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  • Thrombectomy With the pRESET vs Solitaire Stent Retrievers as First-Line Large Vessel Occlusion Stroke Treatment: A Randomized Clinical Trial

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    Ƶ Neurol. 2024; 81(2):170-178. 10.1001/jamaneurol.2023.5010

    This randomized clinical trial evaluates whether thrombectomy for large vessel occlusion stroke with the pRESET stent retriever is noninferior to treatment with the Solitaire stent retriever.

  • Endovascular Therapy vs Medical Management for Patients With Acute Stroke With Medium Vessel Occlusion in the Anterior Circulation

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    Ƶ Netw Open. 2022; 5(10):e2238154. 10.1001/jamanetworkopen.2022.38154

    This cohort study compares the safety and efficacy outcomes associated with endovascular therapy vs medical management alone in the treatment of distal, medium vessel occlusion.

  • Data Do Not Support Selection by Target Perfusion Mismatch of Patients for Endovascular Stroke Treatment Within the 16- to 24-Hour Interval—Reply

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    Ƶ Neurol. 2022; 79(4):418-419. 10.1001/jamaneurol.2021.5405
  • Noncontrast Computed Tomography vs Computed Tomography Perfusion or Magnetic Resonance Imaging Selection in Late Presentation of Stroke With Large-Vessel Occlusion

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    Ƶ Neurol. 2021; 79(1):22-31. 10.1001/jamaneurol.2021.4082

    This cohort study compares the clinical outcomes of patients with stroke who presented 6 to 24 hours after symptom onset and were selected for mechanical thrombectomy by noncontrast computed tomography vs those selected by computed tomography perfusion or magnetic resonance imaging.

  • Assessment of Discrepancies Between Follow-up Infarct Volume and 90-Day Outcomes Among Patients With Ischemic Stroke Who Received Endovascular Therapy

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    Ƶ Netw Open. 2021; 4(11):e2132376. 10.1001/jamanetworkopen.2021.32376

    This cohort study validates exploratory findings from the Endovascular Treatment for Small Core and Anterior Circulation Proximal Occlusion with Emphasis on Minimizing CT to Recanalization Times (ESCAPE) trial regarding pretreatment, treatment, and posttreatment factors associated with discrepancies between follow-up infarct volume and 90-day functional outcome.

  • Assessment of Optimal Patient Selection for Endovascular Thrombectomy Beyond 6 Hours After Symptom Onset: A Pooled Analysis of the AURORA Database

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    Ƶ Neurol. 2021; 78(9):1064-1071. 10.1001/jamaneurol.2021.2319

    This pooled analysis uses data from 6 randomized clinical trials to assess the potential benefits of endovascular thrombectomy among patients with ischemic stroke based on 3 baseline imaging profiles.

  • Effect of Endovascular Treatment Alone vs Intravenous Alteplase Plus Endovascular Treatment on Functional Independence in Patients With Acute Ischemic Stroke: The DEVT Randomized Clinical Trial

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    JAMA. 2021; 325(3):234-243. 10.1001/jama.2020.23523

    This noninferiority trial compares the effects of endovascular treatment with vs without intravenous alteplase on 90-day functional independence among patients with acute ischemic stroke.

  • Importance of the Intention-to-Treat Principle

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    Ƶ Neurol. 2020; 77(7):905-906. 10.1001/jamaneurol.2020.0848
  • Mediation of the Relationship Between Endovascular Therapy and Functional Outcome by Follow-up Infarct Volume in Patients With Acute Ischemic Stroke

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    Ƶ Neurol. 2019; 76(2):194-202. 10.1001/jamaneurol.2018.3661

    This pooled data analysis of 7 randomized clinical trials of thrombectomy for acute ischemic stroke examines whether follow-up infarct volume mediates the relationship between endovascular therapy and functional outcome in patients with acute ischemic stroke.

  • Current Understanding and Gaps in Research of Carotid Webs in Ischemic Strokes: A Review

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    Ƶ Neurol. 2018; 76(3):355-361. 10.1001/jamaneurol.2018.3366

    This narrative review addresses the current understanding of carotid webs as a modifiable risk factor for stroke.

  • Safety and Efficacy of a 3-Dimensional Stent Retriever With Aspiration-Based Thrombectomy vs Aspiration-Based Thrombectomy Alone in Acute Ischemic Stroke Intervention: A Randomized Clinical Trial

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    Ƶ Neurol. 2018; 75(3):304-311. 10.1001/jamaneurol.2017.3967

    This randomized clinical noninferiority trial assesses a novel 3-dimensional stent retriever when used in conjunction with aspiration-based mechanical thrombectomy compared with aspiration-based mechanical thrombectomy alone in patients with acute ischemic stroke.

  • Monitored Anesthesia Care vs Intubation for Vertebrobasilar Stroke Endovascular Therapy

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    Ƶ Neurol. 2017; 74(6):704-709. 10.1001/jamaneurol.2017.0192

    This case-control study compares clinical and angiographic outcomes between monitored anesthesia care and general anesthesia in patients presenting with vertebrobasilar occlusion strokes.

  • Combined Intravenous Thrombolysis and Thrombectomy vs Thrombectomy Alone for Acute Ischemic Stroke: A Pooled Analysis of the SWIFT and STAR Studies

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    Ƶ Neurol. 2017; 74(3):268-274. 10.1001/jamaneurol.2016.5374

    This study examines whether treatment with intravenous thrombolysis before mechanical thrombectomy with a stent retriever is beneficial in patients undergoing mechanical thrombectomy.

  • Endovascular Treatment for Patients With Acute Stroke Who Have a Large Ischemic Core and Large Mismatch Imaging Profile

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    Ƶ Neurol. 2017; 74(1):34-40. 10.1001/jamaneurol.2016.3954

    This case-control study compares the outcomes of patients following stroke with large baseline ischemic cores on computed tomographic perfusion undergoing endovascular therapy with the outcomes of matched controls who had medical care alone.

  • Time to Treatment With Endovascular Thrombectomy and Outcomes From Ischemic Stroke: A Meta-analysis

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    JAMA. 2016; 316(12):1279-1289. 10.1001/jama.2016.13647

    This meta-analysis of trials comparing treatment of acute ischemic stroke with vs without endovascular thrombectomy characterizes the threshold time after which treatment is no longer beneficial.

  • Prognosis of Untreated Strokes Due to Anterior Circulation Proximal Intracranial Arterial Occlusions Detected by Use of Computed Tomography Angiography

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    Ƶ Neurol. 2014; 71(2):151-157. 10.1001/jamaneurol.2013.5007

    In a prospective cohort study at 2 university-based hospitals between 2003 and 2005, Lima and coauthors investigate the outcomes of patients who had an acute ischemic stroke attributable to an anterior circulation proximal intracranial arterial occlusion. See the editorial by Yahgi and Marshall.

  • Comparison of Final Infarct Volumes in Patients Who Received Endovascular Therapy or Intravenous Thrombolysis for Acute Intracranial Large-Vessel Occlusions

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    Ƶ Neurol. 2013; 70(7):831-836. 10.1001/jamaneurol.2013.413

    In a retrospective cohort study, Rangaraju and coauthors assess whether patients with intracranial large-vessel occlusions who received intra-arterial therapy have smaller final infarct volumes than patients who received either intravenous tissue plasminogen activator therapy or no reperfusion therapy. See the editorial by Adams and Froehler.

  • The Neurology of Varicella-Zoster Virus: A Historical Perspective

    Abstract Full Text
    Arch Neurol. 2004; 61(12):1974-1977. 10.1001/archneur.61.12.1974