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This cohort study evaluates sex differences in age at diagnosis, risk factors, treatment, and cardiovascular morbidity and mortality in patients with homozygous familial hypercholesterolemia.

This substudy of a randomized clinical trial investigates the effects of pitavastatin on noncalcified coronary artery plaque using coronary computed tomography angiography and on inflammatory biomarkers as potential mechanisms for major adverse cardiovascular event prevention.

This cohort study investigates the association of accelerometer-measured physical activity and sedentary behavior with incident heart failure in older women.

This prespecified secondary analysis of the Diagnostic Imaging Strategies for Patients With Stable Chest Pain and Intermediate Risk of Coronary Artery Disease (DISCHARGE) randomized clinical trial investigates the association of age with clinical outcomes after computed tomography and coronary angiography in stable chest pain.

This cohort study evaluates a novel polygenic risk score for estimating risk of aortic stenosis compared with the use of established risk factors.

This cohort study examines the use of cardiopulmonary exercise testing in evaluating patients with transthyretin amyloidosis.

This diagnostic accuracy study examines whether deep learning models using 12-lead electrocardiography (ECG) can improve the detection of congenital long QT syndrome (LQTS) and differentiate between LQTS genotypes.