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  • Omission of Axillary Dissection Following Nodal Downstaging With Neoadjuvant Chemotherapy

    Abstract Full Text
    online first
    JAMA Oncol. 2024; 10.1001/jamaoncol.2024.0578

    This cohort study examines oncological outcomes after sentinel lymph node biopsy with dual-tracer mapping or targeted axillary dissection.

  • Safety of Targeted Axillary Dissection After Neoadjuvant Therapy in Patients With Node-Positive Breast Cancer

    Abstract Full Text
    JAMA Surg. 2023; 158(8):807-815. 10.1001/jamasurg.2023.1772

    This cohort study assesses 3-year clinical outcomes in patients with node-positive breast cancer who underwent targeted axillary dissection alone or in combination with axillary lymph node dissection.

  • Efficacy of Endocrine Therapy Plus Trastuzumab and Pertuzumab vs De-escalated Chemotherapy in Patients with Hormone Receptor–Positive/ ERBB2 -Positive Early Breast Cancer: The Neoadjuvant WSG-TP-II Randomized Clinical Trial

    Abstract Full Text
    free access
    JAMA Oncol. 2023; 9(7):946-954. 10.1001/jamaoncol.2023.0646

    This randomized clinical trial aims to determine whether neoadjuvant de-escalated chemotherapy is superior to endocrine therapy, both in combination with pertuzumab and trastuzumab, in a highly heterogeneous hormone receptor–positive/ERBB2-positive early breast cancer.

  • Fulvestrant Plus Vistusertib vs Fulvestrant Plus Everolimus vs Fulvestrant Alone for Women With Hormone Receptor–Positive Metastatic Breast Cancer: The MANTA Phase 2 Randomized Clinical Trial

    Abstract Full Text
    open access
    JAMA Oncol. 2019; 5(11):1556-1564. 10.1001/jamaoncol.2019.2526

    This open-label phase 2 randomized clinical trial evaluates the safety and efficacy of vistusertib in combination with fulvestrant compared with fulvestrant alone or fulvestrant plus everolimus for women with hormone receptor–positive metastatic breast cancer.