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This Viewpoint discusses the challenges involved with secondary health care data collection vs primary data collection and provides a list of suggested data checks before registration of a study protocol using secondary data.

This study uses results from randomized clinical trials as a reference to learn whether similar clinical conclusions could be drawn had the RCT protocol been translated and implemented as a database study protocol.

This prognostic study compares several machine learning approaches with traditional logistic regression for development of predictive models for all-cause mortality, heart failure hospitalization, high cost, and loss in home time, among patients with heart failure.

This pharmacoepidemiology study uses commercial claims database data to describe the rate of opioid overdose 1 to 3 months after surgical discharge by dose and procedure from 2004 to 2015.