To the Editor A recent study1 suggested clinical benefits of noninvasive airway management in comatose patients with acute poisoning. An accompanying editorial lauded the study as a practice-changing trial providing rigorous evidence.2 Although we have recommended against indiscriminate intubation of patients based on a low Glasgow Coma Scale (GCS) score,3,4 we are concerned about the ability of this study1 to provide conclusive evidence allowing a paradigm shift in clinical practice.