March 5, 2024 Issue of JAMA

March 5, 2024, Vol 331, No. 9, Pages 721-808

In This Issue of JAMA

Audio Highlights

Abstract Full Text

free access online only has audio

JAMA. 2024;331(9):e2318219. doi:10.1001/jama.2023.18219

Audio: RNAi With Zilebesiran for Hypertension, Timing of IV Thrombolysis Before Thrombectomy for Stroke, Cardiac Amyloidosis Review, and more

Original Investigation

RNA Interference With Zilebesiran for Mild to Moderate Hypertension: The KARDIA-1 Randomized Clinical Trial

George L. Bakris, MD; Manish Saxena, MBBS; Anil Gupta, MD; et al.

Abstract Full Text

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JAMA. 2024;331(9):740-749. doi:10.1001/jama.2024.0728

This phase 2 randomized trial examines the antihypertensive efficacy and safety of different zilebesiran dosing regimens.

Editorial
RNA Injection Every 6 Months to Improve Adherence and Lower Blood Pressure in Patients With Hypertension
Ernesto L. Schiffrin, MD, PhD

JAMA

Endovascular Thrombectomy for Large Ischemic Stroke Across Ischemic Injury and Penumbra Profiles

Amrou Sarraj, MD; Ameer E. Hassan, DO; Michael G. Abraham, MD; et al.

Abstract Full Text

JAMA. 2024;331(9):750-763. doi:10.1001/jama.2024.0572

This exploratory analysis of the SELECT2 trial assesses the relationship between imaging estimates of irreversibly injured brain (core) and at-risk regions (mismatch) and the association of mismatch with clinical outcomes and endovascular treatment effect in adult patients with acute ischemic stroke due to occlusion of the internal carotid or middle cerebral artery and large ischemic core in 31 global centers between October 2019 and September 2022.

Editorial
Thrombectomy in Medium to Large Ischemic Core: Do Patients Still Need to Be SELECTed?
Umberto Pensato, MD; Ronda Lun, MD; Andrew Demchuk, MD

JAMA
Advances in Thrombectomy for Acute Ischemic Stroke
Colin Derdeyn, MD

JAMA Surg

Time to Treatment With Intravenous Thrombolysis Before Thrombectomy and Functional Outcomes in Acute Ischemic Stroke: A Meta-Analysis

Johannes Kaesmacher, MD, PhD; Fabiano Cavalcante, MD; Manon Kappelhof, MD, PhD; et al.

Abstract Full Text

JAMA. 2024;331(9):764-777. doi:10.1001/jama.2024.0589

This individual participant data meta-analysis assesses treatment time from stroke symptom onset and disability level after treatment with intravenous thrombolysis plus thrombectomy vs thrombectomy alone among patients who presented directly at thrombectomy-capable stroke centers.

Editorial
Advances in Thrombectomy for Acute Ischemic Stroke
Colin Derdeyn, MD

JAMA Surg

Research Letter

Delivery Device Patents on GLP-1 Receptor Agonists

Rasha Alhiary, PharmD, MS; Sarah Gabriele, LLM, MBE; Aaron S. Kesselheim, MD, JD, MPH; et al.

Abstract Full Text

JAMA. 2024;331(9):794-796. doi:10.1001/jama.2024.0919

This study analyzed the US Food and Drug Administration鈥搇isted patents on glucagon-like peptide 1 (GLP-1) receptor agonists to determine their claim characteristics and the potential barriers they pose to generic entry.

Trends in Phenylephrine and Pseudoephedrine Sales in the US

Timothy S. Anderson, MD, MAS; Katie J. Suda, PharmD, MS; Walid F. Gellad, MD, MPH; et al.

Abstract Full Text

JAMA. 2024;331(9):796-798. doi:10.1001/jama.2023.27932

This study examines purchasing patterns regarding oral decongestants, concerns about their efficacy, and the need for timelier postmarket evaluation.

Viewpoint

Maintenance of Certification鈥擳he Value to Patients and Physicians

Robert O. Roswell, MD; Erica N. Johnson, MD; Rajeev Jain, MD

Abstract Full Text

JAMA. 2024;331(9):727-728. doi:10.1001/jama.2024.0374

This Viewpoint discusses the ABIM鈥檚 continuing efforts to innovate and streamline maintenance of certification, including the recently launched Longitudinal Knowledge Assessment (LKA), to better accommodate physicians鈥� schedules and desires for flexibility.

Out of Touch

Salvatore Mangione, MD; Maria Basile, MD, MBA; Stephen G. Post, PhD

Abstract Full Text

JAMA. 2024;331(9):729-730. doi:10.1001/jama.2024.0888

This Viewpoint discusses the role of touch in medical tradition and its importance in medicine today.

A Piece of My Mind

I Am Your Father

Daniel A. Gorman, MD

Abstract Full Text

JAMA. 2024;331(9):731-732. doi:10.1001/jama.2024.0437

In this narrative medicine essay, a child psychiatrist is left with no choice but to sit with his 6-year-old son after all his child-behavior strategies failed to jolt the child out of his meltdown, sparked by a long line for a Star Wars ride at a Disney park.

Editorial

RNA Injection Every 6 Months to Improve Adherence and Lower Blood Pressure in Patients With Hypertension

Ernesto L. Schiffrin, MD, PhD

Abstract Full Text

JAMA. 2024;331(9):733-735. doi:10.1001/jama.2023.26071

Thrombectomy in Medium to Large Ischemic Core: Do Patients Still Need to Be SELECTed?

Umberto Pensato, MD; Ronda Lun, MD; Andrew Demchuk, MD

Abstract Full Text

JAMA. 2024;331(9):736-738. doi:10.1001/jama.2023.27154

Communicating Medicine

Communicating Medicine鈥擜 New JAMA Series

Anne R. Cappola, MD, ScM; Kirsten Bibbins-Domingo, PhD, MD, MAS

Abstract Full Text

free access

JAMA. 2024;331(9):739. doi:10.1001/jama.2023.15086

Review

Cardiac Amyloidosis Due to Transthyretin Protein: A Review

Frederick L. Ruberg, MD; Mathew S. Maurer, MD

Abstract Full Text

has active quiz has audio

JAMA. 2024;331(9):778-791. doi:10.1001/jama.2024.0442

This Review summarizes the clinical presentation, diagnosis, and treatment of amyloidosis from transthyretin (ATTR) protein cardiomyopathy.

Audio: Heart Failure Due to Transthyretin Protein Amyloidosis
Audio: Cardiac Amyloidosis and the V142I Transthyretin Variant

Editorial
Heart Failure in African American Individuals, Version 2.0
Clyde W. Yancy, MD, MSc

JAMA
- Audio: Cardiac Amyloidosis and the V142I Transthyretin Variant
Addressing Health Disparities鈥擳he Case for Variant Transthyretin Cardiac Amyloidosis Grows Stronger
Mathew S. Maurer, MD; Edward J. Miller, MD, PhD; Frederick L. Ruberg, MD

JAMA
- Audio: Cardiac Amyloidosis and the V142I Transthyretin Variant

JAMA Insights

Communicating Medicine

Delivering Effective Messages in the Patient-Clinician Encounter

Joseph N. Cappella, PhD; Richard L. Street Jr, PhD

Abstract Full Text

has active quiz has audio

JAMA. 2024;331(9):792-793. doi:10.1001/jama.2024.0371

This JAMA Insights discusses the importance of effective patient-clinician communication and provides strategies for clinicians that can enhance accurate information gathering and exchange, encourage patient engagement, enhance comprehension, and ensure retention of the information.