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  • Endovascular Thrombectomy Treatment Effect in Direct vs Transferred Patients With Large Ischemic Strokes: A Prespecified Analysis of the SELECT2 Trial

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    Ƶ Neurol. 2024; 81(4):327-335. 10.1001/jamaneurol.2024.0206

    This prespecified analysis of the SELECT2 trial assesses endovascular thrombectomy treatment effects in transferred vs directly presenting patients and evaluates the association between transfer times and neuroimaging changes with endovascular thrombectomy clinical outcomes.

  • Endovascular Thrombectomy for Large Ischemic Stroke Across Ischemic Injury and Penumbra Profiles

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    JAMA. 2024; 331(9):750-763. 10.1001/jama.2024.0572

    This exploratory analysis of the SELECT2 trial assesses the relationship between imaging estimates of irreversibly injured brain (core) and at-risk regions (mismatch) and the association of mismatch with clinical outcomes and endovascular treatment effect in adult patients with acute ischemic stroke due to occlusion of the internal carotid or middle cerebral artery and large ischemic core in 31 global centers between October 2019 and September 2022.

  • Effect of Bypassing the Closest Stroke Center in Patients with Intracerebral Hemorrhage: A Secondary Analysis of the RACECAT Randomized Clinical Trial

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    Ƶ Neurol. 2023; 80(10):1028-1036. 10.1001/jamaneurol.2023.2754

    This prespecified secondary analysis of a randomized clinical trial conducted in Catalonia, Spain, assesses whether direct transport to an endovascular treatment–capable stroke center vs to the nearest local stroke center benefits patients experiencing intracerebral hemorrhage.

  • Safety and Efficacy of ApTOLL in Patients With Ischemic Stroke Undergoing Endovascular Treatment: A Phase 1/2 Randomized Clinical Trial

    Abstract Full Text
    Ƶ Neurol. 2023; 80(8):779-788. 10.1001/jamaneurol.2023.1660

    This randomized clinical trial investigates the safety and efficacy of ApTOLL as a neuroprotectant drug for patients with ischemic stroke when given in combination with endovascular treatment.

  • Functional and Safety Outcomes of Carotid Artery Stenting and Mechanical Thrombectomy for Large Vessel Occlusion Ischemic Stroke With Tandem Lesions

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    open access
    Ƶ Netw Open. 2023; 6(3):e230736. 10.1001/jamanetworkopen.2023.0736

    This cross-sectional study evaluates the clinical and technical outcomes of carotid artery stenting vs no stenting during mechanical thrombectomy in patients with acute large vessel occlusion strokes and concomitant tandem lesions.

  • Association of Endovascular Thrombectomy vs Medical Management With Functional and Safety Outcomes in Patients Treated Beyond 24 Hours of Last Known Well: The SELECT Late Study

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    Ƶ Neurol. 2022; 80(2):172-182. 10.1001/jamaneurol.2022.4714

    This cohort study analyzes data for patients who were treated beyond 24 hours after they were last known well to determine functional and safety outcomes for endovascular thrombectomy vs best medical management.

  • Effect of Direct Transportation to Thrombectomy-Capable Center vs Local Stroke Center on Neurological Outcomes in Patients With Suspected Large-Vessel Occlusion Stroke in Nonurban Areas: The RACECAT Randomized Clinical Trial

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    JAMA. 2022; 327(18):1782-1794. 10.1001/jama.2022.4404

    This randomized trial assesses the effect of transportation to a local stroke center vs directly to a thrombectomy-capable referral center on 90-day disability among patients with acute large-vessel occlusion stroke attended by emergency medical services in areas where the closest local stroke center was not capable of performing thrombectomy.

  • Disentangling Workflow Paradigms and Treatment Decision-Making in Acute Ischemic Stroke—Reply

    Abstract Full Text
    Ƶ Neurol. 2022; 79(3):312-312. 10.1001/jamaneurol.2021.5346
  • Noncontrast Computed Tomography vs Computed Tomography Perfusion or Magnetic Resonance Imaging Selection in Late Presentation of Stroke With Large-Vessel Occlusion

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    Ƶ Neurol. 2021; 79(1):22-31. 10.1001/jamaneurol.2021.4082

    This cohort study compares the clinical outcomes of patients with stroke who presented 6 to 24 hours after symptom onset and were selected for mechanical thrombectomy by noncontrast computed tomography vs those selected by computed tomography perfusion or magnetic resonance imaging.

  • Direct to Angiography Suite Without Stopping for Computed Tomography Imaging for Patients With Acute Stroke: A Randomized Clinical Trial

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    Ƶ Neurol. 2021; 78(9):1099-1107. 10.1001/jamaneurol.2021.2385

    This randomized clinical trial assesses whether direct transfer to the angiography suite improves clinical outcomes compared with usual imaging workflow among patients within 6 hours from onset of symptoms for large vessel occlusion ischemic stroke.

  • Assessment of Optimal Patient Selection for Endovascular Thrombectomy Beyond 6 Hours After Symptom Onset: A Pooled Analysis of the AURORA Database

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    Ƶ Neurol. 2021; 78(9):1064-1071. 10.1001/jamaneurol.2021.2319

    This pooled analysis uses data from 6 randomized clinical trials to assess the potential benefits of endovascular thrombectomy among patients with ischemic stroke based on 3 baseline imaging profiles.

  • Direct to Angiography vs Repeated Imaging Approaches in Transferred Patients Undergoing Endovascular Thrombectomy

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    Ƶ Neurol. 2021; 78(8):916-926. 10.1001/jamaneurol.2021.1707

    This pooled cohort study evaluates the functional and safety outcomes of the direct to angiography vs repeated imaging approaches in the different treatment windows and on-call vs regular hours in patients with large vessel occlusion undergoing transfer for endovascular thrombectomy.

  • Association of Time From Stroke Onset to Groin Puncture With Quality of Reperfusion After Mechanical Thrombectomy: A Meta-analysis of Individual Patient Data From 7 Randomized Clinical Trials

    Abstract Full Text
    free access
    Ƶ Neurol. 2019; 76(4):405-411. 10.1001/jamaneurol.2018.4510

    This meta-analysis of individual patient data from 7 randomized clinical trials analyzes the rate of reperfusion after endovascular thrombectomy started at different intervals after symptom onset in patients with acute ischemic stroke.

  • Mediation of the Relationship Between Endovascular Therapy and Functional Outcome by Follow-up Infarct Volume in Patients With Acute Ischemic Stroke

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    Ƶ Neurol. 2019; 76(2):194-202. 10.1001/jamaneurol.2018.3661

    This pooled data analysis of 7 randomized clinical trials of thrombectomy for acute ischemic stroke examines whether follow-up infarct volume mediates the relationship between endovascular therapy and functional outcome in patients with acute ischemic stroke.