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  • Omission of Axillary Dissection Following Nodal Downstaging With Neoadjuvant Chemotherapy

    Abstract Full Text
    online first
    JAMA Oncol. 2024; 10.1001/jamaoncol.2024.0578

    This cohort study examines oncological outcomes after sentinel lymph node biopsy with dual-tracer mapping or targeted axillary dissection.

  • Race, Gene Expression Signatures, and Clinical Outcomes of Patients With High-Risk Early Breast Cancer

    Abstract Full Text
    open access
    ÁñÁ«ÊÓƵ Netw Open. 2023; 6(12):e2349646. 10.1001/jamanetworkopen.2023.49646

    This cohort study evaluates pathologic complete response and distant recurrence–free survival of early breast cancer by race and whether gene expression signatures correlate with outcomes.

  • Patient-Reported Outcomes of Omission of Breast Surgery Following Neoadjuvant Systemic Therapy: A Nonrandomized Clinical Trial

    Abstract Full Text
    open access
    ÁñÁ«ÊÓƵ Netw Open. 2023; 6(9):e2333933. 10.1001/jamanetworkopen.2023.33933

    This nonrandomized clinical trial evaluates patient-reported outcomes in a clinical trial evaluating omission of breast surgery for invasive cancers with exceptional response to neoadjuvant systemic therapy.

  • Association of Residual Ductal Carcinoma In Situ With Breast Cancer Recurrence in the Neoadjuvant I-SPY2 Trial

    Abstract Full Text
    free access
    JAMA Surg. 2022; 157(11):1034-1041. 10.1001/jamasurg.2022.4118

    This study examines the association of residual ductal carcinoma in situ in surgical specimens after neoadjuvant chemotherapy with breast cancer survival end points.

  • Assessment of Residual Cancer Burden and Event-Free Survival in Neoadjuvant Treatment for High-risk Breast Cancer: An Analysis of Data From the I-SPY2 Randomized Clinical Trial

    Abstract Full Text
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    JAMA Oncol. 2021; 7(11):1654-1663. 10.1001/jamaoncol.2021.3690

    This randomized clinical trial examines the distribution and prognosis of residual cancer burden across high-risk phenotypic subtypes of breast cancer and by different treatment groups.

  • Effect of Pembrolizumab Plus Neoadjuvant Chemotherapy on Pathologic Complete Response in Women With Early-Stage Breast Cancer: An Analysis of the Ongoing Phase 2 Adaptively Randomized I-SPY2 Trial

    Abstract Full Text
    free access
    JAMA Oncol. 2020; 6(5):676-684. 10.1001/jamaoncol.2019.6650

    This analysis of data from an ongoing open-label adaptively randomized phase 2 platform trial examines the efficacy of adding pembrolizumab to standard neoadjuvant chemotherapy in patients with early-stage, high-risk, ERBB2-negative breast cancer.

  • Factors Associated With Lymphedema in Women With Node-Positive Breast Cancer Treated With Neoadjuvant Chemotherapy and Axillary Dissection

    Abstract Full Text
    free access
    JAMA Surg. 2019; 154(9):800-809. 10.1001/jamasurg.2019.1742

    This cohort study examines factors associated with lymphedema after neoadjuvant chemotherapy and axillary lymph node dissection in women with node-positive breast cancer.

  • Disease-Free and Overall Survival Among Patients With Operable HER2-Positive Breast Cancer Treated With Sequential vs Concurrent Chemotherapy: The ACOSOG Z1041 (Alliance) Randomized Clinical Trial

    Abstract Full Text
    free access
    JAMA Oncol. 2019; 5(1):45-50. 10.1001/jamaoncol.2018.3691

    This phase 3 randomized clinical trial compares disease-free and overall survival among patients with operable HER2-positive breast cancer who received concurrent vs sequential administration of neoadjuvant chemotherapy.

  • Association of Low Nodal Positivity Rate Among Patients With ERBB2 -Positive or Triple-Negative Breast Cancer and Breast Pathologic Complete Response to Neoadjuvant Chemotherapy

    Abstract Full Text
    free access
    JAMA Surg. 2018; 153(12):1120-1126. 10.1001/jamasurg.2018.2696

    This study of the National Cancer Database evaluated the association of nodal positivity rates with a pathologic complete response to neoadjuvant chemotherapy among patients with cT1/cT2 cN0 triple-negative breast cancer or ERBB2-positive disease.

  • Sentinel Lymph Node Surgery After Neoadjuvant Chemotherapy in Patients With Node-Positive Breast Cancer: The ACOSOG Z1071 (Alliance) Clinical Trial

    Abstract Full Text
    free access
    JAMA. 2013; 310(14):1455-1461. 10.1001/jama.2013.278932

    Boughey and coauthors determine the false-negative rate for sentinel lymph node (SLN) surgery following chemotherapy in 663 women initially presenting with biopsy-proven node-positive breast cancer. In an Editorial, Morrow and Dang discuss false-negative rates and their role in determining whether to use more aggressive therapies.