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  • Endovascular Thrombectomy Treatment Effect in Direct vs Transferred Patients With Large Ischemic Strokes: A Prespecified Analysis of the SELECT2 Trial

    Abstract Full Text
    ÁñÁ«ÊÓƵ Neurol. 2024; 81(4):327-335. 10.1001/jamaneurol.2024.0206

    This prespecified analysis of the SELECT2 trial assesses endovascular thrombectomy treatment effects in transferred vs directly presenting patients and evaluates the association between transfer times and neuroimaging changes with endovascular thrombectomy clinical outcomes.

  • Endovascular Thrombectomy for Large Ischemic Stroke Across Ischemic Injury and Penumbra Profiles

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    JAMA. 2024; 331(9):750-763. 10.1001/jama.2024.0572

    This exploratory analysis of the SELECT2 trial assesses the relationship between imaging estimates of irreversibly injured brain (core) and at-risk regions (mismatch) and the association of mismatch with clinical outcomes and endovascular treatment effect in adult patients with acute ischemic stroke due to occlusion of the internal carotid or middle cerebral artery and large ischemic core in 31 global centers between October 2019 and September 2022.

  • Thrombectomy With the pRESET vs Solitaire Stent Retrievers as First-Line Large Vessel Occlusion Stroke Treatment: A Randomized Clinical Trial

    Abstract Full Text
    open access
    ÁñÁ«ÊÓƵ Neurol. 2024; 81(2):170-178. 10.1001/jamaneurol.2023.5010

    This randomized clinical trial evaluates whether thrombectomy for large vessel occlusion stroke with the pRESET stent retriever is noninferior to treatment with the Solitaire stent retriever.

  • Functional and Safety Outcomes of Carotid Artery Stenting and Mechanical Thrombectomy for Large Vessel Occlusion Ischemic Stroke With Tandem Lesions

    Abstract Full Text
    open access
    ÁñÁ«ÊÓƵ Netw Open. 2023; 6(3):e230736. 10.1001/jamanetworkopen.2023.0736

    This cross-sectional study evaluates the clinical and technical outcomes of carotid artery stenting vs no stenting during mechanical thrombectomy in patients with acute large vessel occlusion strokes and concomitant tandem lesions.

  • Association of Endovascular Thrombectomy vs Medical Management With Functional and Safety Outcomes in Patients Treated Beyond 24 Hours of Last Known Well: The SELECT Late Study

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    free access has multimedia
    ÁñÁ«ÊÓƵ Neurol. 2022; 80(2):172-182. 10.1001/jamaneurol.2022.4714

    This cohort study analyzes data for patients who were treated beyond 24 hours after they were last known well to determine functional and safety outcomes for endovascular thrombectomy vs best medical management.

  • Endovascular Therapy vs Medical Management for Patients With Acute Stroke With Medium Vessel Occlusion in the Anterior Circulation

    Abstract Full Text
    open access
    ÁñÁ«ÊÓƵ Netw Open. 2022; 5(10):e2238154. 10.1001/jamanetworkopen.2022.38154

    This cohort study compares the safety and efficacy outcomes associated with endovascular therapy vs medical management alone in the treatment of distal, medium vessel occlusion.

  • Noncontrast Computed Tomography vs Computed Tomography Perfusion or Magnetic Resonance Imaging Selection in Late Presentation of Stroke With Large-Vessel Occlusion

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    open access is active quiz
    ÁñÁ«ÊÓƵ Neurol. 2021; 79(1):22-31. 10.1001/jamaneurol.2021.4082

    This cohort study compares the clinical outcomes of patients with stroke who presented 6 to 24 hours after symptom onset and were selected for mechanical thrombectomy by noncontrast computed tomography vs those selected by computed tomography perfusion or magnetic resonance imaging.

  • Association of Thrombectomy With Stroke Outcomes Among Patient Subgroups: Secondary Analyses of the DEFUSE 3 Randomized Clinical Trial

    Abstract Full Text
    free access
    ÁñÁ«ÊÓƵ Neurol. 2019; 76(4):447-453. 10.1001/jamaneurol.2018.4587

    This secondary analysis of a randomized clinical trial determines the association of thrombectomy among patients by age, symptom severity, time to randomization, arterial occlusive lesion location, and imaging modality.

  • Status Epilepticus–Induced Hyperemia and Brain Tissue Hypoxia After Cardiac Arrest

    Abstract Full Text
    free access
    Arch Neurol. 2011; 68(10):1323-1326. 10.1001/archneurol.2011.240