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This Viewpoint discusses the challenges involved with secondary health care data collection vs primary data collection and provides a list of suggested data checks before registration of a study protocol using secondary data.

This descriptive analysis aims to determine the prevalence of pretreatment testing that is recommended for patients with chronic inflammatory skin diseases (psoriasis, hidradenitis suppurativa, or atopic dermatitis).

This systematic review assesses the reporting of observational studies that explicitly aimed to emulate target trials, hypothetical randomized trials that could answer causal questions of interest.

This study uses results from randomized clinical trials as a reference to learn whether similar clinical conclusions could be drawn had the RCT protocol been translated and implemented as a database study protocol.

This cohort study uses insurance claims data to estimate the 6-month rate of infections among children with psoriasis who started treatment with ustekinumab, etanercept, or methotrexate.

This comparative effectiveness study evaluates the association of empagliflozin with cardiovascular outcomes compared with liraglutide and sitagliptin among older adults with type 2 diabetes and diverse characteristics.

This cohort study compares incidence of Alzheimer disease and related dementia among Medicare patients with rheumatoid arthritis using disease-modifying antirheumatic drugs.

This cohort study assesses the association between receiving the Ad26.COV2.S vaccine and COVID-19–related infections and hospitalizations before and during the Delta variant surge.

This cohort study examines the incidence of venous thromboembolism in patients with chronic inflammatory skin diseases.

This cohort study evaluates the risk of developing inflammatory arthritis among patients with hidradenitis suppurativa.

This prognostic study compares several machine learning approaches with traditional logistic regression for development of predictive models for all-cause mortality, heart failure hospitalization, high cost, and loss in home time, among patients with heart failure.

This cohort study assesses the association between initiation of sodium-glucose cotransporter 2 (SGLT-2) inhibitor treatment and the risk of hospitalization for Fournier gangrene among men.

This observational study examines the use of sevelamer vs calcium acetate for treatment of hyperphosphatemia in patients 65 years or older with end-stage renal disease who are undergoing hemodialysis.

This study examines whether longitudinal data from a health care database can support the results of a randomized clinical trial that led to a supplemental indication of telmisartan.