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  • JAMA Cardiology Original Investigation
    February 21, 2024

    Effects of Pitavastatin on Coronary Artery Disease and Inflammatory Biomarkers in HIV: Mechanistic Substudy of the REPRIEVE Randomized Clinical Trial

    Michael T.听Lu,听惭顿, MPH; Heather聽Ribaudo,聽PhD; Borek聽Foldyna,听惭顿; Markella V.听Zanni,听惭顿; Thomas聽Mayrhofer,聽PhD; Julia聽Karady,听惭顿, PhD; Jana聽Taron,听惭顿; Kathleen V.听Fitch,聽MSN; Sara聽McCallum,聽MPH; Tricia H.听Burdo,聽PhD; Kayla聽Paradis,聽MBA; Sandeep S.听Hedgire,听惭顿; Nandini M.听Meyersohn,听惭顿; Christopher聽DeFilippi,听惭顿; Carlos D.听Malvestutto,听惭顿, MPH; Audra聽Sturniolo,聽MS; Marissa聽Diggs,聽BA; Sue聽Siminski,聽MBA; Gerald S.听Bloomfield,听惭顿; Beverly聽Alston-Smith,听惭顿; Patrice聽Desvigne-Nickens,听惭顿; Edgar T.听Overton,听惭顿; Judith S.听Currier,听惭顿; Judith A.听Aberg,听惭顿; Carl J.听Fichtenbaum,听惭顿; Udo聽Hoffmann,听惭顿, MPH; Pamela S.听Douglas,听惭顿; Steven K.听Grinspoon,听惭顿; REPRIEVE Trial Writing Group
    Abstract Full Text
    open access has multimedia
    JAMA Cardiol. 2024; 9(4):323-334. 10.1001/jamacardio.2023.5661

    This substudy of a randomized clinical trial investigates the effects of pitavastatin on noncalcified coronary artery plaque using coronary computed tomography angiography and on inflammatory biomarkers as potential mechanisms for major adverse cardiovascular event prevention.

  • JAMA Cardiology Brief Report
    December 13, 2023

    Mineralocorticoid Receptor Antagonism by Eplerenone and Arterial Inflammation in HIV: The MIRABELLA HIV Study

    Suman聽Srinivasa,听惭顿; Shady聽Abohashem,听惭顿; Allie R.听Walpert,聽MSN; Carolyn N.听Dunderdale,聽BA; Sanjna聽Iyengar,聽BS; Grace聽Shen,聽BS; Michael聽Jerosch-Herold,聽PhD; Christopher R.听deFilippi,听惭顿; Gregory K.听Robbins,听惭顿; Hang聽Lee,聽PhD; Raymond Y.听Kwong,听惭顿; Gail K.听Adler,听惭顿, PhD; Ahmed聽Tawakol,听惭顿; Steven K.听Grinspoon,听惭顿
    Abstract Full Text
    JAMA Cardiol. 2023; 9(2):189-194. 10.1001/jamacardio.2023.4578

    This randomized clinical trial investigates if treatment with a mineralocorticoid receptor antagonist reduces arterial inflammation on 18F-fludeoxyglucose鈥損ositron emission tomography/computed tomography among persons with HIV.

  • 榴莲视频 Network Open Original Investigation Cardiology
    June 29, 2021

    Assessment of Coronary Artery Disease With Computed Tomography Angiography and Inflammatory and Immune Activation Biomarkers Among Adults With HIV Eligible for Primary Cardiovascular Prevention

    Udo聽Hoffmann,听惭顿, MPH; Michael T.听Lu,听惭顿, MPH; Borek聽Foldyna,听惭顿; Markella V.听Zanni,听惭顿; Julia聽Karady,听惭顿; Jana聽Taron,听惭顿; Bingxue K.听Zhai,聽MS; Tricia聽Burdo,聽PhD; Kathleen V.听Fitch,聽MSN; Emma M.听Kileel,聽MPH; Kenneth聽Williams,聽PhD; Carl J.听Fichtenbaum,听惭顿; Edgar T.听Overton,听惭顿; Carlos聽Malvestutto,听惭顿; Judith聽Aberg,听惭顿; Judith聽Currier,听惭顿; Craig A.听Sponseller,听惭顿; Kathleen聽Melbourne,聽PharmD; Michelle聽Floris-Moore,听惭顿; Cornelius聽Van Dam,听惭顿; Michael C.听Keefer,听惭顿; Susan L.听Koletar,听惭顿; Pamela S.听Douglas,听惭顿; Heather聽Ribaudo,聽PhD; Thomas聽Mayrhofer,聽PhD; Steven K.听Grinspoon,听惭顿; REPRIEVE trial
    Abstract Full Text
    open access
    榴莲视频 Netw Open. 2021; 4(6):e2114923. 10.1001/jamanetworkopen.2021.14923

    This cohort study examines the prevalence of coronary artery disease (CAD) among adults with well-controlled HIV and low to moderate risk of atherosclerotic cardiovascular disease using computed tomography angiography and assessment of inflammation and immune activation biomarkers.

  • JAMA Cardiology Brief Report
    July 1, 2016

    Effects of Antiretroviral Therapy on Immune Function and Arterial Inflammation in Treatment-Naive Patients With Human Immunodeficiency Virus Infection

    Markella V.听Zanni,听惭顿; Mabel聽Toribio,听惭顿; Gregory K.听Robbins,听惭顿; Tricia H.听Burdo,聽PhD; Michael T.听Lu,听惭顿; Amorina E.听Ishai,听惭顿; Meghan N.听Feldpausch,聽NP; Amanda聽Martin,聽AB; Kathy聽Melbourne,聽PharmD; Virginia A.听Triant,听惭顿, MPH; Sujit聽Suchindran,听惭顿; Hang聽Lee,聽PhD; Udo聽Hoffmann,听惭顿, MPH; Kenneth C.听Williams,聽PhD; Ahmed聽Tawakol,听惭顿; Steven K.听Grinspoon,听惭顿
    Abstract Full Text
    free access
    JAMA Cardiol. 2016; 1(4):474-480. 10.1001/jamacardio.2016.0846

    This study evaluates the effects of newly initiated antiretroviral therapy (ART) on arterial inflammation and other immune/inflammatory indices in ART-naive patients with human immunodeficiency virus infection.

  • JAMA Original Investigation
    July 23, 2014

    Effect of Tesamorelin on Visceral Fat and Liver Fat in HIV-Infected Patients With Abdominal Fat Accumulation: A Randomized Clinical Trial

    Takara L.听Stanley,听惭顿; Meghan N.听Feldpausch,聽APRN-BC; Jinhee聽Oh,聽BA; Karen L.听Branch,聽RN; Hang聽Lee,聽PhD; Martin聽Torriani,听惭顿; Steven K.听Grinspoon,听惭顿
    Abstract Full Text
    free access
    JAMA. 2014; 312(4):380-389. 10.1001/jama.2014.8334

    Stanley and coauthors conducted a randomized clinical trial among 50 antiretroviral-treated men and women with human immunodefiency virus infection (HIV) and abdominal fat accumulation to investigate the effect of the growth hormone鈥搑eleasing hormone analog tesamorelin on visceral adipose tissue and liver fat.

  • JAMA Preliminary Communication
    July 25, 2012

    Arterial Inflammation in Patients With HIV

    Sharath Subramanian, MD; Ahmed Tawakol, MD; Tricia H. Burdo, PhD; Suhny Abbara, MD; Jeffrey Wei, BA; Jayanthi Vijayakumar, MD; Erin Corsini, BS; Amr Abdelbaky, MD; Markella V. Zanni, MD; Udo Hoffmann, MD, MPH; Kenneth C. Williams, PhD; Janet Lo, MD, MMSc; Steven K. Grinspoon, MD
    Abstract Full Text
    free access
    JAMA. 2012; 308(4):379-386. 10.1001/jama.2012.6698
    Subramanian and coauthors assess arterial wall inflammation in human immunodeficiency virus using 18fluorine-2-deoxy-D-glucose positron emission tomography in relationship to traditional and nontraditional risk markers, including soluble CD163. See the related Editorial by Stein and Hsue.
  • JAMA Internal Medicine Original Investigation
    April 24, 2006

    Effects of Etanercept in Patients With the Metabolic Syndrome

    L. Elizabeth Bernstein, MD; Jacqueline Berry, BA; Sunnie Kim, BA; Bridget Canavan, BA; Steven K. Grinspoon, MD
    Abstract Full Text
    free access
    Arch Intern Med. 2006; 166(8):902-908. 10.1001/archinte.166.8.902
  • JAMA Internal Medicine Original Investigation
    March 14, 2005

    Medical Findings in Outpatients With Anorexia Nervosa

    Karen K. Miller, MD; Steven K. Grinspoon, MD; Julia Ciampa, AB; Joan Hier, AB; David Herzog, MD; Anne Klibanski, MD
    Abstract Full Text
    free access
    Arch Intern Med. 2005; 165(5):561-566. 10.1001/archinte.165.5.561