This cluster-randomized clinical trial examines the effects of the Million Hearts Model on first-time myocardial infarctions and strokes and Medicare spending over a period up to 5 years.
This open-label, single-group, phase 3 trial evaluates eplontersen, an investigational ligand-conjugated antisense oligonucleotide, in adults with hereditary amyloid transthyretin (ATTRv) polyneuropathy at 40 sites in 15 countries, compared with historical controls.
This individual participant data meta-analysis assesses the effect of a lower blood pressure (BP) treatment goal or active therapy vs a standard BP treatment goal or placebo on cardiovascular disease or all-cause mortality among adults with orthostatic hypotension or standing hypotension.
This study uses data from the 2013鈥揗arch 2020 National Health and Nutrition Examination Survey to assess contemporary patterns of risky alcohol use among adults taking high-risk alcohol-interactive medications (benzodiazepine receptor agonists, opioids, and antiepileptics).
In this Viewpoint, Lasker Award winner Piet Borst looks back over a 50-year career in scientific research, including work with trypanosomatids, mechanisms of drug resistance in cancer cells, and inborn errors of metabolism.
In this Viewpoint, 2023 Lasker award winners John Jumper and Demis Hassabis describe their invention, the artificial intelligence鈥揵ased system AlphaFold, which is able to predict protein structure with great accuracy.
In this Viewpoint, 2023 Lasker-DeBakey Clinical Medical Research Award winners James G. Fujimoto, David Huang, and Eric A. Swanson discuss their invention鈥攐ptical coherence tomography, which allows rapid detection of diseases of the retina that impair vision.
In this narrative medicine essay, an emergency medicine pediatrician describes the care his mother received in her last days and calls on the health care profession to aim for providing a personal touch when caring for patients.
This review summarizes current evidence regarding the pathophysiology, clinical presentation, and treatment of hyperthyroidism, focusing on the management of Graves disease and toxic nodular disease.
This JAMA Guide to Statistics and Methods explains the use of historical controls鈥攑ersons who had received a specific control treatment in a previous study鈥攚hen randomizing participants to that control treatment in a subsequent trial may not be practical or ethical.
This JAMA Insights in the Women鈥檚 Health series discusses diagnosis of uterine prolapse and available surgical and nonsurgical treatment options.
This Medical News story examines the complexity of determining who to treat with lecanemab, the new Alzheimer disease drug.
In this Medical News article, Ida Sim, MD, PhD, a primary care physician and computational precision health expert at the University of California, San Francisco, discusses the ramifications of using AI technologies in patient care.
This Medical News article discusses the new COVID-19 vaccine and recommendations for fall 2023.
This JAMA Patient Page describes the types of nonprescription heartburn medications: antacids, histamine 2 blockers, and proton pump inhibitors.