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April 25, 2024
Original Investigation

Postoperative Hypofractionated Intensity-Modulated Radiotherapy With Concurrent Chemotherapy in Cervical Cancer: The POHIM-CCRT Nonrandomized Controlled Trial

Abstract Full Text
JAMA Oncol. Published online April 25, 2024. doi:10.1001/jamaoncol.2024.0565

This nonrandomized controlled trial investigates the acute toxic effects of treatment with hypofractionated pelvic intensity-modulated radiotherapy and concurrent chemotherapy among women who experienced lymph node metastasis, parametrial invasion, or positive resection margins after radical hysterectomy for treatment of confirmed cervical cancer.

Brief Report

Omission of Axillary Dissection Following Nodal Downstaging With Neoadjuvant Chemotherapy

Abstract Full Text
JAMA Oncol. Published online April 25, 2024. doi:10.1001/jamaoncol.2024.0578

This cohort study examines oncological outcomes after sentinel lymph node biopsy with dual-tracer mapping or targeted axillary dissection.

Research Letter

Gefitinib vs Gefitinib Plus Pemetrexed and Carboplatin Chemotherapy in EGFR-Variant Lung Cancer—Long-Term Results of a Randomized Clinical Trial

Abstract Full Text
JAMA Oncol. Published online April 25, 2024. doi:10.1001/jamaoncol.2024.0584

This randomized clinical trial examines whether adding chemotherapy with pemetrexed and carboplatin to gefitinib improves survival among patients with epidermal growth factor receptor (EGFR)–variant non–small cell lung cancer.

Invited Commentary

Interpreting the Findings of the POHIM-CCRT Trial

Abstract Full Text
JAMA Oncol. Published online April 25, 2024. doi:10.1001/jamaoncol.2024.0048
Cancer Care Chronicles

Lessons in Truth-Telling From the Novels of Thomas Wolfe

Abstract Full Text
JAMA Oncol. Published online April 25, 2024. doi:10.1001/jamaoncol.2024.0597

This essay describes the author’s experience with learning about building trust with every patient and family interaction through literature.

Comment & Response

Clarification Regarding Breast Cancer Stage in France

Abstract Full Text
JAMA Oncol. Published online April 25, 2024. doi:10.1001/jamaoncol.2024.0668

Clarification Regarding Breast Cancer Stage in France—Reply

Abstract Full Text
JAMA Oncol. Published online April 25, 2024. doi:10.1001/jamaoncol.2024.0671
April 18, 2024
Original Investigation

Development and Validation of an 18-Gene Urine Test for High-Grade Prostate Cancer

Abstract Full Text
open access
JAMA Oncol. Published online April 18, 2024. doi:10.1001/jamaoncol.2024.0455

This report describes the development of an 18-gene urine panel for high-grade prostate cancer and validates its external performance relative to current guideline-endorsed biomarkers.

Brief Report

Adherence to American Cancer Society Nutrition and Physical Activity Guidelines Among Cancer Survivors

Abstract Full Text
JAMA Oncol. Published online April 18, 2024. doi:10.1001/jamaoncol.2024.0470

This cross-sectional study uses data from the Behavioral Risk Factor Surveillance System to evaluate adherence to the American Cancer Society (ACS) nutrition and physical activity guidelines among cancer survivors.

Research Letter

Allogeneic CD19/CD22 CAR T-Cell Therapy for B-Cell Acute Lymphoblastic Leukemia

Abstract Full Text
open access
JAMA Oncol. Published online April 18, 2024. doi:10.1001/jamaoncol.2024.0473

This case series reports durable remissions in 2 patients with relapsed/refractory B-cell acute lymphoblastic leukemia treated with allogeneic bispecific CD19/CD22-targeting chimeric antigen receptor T cells.

T-Cell Malignant Neoplasms After Chimeric Antigen Receptor T-Cell Therapy

Abstract Full Text
has audio
JAMA Oncol. Published online April 18, 2024. doi:10.1001/jamaoncol.2024.0662

This cohort study assesses the increase in second primary malignant neoplasms and T-cell malignant neoplasm cases associated with chimeric antigen receptor–T cells.

Viewpoint

Policy Priorities in Cancer Care for Transgender People

Abstract Full Text
JAMA Oncol. Published online April 18, 2024. doi:10.1001/jamaoncol.2024.0451

This Viewpoint calls for health care systems, oncologists, and staff to prioritize and adopt policies that are inclusive and respectful of transgender patients with cancer.

Poetry and Oncology

The Metastatic Waltz

Abstract Full Text
JAMA Oncol. Published online April 18, 2024. doi:10.1001/jamaoncol.2024.0314
Correction

Error in Figure

Abstract Full Text
free access
JAMA Oncol. Published online April 18, 2024. doi:10.1001/jamaoncol.2024.1062
April 11, 2024
Original Investigation

Second Primary Breast Cancer in Young Breast Cancer Survivors

Abstract Full Text
JAMA Oncol. Published online April 11, 2024. doi:10.1001/jamaoncol.2024.0286

This cohort study examines the risk of a second primary breast cancer in women who were aged 40 years or younger when first diagnosed with breast cancer.

Brief Report

Patient-Reported Outcomes as a Recruitment Strategy for Clinical Trial Enrollment

Abstract Full Text
JAMA Oncol. Published online April 11, 2024. doi:10.1001/jamaoncol.2024.0280

This study examines the association between electronic patient-reported outcome–prompted recruitment strategies and clinical trial enrollment.

Special Communication

American Radium Society Appropriate Use Criteria for Unresectable Locally Advanced Non–Small Cell Lung Cancer

Abstract Full Text
has active quiz
JAMA Oncol. Published online April 11, 2024. doi:10.1001/jamaoncol.2024.0294

This Special Communication discusses case-referenced consensus and evidence-based guidelines to inform clinical practice in unresectable locally advanced non–small cell lung cancer (NSCLC).

Viewpoint

Using Nerve Blocks for Addressing Radiation-Induced Pain During Pelvic Cancer Treatment

Abstract Full Text
JAMA Oncol. Published online April 11, 2024. doi:10.1001/jamaoncol.2024.0304

This Viewpoint discusses the use of nerve blocks for pain during pelvic cancer treatment.

Comment & Response

Local Immunoradiotherapy in Patients With Metastatic Soft-Tissue Sarcoma

Abstract Full Text
JAMA Oncol. Published online April 11, 2024. doi:10.1001/jamaoncol.2024.0308

Local Immunoradiotherapy in Patients With Metastatic Soft-Tissue Sarcoma—Reply

Abstract Full Text
JAMA Oncol. Published online April 11, 2024. doi:10.1001/jamaoncol.2024.0311
April 5, 2024
Original Investigation

Magnetic Resonance Imaging in Prostate Cancer Screening: A Systematic Review and Meta-Analysis

Abstract Full Text
JAMA Oncol. Published online April 5, 2024. doi:10.1001/jamaoncol.2024.0734

This systematic review and meta-analysis examines evidence regarding screening pathways incorporating magnetic resonance imaging with targeted biopsy and assess their diagnostic value compared with prostate-specific antigen–based screening with systematic biopsy strategies.

April 4, 2024
Original Investigation

FOLFIRI Plus Durvalumab With or Without Tremelimumab in Second-Line Treatment of Advanced Gastric or Gastroesophageal Junction Adenocarcinoma: The PRODIGE 59-FFCD 1707-DURIGAST Randomized Clinical Trial

Abstract Full Text
open access
JAMA Oncol. Published online April 4, 2024. doi:10.1001/jamaoncol.2024.0207

This randomized clinical trial examines the efficacy of 1 or 2 immune checkpoint inhibitors combined with FOLFIRI in the treatment of advanced gastric/GEJ adenocarcinoma.

Clinical Value of Molecular Targets and FDA-Approved Genome-Targeted Cancer Therapies

Abstract Full Text
JAMA Oncol. Published online April 4, 2024. doi:10.1001/jamaoncol.2024.0194

This cohort study assesses the validity of molecular targets and therapeutic benefits of US Food and Drug Administration (FDA)–approved genome-targeted cancer drugs based on the outcomes of their corresponding pivotal clinical trials.

Viewpoint

Ovarian Cancer Isn’t Just a White Woman’s Disease

Abstract Full Text
JAMA Oncol. Published online April 4, 2024. doi:10.1001/jamaoncol.2024.0191

This Viewpoint highlights the need for recognition that ovarian cancer affects women from racial and ethnic minority groups worldwide and that the rates of ovarian cancer are increasing in those populations while decreasing among White women.

Editorial

Immunotherapy in Gastric Cancer—Choosing Methods or Results

Abstract Full Text
JAMA Oncol. Published online April 4, 2024. doi:10.1001/jamaoncol.2023.7262
Comment & Response

Locally Advanced Relapse May Not Be Equal to Stage 3 Non–Small Cell Lung Cancer

Abstract Full Text
JAMA Oncol. Published online April 4, 2024. doi:10.1001/jamaoncol.2024.0231

Locally Advanced Relapse May Not Be Equal to Stage 3 Non–Small Cell Lung Cancer—Reply

Abstract Full Text
JAMA Oncol. Published online April 4, 2024. doi:10.1001/jamaoncol.2024.0234
Correction

Error in Author Degree

Abstract Full Text
free access
JAMA Oncol. Published online April 4, 2024. doi:10.1001/jamaoncol.2024.0742
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