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JAMA Cardiology
Original Investigation
February 21, 2024
Michael T.听Lu,听MD, MPH; Heather听Ribaudo,听PhD; Borek听Foldyna,听MD; Markella V.听Zanni,听MD; Thomas听Mayrhofer,听PhD; Julia听Karady,听MD, PhD; Jana听Taron,听MD; Kathleen V.听Fitch,听MSN; Sara听McCallum,听MPH; Tricia H.听Burdo,听PhD; Kayla听Paradis,听MBA; Sandeep S.听Hedgire,听MD; Nandini M.听Meyersohn,听MD; Christopher听DeFilippi,听MD; Carlos D.听Malvestutto,听MD, MPH; Audra听Sturniolo,听MS; Marissa听Diggs,听BA; Sue听Siminski,听MBA; Gerald S.听Bloomfield,听MD; Beverly听Alston-Smith,听MD; Patrice听Desvigne-Nickens,听MD; Edgar T.听Overton,听MD; Judith S.听Currier,听MD; Judith A.听Aberg,听MD; Carl J.听Fichtenbaum,听MD; Udo听Hoffmann,听MD, MPH; Pamela S.听Douglas,听MD; Steven K.听Grinspoon,听MD; REPRIEVE Trial Writing Group
open access
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JAMA Cardiol. 2024; 9(4):323-334. 10.1001/jamacardio.2023.5661
This substudy of a randomized clinical trial investigates the effects of pitavastatin on noncalcified coronary artery plaque using coronary computed tomography angiography and on inflammatory biomarkers as potential mechanisms for major adverse cardiovascular event prevention.
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JAMA
Original Investigation
January 17, 2023
Robert J.听Mentz,听MD; Kevin J.听Anstrom,听PhD; Eric L.听Eisenstein,听DBA; Shelly听Sapp,听MS; Stephen J.听Greene,听MD; Shelby听Morgan,听BSN; Jeffrey M.听Testani,听MD, MTR; Amanda H.听Harrington,听BSW; Vandana听Sachdev,听MD; Fassil听Ketema,听MSc; Dong-Yun听Kim,听PhD; Patrice听Desvigne-Nickens,听MD; Bertram听Pitt,听MD; Eric J.听Velazquez,听MD; TRANSFORM-HF Investigators
free access
JAMA. 2023; 329(3):214-223. 10.1001/jama.2022.23924
This clinical trial compares the efficacy of torsemide vs furosemide in decreasing the risk of death from any cause among patients hospitalized for heart failure (regardless of ejection fraction).
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JAMA Cardiology
Special Communication
December 7, 2022
Emelia J.听Benjamin,听MD, ScM; Kevin L.听Thomas,听MD; Alan S.听Go,听MD; Patrice听Desvigne-Nickens,听MD; Christine M.听Albert,听MD, MPH; Alvaro听Alonso,听MD, PhD; Alanna M.听Chamberlain,听PhD; Utibe R.听Essien,听MD, MPH; Inmaculada听Hernandez,听PharmD, PhD; Mellanie True听Hills,听BS; Kiarri N.听Kershaw,听PhD, MPH; Phillip D.听Levy,听MD, MPH; Jared W.听Magnani,听MD, MSc; Daniel D.听Matlock,听MD, MPH; Emily C.听O鈥橞rien,听PhD; Carlos J.听Rodriguez,听MD, MPH; Andrea M.听Russo,听MD; Elsayed Z.听Soliman,听MD, MS; Lawton S.听Cooper,听MD, MPH; Sana M.听Al-Khatib,听MD, MHS
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JAMA Cardiol. 2022; 8(2):182-191. 10.1001/jamacardio.2022.4091
This study summarizes discussions from a National Heart, Lung, and Blood Institute workshop about knowledge gaps and research opportunities in social determinants of health research that address the distinctive aspects of atrial fibrillation.
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JAMA Cardiology
Special Communication
March 23, 2022
Ersilia M.听DeFilippis,听MD; Melvin听Echols,听MD; Philip B.听Adamson,听MD, MSc; Wayne B.听Batchelor,听MD, MHS; Lauren B.听Cooper,听MD, MHS; Lawton S.听Cooper,听MD, MPH; Patrice听Desvigne-Nickens,听MD; Richard T.听George,听MD; Nasrien E.听Ibrahim,听MD; Mariell听Jessup,听MD; Dalane W.听Kitzman,听MD; Eric S.听Leifer,听PhD; Martin听Mendoza,听PhD; Ileana L.听Pi帽a,听MD, MPH; Mitchell听Psotka,听MD, PhD; Fortunato Fred听Senatore,听MD, PhD; Kenneth M.听Stein,听MD; John R.听Teerlink,听MD; Clyde W.听Yancy,听MD, MSc; JoAnn听Lindenfeld,听MD; Mona听Fiuzat,听PharmD; Christopher M.听O鈥機onnor,听MD; Orly听Vardeny,听PharmD, MS; Muthiah听Vaduganathan,听MD, MPH
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JAMA Cardiol. 2022; 7(5):540-548. 10.1001/jamacardio.2022.0161
This Special Communication outlines strategies for heart failure clinical trials to promote enrollment of participants from underrepresented racial and ethnic minority groups.
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JAMA Cardiology
Original Investigation
November 3, 2021
Douglas L.听Mann,听MD; Michael M.听Givertz,听MD; Justin M.听Vader,听MD; Randall C.听Starling,听MD, MPH; Palak听Shah,听MD, MS; Steven E.听McNulty,听MS; Kevin J.听Anstrom,听PhD; Kenneth B.听Margulies,听MD; Michael S.听Kiernan,听MD, MS; Claudius听Mahr,听DO; Divya听Gupta,听MD; Margaret M.听Redfield,听MD; Anuradha听Lala,听MD; Gregory D.听Lewis,听MD; Adam D.听DeVore,听MD, MHS; Patrice听Desvigne-Nickens,听MD; Adrian F.听Hernandez,听MD, MHS; Eugene听Braunwald,听MD; LIFE Investigators
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JAMA Cardiol. 2021; 7(1):17-25. 10.1001/jamacardio.2021.4567
This randomized clinical trial evaluates the use of sacubitril/valsartan therapy compared with valsartan alone in US patients with advanced chronic heart failure.
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JAMA
Original Investigation
November 6, 2018
Barry A.听Borlaug,听MD; Kevin J.听Anstrom,听PhD; Gregory D.听Lewis,听MD; Sanjiv J.听Shah,听MD; James A.听Levine,听MD, PhD; Gabe A.听Koepp,听MHA; Michael M.听Givertz,听MD; G. Michael听Felker,听MD; Martin M.听LeWinter,听MD; Douglas L.听Mann,听MD; Kenneth B.听Margulies,听MD; Andrew L.听Smith,听MD; W. H. Wilson听Tang,听MD; David J.听Whellan,听MD; Horng H.听Chen,听MB, BCh; Victor G.听Davila-Roman,听MD; Steven听McNulty,听MS; Patrice听Desvigne-Nickens,听MD; Adrian F.听Hernandez,听MD; Eugene听Braunwald,听MD; Margaret M.听Redfield,听MD; for the National Heart, Lung, and Blood Institute Heart Failure Clinical Research Network
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JAMA. 2018; 320(17):1764-1773. 10.1001/jama.2018.14852
This randomized clinical trial compares the effect of 4 weeks鈥� administration of inhaled, nebulized inorganic nitrite vs placebo on exercise capacity in patients with heart failure with preserved ejection fraction (HFpEF).
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榴莲视频 Network Open
Original Investigation
Cardiology
August 31, 2018
Patricia A.听Pellikka,听MD; Lilin听She,听PhD; Thomas A.听Holly,听MD; Grace听Lin,听MD; Padmini听Varadarajan,听MD; Ramdas G.听Pai,听MD; Robert O.听Bonow,听MD, MS; Gerald M.听Pohost,听MD; Julio A.听Panza,听MD; Daniel S.听Berman,听MD; David L.听Prior,听MBBS, PhD; Federico M.听Asch,听MD; Salvador听Borges-Neto,听MD; Paul听Grayburn,听MD; Hussein R.听Al-Khalidi,听PhD; Karol听Miszalski-Jamka,听MD, PhD; Patrice听Desvigne-Nickens,听MD; Kerry L.听Lee,听PhD; Eric J.听Velazquez,听MD; Jae K.听Oh,听MD
open access
online only
榴莲视频 Netw Open. 2018; 1(4):e181456. 10.1001/jamanetworkopen.2018.1456
This multicenter diagnostic study determines the intermodality variability of left ventricular ejection fraction (LVEF) measured by echocardiography, gated single-photon emission computed tomography (SPECT), and cardiovascular magnetic resonance (CMR) in patients with coronary artery disease and left ventricular dysfunction.
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JAMA Cardiology
Original Investigation
September 1, 2017
Javed听Butler,听MD, MPH; Kevin J.听Anstrom,听PhD; G. Michael听Felker,听MD, MHS; Michael M.听Givertz,听MD; Andreas P.听Kalogeropoulos,听MD, MPH, PhD; Marvin A.听Konstam,听MD; Douglas L.听Mann,听MD; Kenneth B.听Margulies,听MD; Steven E.听McNulty,听MS; Robert J.听Mentz,听MD; Margaret M.听Redfield,听MD; W. H. Wilson听Tang,听MD; David J.听Whellan,听MD, MHS; Monica听Shah,听MD, MHS; Patrice听Desvigne-Nickens,听MD; Adrian F.听Hernandez,听MD, MHS; Eugene听Braunwald,听MD; for the National Heart Lung and Blood Institute Heart Failure Clinical Research Network
free access
has multimedia
JAMA Cardiol. 2017; 2(9):950-958. 10.1001/jamacardio.2017.2198
This randomized clinical trial analyzes the effects of high-dose spironolactone vs usual care on N-terminal pro-B-type natriuretic peptide levels.
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JAMA
Original Investigation
August 22, 2017
G. Michael听Felker,听MD, MHS; Kevin J.听Anstrom,听PhD; Kirkwood F.听Adams,听MD; Justin A.听Ezekowitz,听MBBCh, MSc; Mona听Fiuzat,听PhD; Nancy听Houston-Miller,听RN, BSN; James L.听Januzzi听Jr,听MD; Daniel B.听Mark,听MD, MPH; Ileana L.听Pi帽a,听MD, MPH; Gayle听Passmore,听PMP; David J.听Whellan,听MD, MHS; Hongqiu听Yang,听PhD; Lawton S.听Cooper,听MD, MPH; Eric S.听Leifer,听PhD; Patrice听Desvigne-Nickens,听MD; Christopher M.听O鈥機onnor,听MD
free access
JAMA. 2017; 318(8):713-720. 10.1001/jama.2017.10565
This randomized clinical trial investigates whether reducing natriuretic peptide levels by titrating medication to reach the target of less than 1000 pg/mL in patients with heart failure and reduced ejection fraction improves clinical outcomes.
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JAMA
Original Investigation
May 16, 2017
Gregory D.听Lewis,听MD; Rajeev听Malhotra,听MD; Adrian F.听Hernandez,听MD, MHS; Steven E.听McNulty,听MS; Andrew听Smith,听MD; G. Michael听Felker,听MD, MHS; W. H. Wilson听Tang,听MD; Shane J.听LaRue,听MD; Margaret M.听Redfield,听MD; Marc J.听Semigran,听MD; Michael M.听Givertz,听MD; Peter听Van Buren,听MD; David听Whellan,听MD; Kevin J.听Anstrom,听PhD; Monica R.听Shah,听MD, MHS; Patrice听Desvigne-Nickens,听MD; Javed听Butler,听MD; Eugene听Braunwald,听MD; for the NHLBI Heart Failure Clinical Research Network
free access
JAMA. 2017; 317(19):1958-1966. 10.1001/jama.2017.5427
This randomized clinical trial investigates the efficacy of oral iron supplementation for improvement of exercise capacity in adult patients with heart failure with reduced left ventricular ejection fraction.
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JAMA
Brief Report
January 10, 2001
Judith S. Hochman, MD; Lynn A. Sleeper, ScD; Harvey D. White, DSc; Vladimir Dzavik, MD; S. Chiu Wong, MD; Venu Menon, MD; John G. Webb, MD; Richard Steingart, MD; Michael H. Picard, MD; Mark A. Menegus, MD; Jean Boland, MD; Timothy Sanborn, MD; Christopher E. Buller, MD; Sharada Modur, MS; Robert Forman, MD; Patrice Desvigne-Nickens, MD; Alice K. Jacobs, MD; James N. Slater, MD; Thierry H. LeJemtel, MD; for the SHOCK Investigators
free access
JAMA. 2001; 285(2):190-192. 10.1001/jama.285.2.190