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  • Omission of Axillary Dissection Following Nodal Downstaging With Neoadjuvant Chemotherapy

    Abstract Full Text
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    JAMA Oncol. 2024; 10.1001/jamaoncol.2024.0578

    This cohort study examines oncological outcomes after sentinel lymph node biopsy with dual-tracer mapping or targeted axillary dissection.

  • Premastectomy Radiotherapy and Immediate Breast Reconstruction: A Randomized Clinical Trial

    Abstract Full Text
    open access
    ÁñÁ«ÊÓƵ Netw Open. 2024; 7(4):e245217. 10.1001/jamanetworkopen.2024.5217

    This randomized clinical trial evaluates outcomes among patients who received premastectomy radiotherapy and regional nodal irradiation followed by mastectomy and immediate breast reconstruction.

  • Patient-Reported Outcomes of Omission of Breast Surgery Following Neoadjuvant Systemic Therapy: A Nonrandomized Clinical Trial

    Abstract Full Text
    open access
    ÁñÁ«ÊÓƵ Netw Open. 2023; 6(9):e2333933. 10.1001/jamanetworkopen.2023.33933

    This nonrandomized clinical trial evaluates patient-reported outcomes in a clinical trial evaluating omission of breast surgery for invasive cancers with exceptional response to neoadjuvant systemic therapy.

  • Accuracy of Post–Neoadjuvant Chemotherapy Image-Guided Breast Biopsy to Predict Residual Cancer

    Abstract Full Text
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    JAMA Surg. 2020; 155(12):e204103. 10.1001/jamasurg.2020.4103

    This diagnostic study assesses the accuracy of post–neoadjuvant chemotherapy image-guided biopsy to predict residual cancer in the breast.

  • Effectiveness of Breast-Conserving Surgery and 3-Dimensional Conformal Partial Breast Reirradiation for Recurrence of Breast Cancer in the Ipsilateral Breast: The NRG Oncology/RTOG 1014 Phase 2 Clinical Trial

    Abstract Full Text
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    JAMA Oncol. 2019; 6(1):75-82. 10.1001/jamaoncol.2019.4320

    This phase 2 clinical trial of patients with recurrence of breast cancer in the ipsilateral breast assesses the effectiveness of partial breast reirradiation after a second lumpectomy.

  • Factors Associated With Lymphedema in Women With Node-Positive Breast Cancer Treated With Neoadjuvant Chemotherapy and Axillary Dissection

    Abstract Full Text
    free access
    JAMA Surg. 2019; 154(9):800-809. 10.1001/jamasurg.2019.1742

    This cohort study examines factors associated with lymphedema after neoadjuvant chemotherapy and axillary lymph node dissection in women with node-positive breast cancer.

  • Association of Low Nodal Positivity Rate Among Patients With ERBB2 -Positive or Triple-Negative Breast Cancer and Breast Pathologic Complete Response to Neoadjuvant Chemotherapy

    Abstract Full Text
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    JAMA Surg. 2018; 153(12):1120-1126. 10.1001/jamasurg.2018.2696

    This study of the National Cancer Database evaluated the association of nodal positivity rates with a pathologic complete response to neoadjuvant chemotherapy among patients with cT1/cT2 cN0 triple-negative breast cancer or ERBB2-positive disease.

  • Incidence and Outcome of Breast Biopsy Procedures During Follow-up After Treatment for Breast Cancer

    Abstract Full Text
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    JAMA Surg. 2018; 153(6):559-568. 10.1001/jamasurg.2017.5572

    This population-based cohort study evaluates the incidence of invasive breast biopsy during the 10-year follow-up of women with breast cancer

  • Identification of Patients With Documented Pathologic Complete Response in the Breast After Neoadjuvant Chemotherapy for Omission of Axillary Surgery

    Abstract Full Text
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    JAMA Surg. 2017; 152(7):665-670. 10.1001/jamasurg.2017.0562

    This cohort study identifies patients with breast cancer and a pathologic complete response to neoadjuvant chemotherapy with a low risk for axillary metastases and possibly eligible for omission of surgery.

  • A Standard Set of Value-Based Patient-Centered Outcomes for Breast Cancer: The International Consortium for Health Outcomes Measurement (ICHOM) Initiative

    Abstract Full Text
    JAMA Oncol. 2017; 3(5):677-685. 10.1001/jamaoncol.2016.4851

    This Special Communication examines the development of a standard set of value-based patient-centered outcomes for breast cancer.

  • Ten-Year Outcomes of Patients With Breast Cancer With Cytologically Confirmed Axillary Lymph Node Metastases and Pathologic Complete Response After Primary Systemic Chemotherapy

    Abstract Full Text
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    JAMA Oncol. 2016; 2(4):508-516. 10.1001/jamaoncol.2015.4935

    This study investigates the long-term effect of axillary pathologic complete response on relapse-free and overall survival among women with breast cancer with cytologically confirmed axillary lymph node metastases treated with primary systemic chemotherapy.

  • Selective Surgical Localization of Axillary Lymph Nodes Containing Metastases in Patients With Breast Cancer: A Prospective Feasibility Trial

    Abstract Full Text
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    JAMA Surg. 2015; 150(2):137-143. 10.1001/jamasurg.2014.1086

    This prospective feasibility trial adds selective removal of clip-containing lymph nodes to sentinel lymph node dissection, with the possibility of identifying patients for limited nodal surgery after chemotherapy.

  • Racial Disparities in Adoption of Axillary Sentinel Lymph Node Biopsy and Lymphedema Risk in Women With Breast Cancer

    Abstract Full Text
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    JAMA Surg. 2014; 149(8):788-796. 10.1001/jamasurg.2014.23

    Black et al determine racial differences in the use of sentinel lymph node biopsy among patients with pathologically node-negative breast cancer during the period when sentinel lymph node biopsy became the preferred method for axillary staging as well as whether such differences affect lymphedema risk. See the Invited Commentary by Murphy and Schulick.

  • Sentinel Lymph Node Surgery After Neoadjuvant Chemotherapy in Patients With Node-Positive Breast Cancer: The ACOSOG Z1071 (Alliance) Clinical Trial

    Abstract Full Text
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    JAMA. 2013; 310(14):1455-1461. 10.1001/jama.2013.278932

    Boughey and coauthors determine the false-negative rate for sentinel lymph node (SLN) surgery following chemotherapy in 663 women initially presenting with biopsy-proven node-positive breast cancer. In an Editorial, Morrow and Dang discuss false-negative rates and their role in determining whether to use more aggressive therapies.