assesses whether direct transport to an endovascular treatment–capable stroke center vs to the nearest local stroke center benefits patients experiencing intracerebral hemorrhage.
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Ƶ Neurology
Original Investigation
June 20, 2023
MacarenaHernández-Jiménez,PhD; FranciscoAbad-Santos,MD; IanCotgreave,PhD; JaimeGallego,MD; BerndJilma,MD; AlanFlores,MD; Tudor G.Jovin,MD; JoséVivancos,MD; MaríaHernández-Pérez,MD; Carlos A.Molina,MD; JoanMontaner,MD; JoaquínCasariego,MD; MadsDalsgaard,MD; David S.Liebeskind,MD; ErikCobo,MD; MarCastellanos,MD; Pere CardonaPortela,MD; JaimeMasjuán,MD; FranciscoMoniche,MD; José IgnacioTembl,MD; MikelTerceño Izaga,MD; Juan F.Arenillas,MD; PatriciaCalleja,MD; Jean MarcOlivot,MD; LionelCalviere,MD; HildeHenon,MD; MikaelMazighi,MD; DavidPiñeiro,PhD; MarcoPugliese,MD; Victor M.González,PhD; Maria AngelesMoro,PhD; AlvaroGarcia-Tornel,MD; IgnacioLizasoain,PhD; MarcRibo,MD
Ƶ Neurol. 2023; 80(8):779-788. 10.1001/jamaneurol.2023.1660
This randomized clinical trial investigates the safety and efficacy of ApTOLL as a neuroprotectant drug for patients with ischemic stroke when given in combination with endovascular treatment.
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Ƶ Network Open
Original Investigation
Neurology
March 1, 2023
MudassirFarooqui,MD, MPH; Osama O.Zaidat,MD, MS; Ameer E.Hassan,DO; DarkoQuispe-Orozco,MD; NilsPetersen,MD; Afshin A.Divani,PhD; MarcRibo,MD, PhD; MichaelAbraham,MD; JohannaFifi,MD; Waldo R.Guerrero,MD; Amer M.Malik,MD, MBA; James E.Siegler,MD; Thanh N.Nguyen,MD; SunilSheth,MD; Albert J.Yoo,MD, PhD; GuillermoLinares,MD; NazliJanjua,MD; MilagrosGalecio-Castillo,MD; Wondewossen G.Tekle,MD; Victor M.Ringheanu,BA; MarionOliver,MD; GianaDawod,MD; JessicaKobsa,BA; AyushPrasad,BA; AsadIkram,MD; EugeneLin,MD; KristineBelow,BA; Cynthia B.Zevallos,MD; Marta OlivéGadea,MD; AbidQureshi,MD; AndresDajles,MS; StavrosMatsoukas,MD; AmeenaRana,MD; MohamadAbdalkader,MD; SergioSalazar-Marioni,MD; JazbaSoomro,MD; WestonGordon,MD; JuanVivanco-Suarez,MD; CharoskhonTurabova,MD; MaximMokin,MD; Dileep R.Yavagal,MD; Mouhammad A.Jumaa,MD; SantiagoOrtega-Gutierrez,MD, MSc
open access
Ƶ Netw Open. 2023; 6(3):e230736. 10.1001/jamanetworkopen.2023.0736
This cross-sectional study evaluates the clinical and technical outcomes of carotid artery stenting vs no stenting during mechanical thrombectomy in patients with acute large vessel occlusion strokes and concomitant tandem lesions.
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Ƶ Neurology
Original Investigation
December 27, 2022
AmrouSarraj,MD; Timothy J.Kleinig,MBBS(Hons), PhD; Ameer E.Hassan,DO; Pere CardonaPortela,MD; SantiagoOrtega-Gutierrez,MD; Michael G.Abraham,MD; Nathan W.Manning,MD; James E.Siegler,MD; NitinGoyal,MD; LaithMaali,MD; SpirosBlackburn,MD; Teddy Y.Wu,MBChB; JordiBlasco,MD; ArturuRenú,MD; Navdeep S.Sangha,MD; Juan F.Arenillas,MD; Margy E.McCullough-Hicks,MD; AdamWallace,MD; DanielGibson,MD; Deep K.Pujara,MBBS; FarisShaker,MBChB; Mercedesde Lera Alfonso,MD; MartaOlivé-Gadea,MD; MudassirFarooqui,MD; Juan S.Vivanco Suarez,MD; ZacharyIezzi,BS; JaneKhalife,MD; Colleen G.Lechtenberg,MD; Syed K.Qadri,MD; Rami B.Moussa,BS; Mohammad A.Abdulrazzak,MD; Tareq S.Almaghrabi,MBBS; OsmanMir,MD; JamesBeharry,MBChB; BalajiKrishnaiah,MD; MeganMiller,BS; NajwaKhalil,MBBS; Gagan J.Sharma,MS; Aristeidis H.Katsanos,MD; AliFadhil,MD; Kelsey R.Duncan,MD; YinHu,MD; Sheryl B.Martin-Schild,MD; Georgios K.Tsivgoulis,MD; DennisCordato,MBBS; AnthonyFurlan,MD; LeonidChurilov,PhD; Peter J.Mitchell,MD; Adam S.Arthur,MD; Mark W.Parsons,MD; James C.Grotta,MD; Clark W.Sitton,MD; MarcRibo,MD; Gregory W.Albers,MD; Bruce C. V.Campbell,MBBS, PhD
free access
has multimedia
Ƶ Neurol. 2022; 80(2):172-182. 10.1001/jamaneurol.2022.4714
This cohort study analyzes data for patients who were treated beyond 24 hours after they were last known well to determine functional and safety outcomes for endovascular thrombectomy vs best medical management.
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JAMA
Original Investigation
May 5, 2022
NataliaPérez de la Ossa,PhD; SòniaAbilleira,PhD; Tudor G.Jovin,PhD; ÁlvaroGarcía-Tornel,PhD; XavierJimenez,PhD; XabierUrra,PhD; PereCardona,MD; DoloresCocho,PhD; FranciscoPurroy,PhD; JoaquinSerena,PhD; LuisSan Román Manzanera,PhD; Rosa MariaVivanco-Hidalgo,PhD; MercèSalvat-Plana,RN; AngelChamorro,PhD; MiquelGallofré,PhD; Carlos A.Molina,PhD; ErikCobo,PhD; AntoniDavalos,PhD; MarcRibo,PhD; RACECAT Trial Investigators
free access
JAMA. 2022; 327(18):1782-1794. 10.1001/jama.2022.4404
This randomized trial assesses the effect of transportation to a local stroke center vs directly to a thrombectomy-capable referral center on 90-day disability among patients with acute large-vessel occlusion stroke attended by emergency medical services in areas where the closest local stroke center was not capable of performing thrombectomy.
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Ƶ Neurology
Comment & Response
February 7, 2022
MarcRibo,MD, PhD; ManuelRequena,MD, PhD
Ƶ Neurol. 2022; 79(3):312-312. 10.1001/jamaneurol.2021.5346
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Ƶ Neurology
Original Investigation
November 8, 2021
Thanh N.Nguyen,MD; MohamadAbdalkader,MD; SimonNagel,MD; Muhammad M.Qureshi,MPH; MarcRibo,MD, PhD; FrancoisCaparros,MD; Diogo C.Haussen,MD; Mahmoud H.Mohammaden,MD, MSc; Sunil A.Sheth,MD; SantiagoOrtega-Gutierrez,MD, MSc; James E.Siegler,MD; SyedZaidi,MD; MartaOlive-Gadea,MD; HildeHenon,MD, PhD; Markus A.Möhlenbruch,MD; Alicia C.Castonguay,PhD; StefaniaNannoni,MD; JohannesKaesmacher,MD; Ajit S.Puri,MD; FatihSeker,MD; MudassirFarooqui,MD, MPH; SergioSalazar-Marioni,MD; Anna L.Kuhn,MD; ArtemKaliaev,MD; BehzadFarzin,MD; WilliamBoisseau,MD; Hesham E.Masoud,MD; Carlos YnigoLopez,MD; AmeenaRana,MD; Samer AbdulKareem,MD; AnvithaSathya; PiersKlein; Mohammad W.Kassem,MD, MBA; Peter A.Ringleb,MD; CharlotteCordonnier,MD, PhD; JanGralla,MD; UrsFischer,MD, MSc; PatrikMichel,MD; Tudor G.Jovin,MD; JeanRaymond,MD; Osama O.Zaidat,MD, MS; Raul G.Nogueira,MD
open access
is active quiz
Ƶ Neurol. 2021; 79(1):22-31. 10.1001/jamaneurol.2021.4082
This cohort study compares the clinical outcomes of patients with stroke who presented 6 to 24 hours after symptom onset and were selected for mechanical thrombectomy by noncontrast computed tomography vs those selected by computed tomography perfusion or magnetic resonance imaging.
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Ƶ Neurology
Original Investigation
August 2, 2021
ManuelRequena,PhD; MartaOlivé-Gadea,MD; MarianMuchada,PhD; DavidHernández,MD; MartaRubiera,PhD; SandraBoned,PhD; CarlosPiñana,MD; MatíasDeck,MD; ÁlvaroGarcía-Tornel,MD; HumbertoDíaz-Silva,MD; NoeliaRodriguez-Villatoro,PhD; JesúsJuega,MD; DavidRodriguez-Luna,PhD; JorgePagola,PhD; CarlosMolina,PhD; AlejandroTomasello,MD; MarcRibo,MD, PhD
free access
Ƶ Neurol. 2021; 78(9):1099-1107. 10.1001/jamaneurol.2021.2385
This randomized clinical trial assesses whether direct transfer to the angiography suite improves clinical outcomes compared with usual imaging workflow among patients within 6 hours from onset of symptoms for large vessel occlusion ischemic stroke.
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Ƶ Neurology
Original Investigation
July 26, 2021
Gregory W.Albers,MD; Maarten G.Lansberg,MD, PhD; ScottBrown,PhD; Ashutosh P.Jadhav,MD, PhD; Diogo C.Haussen,MD; Sheila O.Martins,MD, PhD; Leticia C.Rebello,MD; Andrew M.Demchuk,MD; MayankGoyal,MD, PhD; MarcRibo,MD; Aquilla S.Turk,DO; David S.Liebeskind,MD; Jeremy J.Heit,MD, PhD; Michael P.Marks,MD; Tudor G.Jovin,MD; Raul G.Nogueira,MD; AURORA Investigators
free access
Ƶ Neurol. 2021; 78(9):1064-1071. 10.1001/jamaneurol.2021.2319
This pooled analysis uses data from 6 randomized clinical trials to assess the potential benefits of endovascular thrombectomy among patients with ischemic stroke based on 3 baseline imaging profiles.
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Ƶ Neurology
Original Investigation
June 14, 2021
AmrouSarraj,MD; NitinGoyal,MD; MichaelChen,MD; James C.Grotta,MD; SpirosBlackburn,MD; ManuelRequena,MD; HarisKamal,MD; Michael G.Abraham,MD; LucasElijovich,MD; MarkDannenbaum,MD; OsmanMir,MD; Wondwossen G.Tekle,MD; DeepPujara,MBBS, MPH; FarisShaker,MBChB; ChunyanCai,PhD; LaithMaali,MD; YazanRadaideh,MD; Sujan TeegalaReddy,MD; Kaushik NiranjanParsha,MD; BaderAlenzi,MD; Mohammad AmmarAbdulrazzak,MD; JonathanGreco,DO; DanielHoit,MD; Sheryl B.Martin-Schild,MD; SarahSong,MD, MPH; ClarkSitton,MD; Georgios K.Tsivgoulis,MD; Andrei V.Alexandrov,MD; Adam S.Arthur,MD, MPH; Arthur L.Day,MD; Ameer E.Hassan,DO; MarcRibo,MD
free access
is active quiz
Ƶ Neurol. 2021; 78(8):916-926. 10.1001/jamaneurol.2021.1707
This pooled cohort study evaluates the functional and safety outcomes of the direct to angiography vs repeated imaging approaches in the different treatment windows and on-call vs regular hours in patients with large vessel occlusion undergoing transfer for endovascular thrombectomy.
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Ƶ Neurology
Original Investigation
January 22, 2019
RomainBourcier,MD; MayankGoyal,MD; David S.Liebeskind,MD; Keith W.Muir,MD; HubertDesal,MD; Adnan H.Siddiqui,MD, PhD; Diederik W. J.Dippel,MD; Charles B.Majoie,MD; Wim H.van Zwam,MD; Tudor G.Jovin,MD; Elad I.Levy,MD, MBA; Peter J.Mitchell,MD; Olvert A.Berkhemer,MD; Stephen M.Davis,MD; ImadDerraz,MD; Geoffrey A.Donnan,MD; Andrew M.Demchuk,MD; Robert J.van Oostenbrugge,MD; MichaelKelly,MD; Yvo B.Roos,MD, PhD; RezaJahan,MD; Aadvan der Lugt,MD; MariekeSprengers,MD; StephaneVelasco,MD; Geert J.Lycklama à Nijeholt,MD; WagihBen Hassen,MD; PaulBurns,MB, BCh; ScottBrown,MD; EmmanuelChabert,MD; TimoKrings,MD; HanaChoe,MD; ChristianWeimar,MD; Bruce C. V.Campbell,MD; Gary A.Ford,MD; MarcRibo,MD; PhilWhite,MD; Geoffrey C.Cloud,MD; LuisSan Roman,MD; AntoniDavalos,MD, PhD; OlivierNaggara,MD; Michael D.Hill,MD; SergeBracard,MD; for the HERMES Trialists Collaboration
free access
Ƶ Neurol. 2019; 76(4):405-411. 10.1001/jamaneurol.2018.4510
This meta-analysis of individual patient data from 7 randomized clinical trials analyzes the rate of reperfusion after endovascular thrombectomy started at different intervals after symptom onset in patients with acute ischemic stroke.
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Ƶ Neurology
Original Investigation
January 7, 2019
Anna M. M.Boers,PhD; Ivo G. H.Jansen,MD, PhD; ScottBrown,PhD; Hester F.Lingsma,PhD; Ludo F. M.Beenen,MD; Thomas G.Devlin,MD, PhD; Luis SanRomán,MD, PhD; Ji-HoeHeo,MD, PhD; Marc龱ó,MD; Mohammed A.Almekhlafi,MD, FRCPC; David S.Liebeskind,MD; JeanneTeitelbaum,MD; PatriciaCuadras,MD; Richarddu Mesnil de Rochemont,MD, PhD; MarineBeaumont,PhD; Martin M.Brown,MD, FRCP; Albert J.Yoo,MD, PhD; Geoffrey A.Donnan,MD; Jean LouisMas,MD; CatherineOppenheim,PhD; Richard J.Dowling,MBBS; ThierryMoulin,MD, PhD; NellyAgrinier,MD, PhD; Demetrius K.Lopes,MD; LucíaAja Rodríguez,MD; Kars C. J.Compagne,MSc; Fahad S.Al-Ajlan,MD; JeremyMadigan,MB ChB; Gregory W.Albers,MD; SebastienSoize,MD; JordiBlasco,MD, PhD; Stephen M.Davis,MD; Raul G.Nogueira,MD; AntoniDávalos,MD, PhD; Bijoy K.Menon,MD; Aadvan der Lugt,MD, PhD; Keith W.Muir,MD; Yvo B. W. E. M.Roos,MD, PhD; PhilWhite,MD, PhD; Peter J.Mitchell,MD; Andrew M.Demchuk,MD, FRCPC; Wim H.van Zwam,MD; Tudor G.Jovin,MD; Robert J.van Oostenbrugge,MD, PhD; Diederik W. J.Dippel,MD, PhD; Bruce C. V.Campbell,PhD, FRACP; FrancisGuillemin,MD, PhD; SergeBracard,PhD; Michael D.Hill,MD; MayankGoyal,MD, FRCPC; Henk A.Marquering,PhD; Charles B. L. M.Majoie,MD, PhD
free access
Ƶ Neurol. 2019; 76(2):194-202. 10.1001/jamaneurol.2018.3661
This pooled data analysis of 7 randomized clinical trials of thrombectomy for acute ischemic stroke examines whether follow-up infarct volume mediates the relationship between endovascular therapy and functional outcome in patients with acute ischemic stroke.