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  • Late-Stage Cancer End Points to Speed Cancer Screening Clinical Trials—Not So Fast

    Abstract Full Text
    free access online first
    JAMA. 2024; 10.1001/jama.2024.5821
  • Clinical Trial Participation Among Older Adult Medicare Fee-for-Service Beneficiaries With Cancer

    Abstract Full Text
    free access
    JAMA Oncol. 2022; 8(12):1786-1792. 10.1001/jamaoncol.2022.5020

    This cohort study uses a novel population-based methodology to estimate the proportion of older adult Medicare Fee-for-Service beneficiaries with cancer who participate in interventional cancer clinical trials.

  • Validation of a Population-Based Data Source to Examine National Cancer Clinical Trial Participation

    Abstract Full Text
    open access
    Ƶ Netw Open. 2022; 5(3):e223687. 10.1001/jamanetworkopen.2022.3687

    This cohort study evaluates the validity linking fee-for-service Medicare claims and ClinicalTrials.gov through National Clinical Trial identifiers for patients with cancer enrolled in clinical trials.

  • Evaluation of Drug Trials in High-, Middle-, and Low-Income Countries and Local Commercial Availability of Newly Approved Drugs

    Abstract Full Text
    open access
    Ƶ Netw Open. 2021; 4(5):e217075. 10.1001/jamanetworkopen.2021.7075

    This cross-sectional study examines where drugs were tested for US Food and Drug Administration approval and determines how commonly and quickly these drugs received marketing approval in the countries where they were tested, both overall and by country income level and geographical region.

  • Assessment of Outcomes Associated With the Use of Newly Approved Oncology Drugs in Medicare Beneficiaries

    Abstract Full Text
    open access
    Ƶ Netw Open. 2021; 4(2):e210030. 10.1001/jamanetworkopen.2021.0030

    This cohort study evaluates the differences in survival, duration of therapy, and treatment patterns between clinical trial patients and older adults with Medicare receiving cancer drugs for metastatic solid cancers in usual practice.

  • Changes in Drug List Prices and Amounts Paid by Patients and Insurers

    Abstract Full Text
    open access
    Ƶ Netw Open. 2020; 3(12):e2028510. 10.1001/jamanetworkopen.2020.28510

    This cross-sectional study uses data from the IBM MarketScan Commercial Database to examine the association between increases in wholesale list prices of branded medications and amounts paid by patients and insurers for the same drugs.

  • Evaluation of Use of Shorter Radiation Regimens for Breast and Prostate Cancer in the US, 2015-2017

    Abstract Full Text
    open access
    Ƶ Netw Open. 2020; 3(7):e2010519. 10.1001/jamanetworkopen.2020.10519

    This cross-sectional study examines the usage rates and trends of shorter vs longer radiation regimens for breast cancer and prostate cancer treatments in the US.

  • Preventive Services Offered in Executive Physicals at Top-Ranked Hospitals

    Abstract Full Text
    free access
    JAMA. 2019; 322(11):1101-1103. 10.1001/jama.2019.10563

    This study describes health services offered by USNWR “best hospitals” in executive physical packages, daylong comprehensive evaluations offering testing and screening of wealthy individuals and corporate leaders.

  • Prescription Drugs—List Price, Net Price, and the Rebate Caught in the Middle

    Abstract Full Text
    JAMA. 2019; 321(16):1563-1564. 10.1001/jama.2019.2445

    In this Viewpoint, Peter Bach and colleague Stacie Dusetzina question the assumption underlying a 2019 proposed federal rule change to eliminate drug manufacturer rebates to pharmacy benefit managers (PBMs) as a way to decrease prescription drug prices, and they propose more extensive restructuring, including a cap on out-of-pocket spending for Medicare Part D beneficiaries, to better control drug costs and save patients money.

  • The 6 Functions of Health Insurance

    Abstract Full Text
    free access
    JAMA. 2019; 321(13):1242-1243. 10.1001/jama.2019.2320
  • The 6 Functions of Health Insurance

    Abstract Full Text
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    JAMA Forum Archive. 2019; A8(1) 10.1001/jamahealthforum.2019.0007
  • Expansion of the Medicare 340B Payment Program: Hospital Participation, Prescribing Patterns and Reimbursement, and Legal Challenges

    Abstract Full Text
    JAMA. 2018; 320(22):2311-2312. 10.1001/jama.2018.15667

    In this Viewpoint, the authors review Medicare & Medicaid Services 340B Payment program and recent rules to curtail expansion of drug discounts beyond serving poor patients.

  • Alternative State-Level Financing for Hepatitis C Treatment—The “Netflix Model”

    Abstract Full Text
    JAMA. 2018; 320(19):1977-1978. 10.1001/jama.2018.15782

    This Viewpoint discusses a “Netflix” subscription model of drug payment being investigated by Louisiana for hepatitis C (HCV) drugs, in which a statewide coalition of payers would pay subscription fees over a fixed number of years for HCV drugs to treat all state residents and for efforts by the manufacturers to enhance treatment rates through patient outreach.

  • Defining Value-Based Pricing of Drugs—Reply

    Abstract Full Text
    JAMA. 2018; 320(16):1710-1711. 10.1001/jama.2018.11820
  • Delays in the Publication of Important Clinical Trial Findings in Oncology

    Abstract Full Text
    free access online only
    JAMA Oncol. 2018; 4(7):e180264. 10.1001/jamaoncol.2018.0264

    This review of pharmaceutical company press releases assesses how long it takes for complete data from potentially practice-changing industry-sponsored clinical trials in oncology to be published following the availability of important results.

  • Surrogate Markers and the Association of Low-Dose CT Lung Cancer Screening With Mortality

    Abstract Full Text
    free access
    JAMA Oncol. 2018; 4(7):1006-1008. 10.1001/jamaoncol.2018.1263

    This study examines the reliability of predictive markers of CT screening for lung cancer and its association with patient outcomes, including mortality.

  • Value-Based Pricing for Drugs: Theme and Variations

    Abstract Full Text
    JAMA. 2018; 319(21):2165-2166. 10.1001/jama.2018.4871

    In this Viewpoint, Peter Bach and colleagues distinguish 5 pricing reform proposals implied by the concept of value-based drug pricing and discuss the potential of each to ensure value in response to unsustainable drug price increases.

  • Financial Conflicts of Interest Among Oncology Clinical Pathway Vendors

    Abstract Full Text
    free access
    JAMA Oncol. 2018; 4(2):255-257. 10.1001/jamaoncol.2017.4473

    This study examines the nonresearch payments received by committee and board members of oncology clinical pathway vendors.

  • Association of Hospital Costs With Complications Following Total Gastrectomy for Gastric Adenocarcinoma

    Abstract Full Text
    free access
    JAMA Surg. 2017; 152(10):953-958. 10.1001/jamasurg.2017.1718

    This study describes the effect of postoperative complications on hospital costs following total gastrectomy for gastric adenocarcinoma.

  • FDA Approval of Tisagenlecleucel: Promise and Complexities of a $475 000 Cancer Drug

    Abstract Full Text
    JAMA. 2017; 318(19):1861-1862. 10.1001/jama.2017.15218

    This Viewpoint uses FDA approval of tisagenlecleucel, the first chimeric antigen receptor T-cell (CAR-T) agent approved for human use, to discuss escalating drug prices for oncology therapies and the complex considerations of outcomes and value that should justify the pricing.