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  • JAMA Original Investigation
    April 22, 2024

    Associations Between Surrogate Markers and Clinical Outcomes for Nononcologic Chronic Disease Treatments

    Joshua D.听Wallach,听PhD, MS; Samuel听Yoon,听BS, BA; Harry听Doernberg,听MM; Laura R.听Glick,听MD; Oriana听Ciani,听PhD; Rod S.听Taylor,听PhD; Maryam听Mooghali,听MD; Reshma听Ramachandran,听MD, MHS, MPP; Joseph S.听Ross,听MD, MHS
    Abstract Full Text
    online first
    JAMA. 2024; 10.1001/jama.2024.4175

    This study examines the strength of association between surrogate markers used as primary end points in clinical trials to support FDA approval of drugs treating nononcologic chronic diseases and clinical outcomes.