January 1, 2022 Issue of JAMA Ophthalmology

January 2022, Vol 140, No. 1, Pages 10-100

Original Investigation

Nicotinamide and Pyruvate for Neuroenhancement in Open-Angle Glaucoma: A Phase 2 Randomized Clinical Trial

Carlos Gustavo De Moraes, MD, MPH, PhD; Simon W. M. John, PhD; Pete A. Williams, PhD; et al.

Abstract Full Text

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JAMA Ophthalmol. 2022;140(1):11-18. doi:10.1001/jamaophthalmol.2021.4576

This phase 2 randomized clinical trial tests the hypothesis that a combination of nicotinamide and pyruvate can improve retinal ganglion cell function in individuals with glaucoma as measured with standard automated perimetry.

Invited Commentary
Neuroprotective Therapies for Patients With Worsening Glaucoma Despite Adequate Intraocular Pressure Lowering鈥擲hort-term Neurorecovery, Long-term Neuroprotection?
Pradeep Y. Ramulu, MD, MHS, PhD

JAMA Ophthalmol

Safety Outcomes of Brolucizumab in Neovascular Age-Related Macular Degeneration: Results From the IRIS Registry and Komodo Healthcare Map

Arshad M. Khanani, MD, MA; Marco A. Zarbin, MD, PhD; Mark R. Barakat, MD; et al.

Abstract Full Text

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JAMA Ophthalmol. 2022;140(1):20-28. doi:10.1001/jamaophthalmol.2021.4585

This cohort study assesses the real-world incidence of intraocular inflammation, including retinal vasculitis and/or retinal vascular occlusion for patients with neovascular age-related macular degeneration who underwent brolucizumab treatment.

Invited Commentary
Risk Factors for Intraocular Inflammation After Brolucizumab Treatment
Caroline R. Baumal, MD

JAMA Ophthalmol

Defining High-risk Retinoblastoma: A Multicenter Global Survey

Swathi Kaliki, MD; Carol L. Shields, MD; Nathalie Cassoux, MD, PhD; et al.

Abstract Full Text

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JAMA Ophthalmol. 2022;140(1):30-36. doi:10.1001/jamaophthalmol.2021.4732

This survey study evaluates variations in the definition of high-risk histopathologic features for metastasis of retinoblastoma in different ocular oncology practices around the world.

Association Between Pentosan Polysulfate Sodium and Retinal Disorders

Gerald McGwin Jr, MS, PhD; Paul MacLennan, MPH, PhD; Cynthia Owsley, PhD, MSPH

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JAMA Ophthalmol. 2022;140(1):37-42. doi:10.1001/jamaophthalmol.2021.4778

This analysis of disproportionality used adverse event reports to assess the association of pentosan polysulfate sodium exposure and maculopathy.

Association of Public Health Measures During the COVID-19 Pandemic With the Incidence of Infectious Conjunctivitis

Juan M. Lavista Ferres, MSC; Thomas Meirick, MD; Whitney Lomazow, MD; et al.

Abstract Full Text

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JAMA Ophthalmol. 2022;140(1):43-49. doi:10.1001/jamaophthalmol.2021.4852

This comparative effectiveness study evaluates whether internet search interest and emergency department visits for infectious conjunctivitis were associated with public health interventions adopted during the COVID-19 pandemic.

Invited Commentary
Using the Internet to Detect Emerging Outbreaks鈥擜rmchair Epidemiology
Alfred Sommer, MD, MHS

JAMA Ophthalmol

Ocular Sequelae in a Population-Based Cohort of Youth Diagnosed With Diabetes During a 50-Year Period

Patricia Bai, BA; Andrew J. Barkmeier, MD; David O. Hodge, MS; et al.

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JAMA Ophthalmol. 2022;140(1):51-57. doi:10.1001/jamaophthalmol.2021.5052

This cohort study describes the risk of developing diabetes-associated ocular complications among children diagnosed with type 1 or type 2 diabetes during a 50-year period.

Invited Commentary
The Growing Need to Understand Diabetic Retinopathy Outcomes in Youth
Jennifer K. Sun, MD, MPH

JAMA Ophthalmol

Effect of Nightly Lower Body Negative Pressure on Choroid Engorgement in a Model of Spaceflight-Associated Neuro-ocular Syndrome: A Randomized Crossover Trial

Christopher M. Hearon Jr, PhD; Katrin A. Dias, PhD; Gautam Babu, MD; et al.

Abstract Full Text

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JAMA Ophthalmol. 2022;140(1):59-65. doi:10.1001/jamaophthalmol.2021.5200

This randomized crossover trial tests the hemodynamic stability and efficacy of a specialized sleeping sack capable of delivering nightly lower body negative pressure.

Cumulative Mortality and Factors Associated With Outcomes of Mucormycosis After COVID-19 at a Multispecialty Tertiary Care Center in India

Twinkle Choksi, MD; Anamika Agrawal, DNB; Purva Date, DNB; et al.

Abstract Full Text

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JAMA Ophthalmol. 2022;140(1):66-72. doi:10.1001/jamaophthalmol.2021.5201

This case-control study reports outcomes and cumulative mortality rates among patients with COVID-19鈥揳ssociated rhino-orbitocerebral mucormycosis.

Invited Commentary
Rhino-Orbital-Cerebral Mucormycosis鈥擜nother Deadly Complication of COVID-19 Infection
Andrea A. Tooley, MD; Elizabeth A. Bradley, MD, MHS; John J. Woog, MD

JAMA Ophthalmol

Brief Report

Auditory Reminder Cues to Promote Proactive Scanning on Approach to Intersections in Drivers With Homonymous Hemianopia: Driving With Hemianopia, IX

Jing Xu, PhD; Birte Emmermann, MSc; Alex R. Bowers, PhD

Abstract Full Text

JAMA Ophthalmol. 2022;140(1):75-78. doi:10.1001/jamaophthalmol.2021.5007

This cross-sectional study of a driving simulation evaluates whether auditory reminder cues promoted proactive scanning on approach to intersections in individuals with homonymous hemianopia.

Incidence of Accommodations for Patients With Significant Vision Limitations in Physicians鈥� Offices in the US

Lisa I. Iezzoni, MD, MSc; Sowmya R. Rao, PhD; Julie Ressalam, MPH; et al.

Abstract Full Text

JAMA Ophthalmol. 2022;140(1):79-84. doi:10.1001/jamaophthalmol.2021.5072

This US physician survey study explores the extent of basic accommodations physicians practicing in the US provide to patients with significant vision limitations in outpatient care.

Invited Commentary
Improving Health Care Accessibility for People With Vision Impairment鈥擜 Call to Account
Jacqueline Ramke, MPH, PhD; Brandon A. M. Ah Tong, BSocSci; Bonnielin K. Swenor, PhD

JAMA Ophthalmol

Invited Commentary

Neuroprotective Therapies for Patients With Worsening Glaucoma Despite Adequate Intraocular Pressure Lowering鈥擲hort-term Neurorecovery, Long-term Neuroprotection?

Pradeep Y. Ramulu, MD, MHS, PhD

Abstract Full Text

JAMA Ophthalmol. 2022;140(1):18-19. doi:10.1001/jamaophthalmol.2021.4573

Risk Factors for Intraocular Inflammation After Brolucizumab Treatment

Caroline R. Baumal, MD

Abstract Full Text

JAMA Ophthalmol. 2022;140(1):28-29. doi:10.1001/jamaophthalmol.2021.4586

Using the Internet to Detect Emerging Outbreaks鈥擜rmchair Epidemiology

Alfred Sommer, MD, MHS

Abstract Full Text

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JAMA Ophthalmol. 2022;140(1):50. doi:10.1001/jamaophthalmol.2021.4853

The Growing Need to Understand Diabetic Retinopathy Outcomes in Youth

Jennifer K. Sun, MD, MPH

Abstract Full Text

JAMA Ophthalmol. 2022;140(1):57-58. doi:10.1001/jamaophthalmol.2021.5050

Rhino-Orbital-Cerebral Mucormycosis鈥擜nother Deadly Complication of COVID-19 Infection

Andrea A. Tooley, MD; Elizabeth A. Bradley, MD, MHS; John J. Woog, MD

Abstract Full Text

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JAMA Ophthalmol. 2022;140(1):73-74. doi:10.1001/jamaophthalmol.2021.5202

Improving Health Care Accessibility for People With Vision Impairment鈥擜 Call to Account

Jacqueline Ramke, MPH, PhD; Brandon A. M. Ah Tong, BSocSci; Bonnielin K. Swenor, PhD

Abstract Full Text

JAMA Ophthalmol. 2022;140(1):84-85. doi:10.1001/jamaophthalmol.2021.5069

JAMA Ophthalmology Clinical Challenge

Periorbital Mass in a 44-Year-Old Woman

Diana H. Kim, MD; Vivian Lee, MD; César A. Briceño, MD

Abstract Full Text

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JAMA Ophthalmol. 2022;140(1):86-87. doi:10.1001/jamaophthalmol.2021.1441

This case report describes a 44-year-old woman with a mass on the lateral canthus of her right eye that had grown over 2 months and was tender to palpation. What would you do next?

An Atypical Case of Optic Neuropathy

Katherine J. Williams, MD; Richard C. Allen, MD, PhD

Abstract Full Text

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JAMA Ophthalmol. 2022;140(1):88-89. doi:10.1001/jamaophthalmol.2021.1466

A 17-year-old girl presented with 3 months of decreased vision in the right eye associated with throbbing pain with eye movement. Magnetic resonance imaging revealed a fusiform expansion of the right optic nerve and enhancement of the orbital, canalicular, and prechiasmatic segments of the right optic nerve. What would you do next?

Blurry Vision in a Patient With Leukemia

Danny A. Mammo, MD; Aleksandra R. Rachitskaya, MD; Arun D. Singh, MD

Abstract Full Text

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JAMA Ophthalmol. 2022;140(1):90-91. doi:10.1001/jamaophthalmol.2021.1456

A patient with chronic myelogenous leukemia presented with blurry vision and peripapillary intraretinal and preretinal hemorrhages obscuring the optic disc margins of both eyes. What would you do next?

Homonymous Hemianopia With Normal Neuroimaging

Jingyi Ma, BMSc; Andrew Micieli, MD, MMI; Jonathan A. Micieli, MD, CM

Abstract Full Text

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JAMA Ophthalmol. 2022;140(1):92-93. doi:10.1001/jamaophthalmol.2021.3356

A 46-year-old man presented with a 2-week history of a persistent blurred area in his right lower visual field of both eyes and colors surrounding the dark area that lasted 2 to 3 minutes at a time and occurred multiple times per day. His medical history was significant for dyslipidemia and he also reported feeling lethargic, with polydipsia and a dull mild holocephalic headache. What would you do next?

Research Letter

Prevalence of Psychoactive Substance Use Among Middle-aged and Older Adults With Visual Impairment in the US

Benjamin H. Han, MD; Jason F. Leddy, BS; Francisco A. Lopez; et al.

Abstract Full Text

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JAMA Ophthalmol. 2022;140(1):94-95. doi:10.1001/jamaophthalmol.2021.4667

This cross-sectional study estimates the prevalence of psychoactive substance use among middle-aged and older adults with visual impairment in the US.

Ophthalmic Images

A Pigmented Vitreous Cyst Within the Posterior Precortical Vitreous Pocket

Xiaohong Guo, MD; Bo Lei, MD, PhD; Yongfeng Gao, MD, PhD

Abstract Full Text

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JAMA Ophthalmol. 2022;140(1):e214681. doi:10.1001/jamaophthalmol.2021.4681

This case report describes a 48-year-old woman with a ball-like floating cyst near the macula with limited movement when the eyes moved.

Video: Pigmented Vitreous Cyst Within the Posterior Precortical Vitreous Pocket

Spoke-Wheel鈥揝haped Deposits Over Intraocular Lens

Mayank Jain, MD; Ramesh Kekunnaya, MD

Abstract Full Text

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JAMA Ophthalmol. 2022;140(1):e214687. doi:10.1001/jamaophthalmol.2021.4687

This case report describes a 13-year-old girl with a history of penetrating trauma who developed multiple spokelike deposits over the anterior and posterior surface of an intraocular lens.