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  • Early vs Late Anticoagulation in Minor, Moderate, and Major Ischemic Stroke With Atrial Fibrillation: Post Hoc Analysis of the ELAN Randomized Clinical Trial

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    ÁñÁ«ÊÓƵ Neurol. 2024; 10.1001/jamaneurol.2024.1450

    This post hoc analysis of the ELAN randomized clinical trial investigates whether infarct size modifies the safety and efficacy of early vs late direct oral anticoagulation initiation after ischemic stroke in individuals with atrial fibrillation.

  • Time to IVT Treatment and Functional Outcomes in Acute Ischemic Stroke—Reply

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    JAMA. 2024; 10.1001/jama.2024.7979
  • Time to Treatment With Intravenous Thrombolysis Before Thrombectomy and Functional Outcomes in Acute Ischemic Stroke: A Meta-Analysis

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    JAMA. 2024; 331(9):764-777. 10.1001/jama.2024.0589

    This individual participant data meta-analysis assesses treatment time from stroke symptom onset and disability level after treatment with intravenous thrombolysis plus thrombectomy vs thrombectomy alone among patients who presented directly at thrombectomy-capable stroke centers.

  • Immunoglobulin A Antibodies Against Myelin Oligodendrocyte Glycoprotein in a Subgroup of Patients With Central Nervous System Demyelination

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    ÁñÁ«ÊÓƵ Neurol. 2023; 80(9):989-995. 10.1001/jamaneurol.2023.2523

    This cross-sectional study examines laboratory and imaging data for patients with demyelinating central nervous system disease to investigate the frequency of MOG-IgA and associated clinical features.

  • Association Between Intravenous Thrombolysis and Clinical Outcomes Among Patients With Ischemic Stroke and Unsuccessful Mechanical Reperfusion

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    ÁñÁ«ÊÓƵ Netw Open. 2023; 6(5):e2310213. 10.1001/jamanetworkopen.2023.10213

    This cohort study investigates the potential treatment benefit of intravenous thrombolysis in patients with acute ischemic stroke due to large-vessel occlusion in whom successful mechanical reperfusion was not achieved.

  • Serum Glial Fibrillary Acidic Protein Compared With Neurofilament Light Chain as a Biomarker for Disease Progression in Multiple Sclerosis

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    ÁñÁ«ÊÓƵ Neurol. 2023; 80(3):287-297. 10.1001/jamaneurol.2022.5250

    This cohort study investigates if concentrations of serum glial fibrillary acidic protein and neurofilament light chain are associated with and prognostic for disease progression in patients with multiple sclerosis.

  • Intravenous Thrombolysis in Patients With Ischemic Stroke and Recent Ingestion of Direct Oral Anticoagulants

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    ÁñÁ«ÊÓƵ Neurol. 2023; 80(3):233-243. 10.1001/jamaneurol.2022.4782

    This cohort study evaluates the risk of symptomatic intracranial hemorrhage associated with use of intravenous thrombolysis in patients with recent direct oral anticoagulant ingestion.

  • Noncontrast Computed Tomography vs Computed Tomography Perfusion or Magnetic Resonance Imaging Selection in Late Presentation of Stroke With Large-Vessel Occlusion

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    ÁñÁ«ÊÓƵ Neurol. 2021; 79(1):22-31. 10.1001/jamaneurol.2021.4082

    This cohort study compares the clinical outcomes of patients with stroke who presented 6 to 24 hours after symptom onset and were selected for mechanical thrombectomy by noncontrast computed tomography vs those selected by computed tomography perfusion or magnetic resonance imaging.

  • Frequency of Thrombocytopenia and Platelet Factor 4/Heparin Antibodies in Patients With Cerebral Venous Sinus Thrombosis Prior to the COVID-19 Pandemic

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    JAMA. 2021; 326(4):332-338. 10.1001/jama.2021.9889

    This retrospective analysis examined the frequency of thrombocytopenia and heparin-induced thrombocytopenia among patients with cerebral venous sinus thrombosis (CVST) before COVID-19 to help elucidate the association of ChAdOx1 nCoV-19 and Ad26.COV2.S vaccines and CVST thrombocytopenia.

  • Thrombectomy for Primary Distal Posterior Cerebral Artery Occlusion Stroke: The TOPMOST Study

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    ÁñÁ«ÊÓƵ Neurol. 2021; 78(4):434-444. 10.1001/jamaneurol.2021.0001

    This case-control study analyzes the clinical, functional, and safety outcomes associated with endovascular therapy for patients with posterior circulation distal, medium vessel occlusion.

  • Safety and Efficacy of Intra-arterial Urokinase After Failed, Unsuccessful, or Incomplete Mechanical Thrombectomy in Anterior Circulation Large-Vessel Occlusion Stroke

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    ÁñÁ«ÊÓƵ Neurol. 2019; 77(3):318-326. 10.1001/jamaneurol.2019.4192

    This cohort study assesses whether administration of intra-arterial urokinase is safe and improves reperfusion among patients who have undergone failed or incomplete mechanical thrombectomy.

  • Episodic Visual Snow Associated With Migraine Attacks

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    ÁñÁ«ÊÓƵ Neurol. 2019; 77(3):392-393. 10.1001/jamaneurol.2019.4050

    This case series describes 3 individuals with episodic visual snow, co-occurring with migraines.

  • Development and Validation of a Prognostic Model of Swallowing Recovery and Enteral Tube Feeding After Ischemic Stroke

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    ÁñÁ«ÊÓƵ Neurol. 2019; 76(5):561-570. 10.1001/jamaneurol.2018.4858

    This validation study describes the development of a prognostic model to predict swallowing recovery and guide the decision for enteral tube feeding in people with dysphagia after ischemic stroke.

  • Combined Intravenous Thrombolysis and Thrombectomy vs Thrombectomy Alone for Acute Ischemic Stroke: A Pooled Analysis of the SWIFT and STAR Studies

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    ÁñÁ«ÊÓƵ Neurol. 2017; 74(3):268-274. 10.1001/jamaneurol.2016.5374

    This study examines whether treatment with intravenous thrombolysis before mechanical thrombectomy with a stent retriever is beneficial in patients undergoing mechanical thrombectomy.