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April 22, 2024
Original Investigation

Effects of Tirofiban on Neurological Deterioration in Patients With Acute Ischemic Stroke: A Randomized Clinical Trial

Abstract Full Text
ÁñÁ«ÊÓƵ Neurol. Published online April 22, 2024. doi:10.1001/jamaneurol.2024.0868

This randomized clinical trial analyzes data for patients with acute noncardioembolic stroke who were given intravenous tirofiban within 24 hours of stroke onset to gauge its effect on early neurological deterioration compared with oral aspirin.

Images in Neurology

Cold-Induced Reflex Epilepsy

Abstract Full Text
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ÁñÁ«ÊÓƵ Neurol. Published online April 22, 2024. doi:10.1001/jamaneurol.2024.0884

This case report describes a woman cold-induced reflex seizures.

ÁñÁ«ÊÓƵ Neurology Clinical Challenge

A 24-Year-Old Man With Spastic Ataxia and Hypodontia

Abstract Full Text
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ÁñÁ«ÊÓƵ Neurol. Published online April 22, 2024. doi:10.1001/jamaneurol.2024.0890

A 24-year-old man presented with progressive gait instability, marked spinal cord atrophy, and dental radiography showing the absence of several elements, microdontia, and taurodontia. What is your diagnosis?

April 15, 2024
On the Brain

Entering Medicine as a Physician and a Patient

Abstract Full Text
ÁñÁ«ÊÓƵ Neurol. Published online April 15, 2024. doi:10.1001/jamaneurol.2024.0804

This essay describes the author’s experience with the line between life and death and what the fragility of life means for patients and their medical teams.

Original Investigation

Clinicopathologic Heterogeneity and Glial Activation Patterns in Alzheimer Disease

Abstract Full Text
open access
ÁñÁ«ÊÓƵ Neurol. Published online April 15, 2024. doi:10.1001/jamaneurol.2024.0784

This cross-sectional study evaluates the association between corticolimbic vulnerability to tau pathology as a continuous trait with clinicalpathologic heterogeneity and glial activation patterns in neuropathologically diagnosed Alzheimer disease.

Images in Neurology

A Rare Neurological Presentation of Kikuchi-Fujimoto Disease

Abstract Full Text
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ÁñÁ«ÊÓƵ Neurol. Published online April 15, 2024. doi:10.1001/jamaneurol.2024.0799

This case report describes a 17-year-old boy with reduced consciousness and T2-weighted hyperintensity, focal diffusion restriction, and microhemorrhages within the deep gray nuclei and surrounding white matter.

April 8, 2024
Viewpoint

Toward More Personalized Management of Device-Detected Atrial Fibrillation

Abstract Full Text
ÁñÁ«ÊÓƵ Neurol. Published online April 8, 2024. doi:10.1001/jamaneurol.2024.0673

This Viewpoint discusses the need to individualize the management of subclinical atrial fibrillation according to burden (among other factors) by modeling stroke risk.

Original Investigation

Early Seizure Prophylaxis in Mild and Moderate Traumatic Brain Injury: A Systematic Review and Meta-Analysis

Abstract Full Text
ÁñÁ«ÊÓƵ Neurol. Published online April 8, 2024. doi:10.1001/jamaneurol.2024.0689

This systematic review and meta-analysis investigates the association between seizure prophylaxis and risk reduction for early posttraumatic seizures.

Research Letter

Large Language Model Performance on Practice Epilepsy Board Examinations

Abstract Full Text
ÁñÁ«ÊÓƵ Neurol. Published online April 8, 2024. doi:10.1001/jamaneurol.2024.0676

This diagnostic study examines whether large language models are able to pass practice licensing examinations for epilepsy.

April 1, 2024
Original Investigation

Use of Recommended Neurodiagnostic Evaluation Among Patients With Drug-Resistant Epilepsy

Abstract Full Text
ÁñÁ«ÊÓƵ Neurol. Published online April 1, 2024. doi:10.1001/jamaneurol.2024.0551

This cross-sectional study examines the use of neurodiagnostic testing among patients with drug-resistant epilepsy.

Review

Progress in Pharmacologic Management of Neuropsychiatric Syndromes in Neurodegenerative Disorders: A Review

Abstract Full Text
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ÁñÁ«ÊÓƵ Neurol. Published online April 1, 2024. doi:10.1001/jamaneurol.2024.0586

This narrative review focuses on symptoms, occurrence, and appropriate management of neuropsychiatric syndromes in neurogenerative disorders.

Images in Neurology

Semantic Variant of Primary Progressive Aphasia With Glycine Receptor α1 Autoantibodies

Abstract Full Text
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ÁñÁ«ÊÓƵ Neurol. Published online April 1, 2024. doi:10.1001/jamaneurol.2024.0590

This case report describes a 54-year-old woman with naming deficits, comprehension impairment, and memory loss. Initial physical and neurological examination results were unremarkable.

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