January 1, 2020 Issue of JAMA Ophthalmology

January 2020, Vol 138, No. 1, Pages 3-105

In This Issue of JAMA Ophthalmology

Highlights

Abstract Full Text

free access

JAMA Ophthalmol. 2020;138(1):3. doi:10.1001/jamaophthalmol.2019.0341

Viewpoint

Clinical Practice Settings vs Clinical Trials: Is Artificial Intelligence the Answer?

Lee Merrill Jampol, MD; Ursula M. Schmidt-Erfurth, MD

Abstract Full Text

JAMA Ophthalmol. 2020;138(1):5-6. doi:10.1001/jamaophthalmol.2019.4782

This Viewpoint discusses the difference between clinical practice settings and the settings of randomized clinical trials in the context of 鈥渞eal-world鈥� treatment and suggests that use of artificial intelligence may ultimately advance physician decision-making in treatment of patients.

Original Investigation

Association Between Polygenic Risk Score and Risk of Myopia

Neema Ghorbani Mojarrad, BSc; Denis Plotnikov, MD; Cathy Williams, MBBS, PhD, FRCOphth; et al.

Abstract Full Text

open access

JAMA Ophthalmol. 2020;138(1):7-13. doi:10.1001/jamaophthalmol.2019.4421

This meta-analysis of 3 genome-wide association studies examines the use of genetic information to predict the risk of myopia development in children in the United Kingdom.

Secondary 12-Month Ocular Outcomes of a Phase 1 Dosing Study of Bevacizumab for Retinopathy of Prematurity

Eric R. Crouch, MD; Raymond T. Kraker, MSPH; David K. Wallace, MD, MPH; et al.

Abstract Full Text

free access

JAMA Ophthalmol. 2020;138(1):14-20. doi:10.1001/jamaophthalmol.2019.4488

This prospective cohort study evaluates ocular outcomes at 12 months鈥� corrected age in infants whose eyes received a dose of 0.625, 0.25, 0.125, 0.063, or 0.031 mg of bevacizumab for type 1 retinopathy of prematurity.

Individual Risk Prediction for Sight-Threatening Retinopathy of Prematurity Using Birth Characteristics

Aldina Pivodic, MSc; Anna-Lena Hård, MD, PhD; Chatarina Löfqvist, PhD; et al.

Abstract Full Text

open access

JAMA Ophthalmol. 2020;138(1):21-29. doi:10.1001/jamaophthalmol.2019.4502

This cohort study creates and validates an easy-to-use prediction model using only birth characteristics and describes a continuous hazard function for retinopathy of prematurity treatment.

Invited Commentary
A Prediction Model for Retinopathy of Prematurity鈥擨s It Ready for Prime Time?
Gui-shuang Ying, PhD

JAMA Ophthalmol

Validation of the Postnatal Growth and Retinopathy of Prematurity Screening Criteria

Gil Binenbaum, MD, MSCE; Lauren A. Tomlinson, BS; Alejandra G. de Alba Campomanes, MD, MPH; et al.

Abstract Full Text

free access has audio

JAMA Ophthalmol. 2020;138(1):31-37. doi:10.1001/jamaophthalmol.2019.4517

This cohort study evaluates the generalizability of the Postnatal Growth and Retinopathy of Prematurity screening criteria in a new cohort of at-risk infants.

Audio Author Interview: Validation of the Postnatal Growth and Retinopathy of Prematurity Screening Criteria

Invited Commentary
Time to Consider Adoption of New Retinopathy of Prematurity Screening Guidelines in the United States
B. Michele Melia, ScM

JAMA Ophthalmol

Economic Value of Anti鈥揤ascular Endothelial Growth Factor Treatment for Patients With Wet Age-Related Macular Degeneration in the United States

Karen Mulligan, PhD; Seth A. Seabury, PhD; Pravin U. Dugel, MD; et al.

Abstract Full Text

free access

JAMA Ophthalmol. 2020;138(1):40-47. doi:10.1001/jamaophthalmol.2019.4557

This economic evaluation study estimates the value generated by anti鈥搗ascular endothelial growth factor treatment for patients with wet age-related macular degeneration and society in the United States.

Invited Commentary
Economic Evaluation of Anti鈥揤ascular Endothelial Growth Factor Therapy for Wet Age-Related Macular Degeneration
Melissa M. Brown, MD, MN, MBA; Gary C. Brown, MD, MBA

JAMA Ophthalmol

Risk of Death Associated With Intravitreal Anti鈥揤ascular Endothelial Growth Factor Therapy: A Systematic Review and Meta-analysis

Michele Reibaldi, MD, PhD; Matteo Fallico, MD; Teresio Avitabile, MD; et al.

Abstract Full Text

free access

JAMA Ophthalmol. 2020;138(1):50-57. doi:10.1001/jamaophthalmol.2019.4636

This meta-analysis assesses whether intravitreal anti鈥搗ascular endothelial growth factor therapy and which variables might be associated with increased risk of mortality among patients with retinal disease.

Characteristics and Risk Factors Associated With Diagnosed and Undiagnosed Symptomatic Dry Eye Using a Smartphone Application

Takenori Inomata, MD, PhD, MBA; Masao Iwagami, MD, PhD, MSc, MPH; Masahiro Nakamura, MD, PhD; et al.

Abstract Full Text

free access

JAMA Ophthalmol. 2020;138(1):58-68. doi:10.1001/jamaophthalmol.2019.4815

This cross-sectional study evaluates the incidence of symptomatic vs no symptomatic and diagnosed vs undiagnosed dry eye disease throughout Japan.

Invited Commentary
Epidemiologic Research in Dry Eye Disease and the Utility of Mobile Health Technology
Michael T. M. Wang, MBChB; William K. Diprose, MBChB; Jennifer P. Craig, PhD FCOptom

JAMA Ophthalmol

Brief Report

Incidence and Management of Glaucoma or Glaucoma Suspect in the First Year After Pediatric Lensectomy

Sharon F. Freedman, MD; Raymond T. Kraker, MSPH; Michael X. Repka, MD, MBA; et al.

Abstract Full Text

JAMA Ophthalmol. 2020;138(1):71-75. doi:10.1001/jamaophthalmol.2019.4571

This cohort study estimates the incidence of postoperative glaucoma and glaucoma suspect among patients who underwent cataract surgery before age 13 years and evaluates potential risk factors.

Association of Limiting Opioid Prescriptions With Use of Opioids After Corneal Surgery

Maria A. Woodward, MD, MSc; Yibing Zhang, BA; Bradford Tannen, MD, JD; et al.

Abstract Full Text

JAMA Ophthalmol. 2020;138(1):76-80. doi:10.1001/jamaophthalmol.2019.4432

This cohort study assesses the association of decreased prescription of opioids with the quantity of postsurgical use of opioids among adults undergoing corneal surgery.

Differentiating Retinal Detachment and Retinoschisis Using Handheld Optical Coherence Tomography in Stage 4 Retinopathy of Prematurity

Xi Chen, MD, PhD; S. Grace Prakalapakorn, MD, MPH; Sharon F. Freedman, MD; et al.

Abstract Full Text

JAMA Ophthalmol. 2020;138(1):81-85. doi:10.1001/jamaophthalmol.2019.4796

This study compares features of eyes with stage 4 retinopathy of prematurity (ROP) using optical coherence tomography (OCT) vs indirect ophthalmoscopy findings and grading of photographs.

Invited Commentary

A Prediction Model for Retinopathy of Prematurity鈥擨s It Ready for Prime Time?

Gui-shuang Ying, PhD

Abstract Full Text

JAMA Ophthalmol. 2020;138(1):29-30. doi:10.1001/jamaophthalmol.2019.4608

Time to Consider Adoption of New Retinopathy of Prematurity Screening Guidelines in the United States

B. Michele Melia, ScM

Abstract Full Text

JAMA Ophthalmol. 2020;138(1):38-39. doi:10.1001/jamaophthalmol.2019.4622

Economic Evaluation of Anti鈥揤ascular Endothelial Growth Factor Therapy for Wet Age-Related Macular Degeneration

Melissa M. Brown, MD, MN, MBA; Gary C. Brown, MD, MBA

Abstract Full Text

JAMA Ophthalmol. 2020;138(1):48-49. doi:10.1001/jamaophthalmol.2019.4582

Epidemiologic Research in Dry Eye Disease and the Utility of Mobile Health Technology

Michael T. M. Wang, MBChB; William K. Diprose, MBChB; Jennifer P. Craig, PhD FCOptom

Abstract Full Text

JAMA Ophthalmol. 2020;138(1):69-70. doi:10.1001/jamaophthalmol.2019.4833

Special Communication

Assessing the Use of Incorrectly Scaled Optical Coherence Tomography Angiography Images in Peer-Reviewed Studies: A Systematic Review

Samantha Llanas, BS; Rachel E. Linderman, BA; Fred K. Chen, MBBS, PhD, FRANZCO; et al.

Abstract Full Text

JAMA Ophthalmol. 2020;138(1):86-94. doi:10.1001/jamaophthalmol.2019.4821

This systematic review assesses the percentage of ophthalmology studies using optical coherence tomography angiography images that include correct scaling to make such images comprehensible to readers.

JAMA Ophthalmology Clinical Challenge

Relapsing Optic Neuropathy and Multiple Cranial Neuropathies in a Middle-aged Woman

Konstantinos A. A. Douglas, MD, DVM, MBA; Vivian Paraskevi Douglas, MD, DVM, MBA; Dean M. Cestari, MD

Abstract Full Text

JAMA Ophthalmol. 2020;138(1):95-96. doi:10.1001/jamaophthalmol.2019.4410

A 55-year-old woman presents with decreased visual acuity, and magnetic resonance imaging shows thickening of the optic nerves and other areas of the brain. Over 5 years, she returns with multiple similar presentations. What would you do next?

Chronic Conjunctivitis in an Older Patient With Ptosis

Josiah To, MASc; Marian Macsai, MD; Paul O. Phelps, MD

Abstract Full Text

JAMA Ophthalmol. 2020;138(1):97-98. doi:10.1001/jamaophthalmol.2019.4439

An older woman presents with chronic pain in her left eye that has recurred after several courses of treatment. What would you do next?

A Black-Pigmented Eyelid Nodule in an African American Woman

Nina S. Boal, MD; Tatyana Milman, MD; Carol L. Shields, MD

Abstract Full Text

JAMA Ophthalmol. 2020;138(1):99-100. doi:10.1001/jamaophthalmol.2019.4591

An African American woman presents with a pigmented lesion on her upper eyelid with madarosis, eyelid margin notching, and telangiectasia. What would you do next?

Research Letter

A Geometric Analysis of Eye Dominance Suggesting That Rembrandt and Leonardo da Vinci Had Straight Eyes After All

Ahmed F. Shakarchi, MBChB, MPH; David L. Guyton, MD

Abstract Full Text

free access

JAMA Ophthalmol. 2020;138(1):101-102. doi:10.1001/jamaophthalmol.2019.4603

This study theorizes about the straightness of the eyes of Rembrandt Harmenszoon van Rijn and Leonardo da Vinci through diagrams and images.

Observation

SETD2 Mutation in an Aggressive Optic Nerve Glioma

Ashley A. Campbell, MD; Robyn D. Gartrell-Corrado, MD; Mahesh Mansukhani, MD; et al.

Abstract Full Text

JAMA Ophthalmol. 2020;138(1):102-104. doi:10.1001/jamaophthalmol.2019.4511

This case report describes a 19-month-old boy with a SETD2 mutation in an aggressive optic nerve glioma.

Ophthalmic Images

Corneal Allograft Treatment for Conjunctival Erosion Caused by Electronic Retinal Implant

Felix Rommel, MD; Salvatore Grisanti, MD

Abstract Full Text

online only

JAMA Ophthalmol. 2020;138(1):e190051. doi:10.1001/jamaophthalmol.2019.0051

This case report describes a full-thickness cornea graft treatment for recurrent conjunctival dehiscence after Argus II implant to avoid explant.

Self-inflicted Ocular Injury鈥擠oes It Relieve the Pain?

Naresh Babu, MS; Piyush Kohli, MS; Jayant Kumar, MS

Abstract Full Text

online only

JAMA Ophthalmol. 2020;138(1):e190055. doi:10.1001/jamaophthalmol.2019.0055

This case report describes a color photograph showing the insulin needle inside the eye with its extrascleral posterior edge and a volume-rendered multiplanar reconstruction image showing multiple needles in the orbit.